{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T20:17:04Z","timestamp":1760300224563,"version":"3.37.3"},"reference-count":37,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT Gamma Knife\u00ae radiosurgery (GKRS) for trigeminal neuralgia is an effective treatment with at least a 50% reduction of pain in 75-95% of patients.  Objective: To present the first series of patients treated for trigeminal neuralgia using GKRS in Latin America.  Methods: Retrospective analysis. Analysis consisted of time to improvement of symptoms, best Barrow Neurological Institute scale (BNI) score after procedure, time without pain, time to recurrence and post-procedural hypoesthesia.  Results: Nineteen cases of classical trigeminal neuralgia were analyzed and three cases of symptomatic trigeminal neuralgia were described. Mean time from symptom onset to radiosurgery was 99.6 months, and 78.9% of patients had undergone invasive procedures before treatment. Patients were followed for a mean of 21.7 months. BNI I was achieved in 36.8%, IIIa in 21.1%, IIIb in 21.1%, IV in 5.3% and V in 15.7%. New hypoesthesia developed in 12.1% patients, which was associated with achieving BNI I after the procedure (p &lt; 0.05). Time from diagnosis to GKRS was higher in patients who failed to achieve BNI I (143 vs. 76 months). The distance from the root entry zone in patients who achieved BNI I was greater than patients who did not (1.94 vs. 1.14 mm). Mean distance from the root entry zone in patients with new hypoesthesia was 2.85 mm vs. 1.06 mm (p = 0.06).  Conclusion: Clinical response to GKRS is related to the time between diagnosis and procedure, thus its indication should be considered early in the management of these patients.<\/jats:p>","DOI":"10.1590\/0004-282x20190027","type":"journal-article","created":{"date-parts":[[2019,5,11]],"date-time":"2019-05-11T15:31:09Z","timestamp":1557588669000},"page":"232-238","source":"Crossref","is-referenced-by-count":7,"title":["Gamma knife radiosurgery for trigeminal neuralgia: first case series from Latin America"],"prefix":"10.1590","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6736-7195","authenticated-orcid":false,"given":"Felipe","family":"Constanzo","sequence":"first","affiliation":[{"name":"Instituto de Neurologia de Curitiba,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodrigo Souza da","family":"Silva","sequence":"additional","affiliation":[{"name":"Instituto de Neurologia de Curitiba,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel Benzecry","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Instituto de Neurologia de Curitiba,  Brasil; Instituto de Neurologia de Curitiba,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Alice","family":"Ferragut","sequence":"additional","affiliation":[{"name":"Instituto de Neurologia de Curitiba,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Coelho Neto","sequence":"additional","affiliation":[{"name":"Instituto de Neurologia de Curitiba,  Brasil; Instituto de Neurologia de Curitiba,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugo Veroneze","family":"Toledo","sequence":"additional","affiliation":[{"name":"Instituto de Neurologia de Curitiba,  Brasil; Cl\u00ednica Paranaense de Tumores,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Ramina","sequence":"additional","affiliation":[{"name":"Instituto de Neurologia de Curitiba,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,4]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1002\/ana.410270114","article-title":"Incidence and clinical features of trigeminal neuralgia, Rochester, Minnesota, 1945-1984","volume":"27","author":"Katusic S","year":"1990","journal-title":"Ann Neurol"},{"issue":"15","key":"ref2","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1177\/0333102411424619","article-title":"Prevalence of trigeminal neuralgia and persistent idiopathic facial pain: a population-based study","volume":"31","author":"Mueller D","year":"2011","journal-title":"Cephalalgia"},{"issue":"Pt 4","key":"ref3","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1093\/brain\/123.4.665","article-title":"The incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK","volume":"123","author":"MacDonald BK","year":"2000","journal-title":"Brain"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1007\/s10194-006-0292-4","article-title":"The rare, unilateral headaches. 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