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Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT Chronic migraine poses a significant personal, social and economic burden and is characterized by headache present on 15 or more days per month for at least three months, with at least eight days of migrainous headache per month. It is frequently associated with analgesic or acute migraine medication overuse and this should not be overlooked. The present consensus was elaborated upon by a group of members of the Brazilian Headache Society in order to describe current evidence and to provide recommendations related to chronic migraine pharmacological and nonpharmacological treatment. Withdrawal strategies in medication overuse headache are also described, as well as treatment risks during pregnancy and breastfeeding. Oral topiramate and onabotulinum toxin A injections are the only treatments granted Class A recommendation, while valproate, gabapentin, and tizanidine received Class B recommendation, along with acupuncture, biofeedback, and mindfulness. The anti-CGRP or anti-CGRPr monoclonal antibodies, still unavailable in Brazil, are promising new drugs already approved elsewhere for migraine prophylactic treatment, the efficacy of which in chronic migraine is still to be definitively proven.<\/jats:p>","DOI":"10.1590\/0004-282x20190078","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T19:25:32Z","timestamp":1564255532000},"page":"509-520","source":"Crossref","is-referenced-by-count":27,"title":["Consensus of the Brazilian Headache Society on the treatment of chronic migraine"],"prefix":"10.1590","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0407-407X","authenticated-orcid":false,"given":"Fernando","family":"KOWACS","sequence":"first","affiliation":[{"name":"Academia Brasileira de Neurologia, Brasil; Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Brasil; Hospital Moinhos de Vento, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5557-6056","authenticated-orcid":false,"given":"C\u00e9lia Aparecida de Paula","family":"ROESLER","sequence":"additional","affiliation":[{"name":"Academia Brasileira de Neurologia, Brasil; Cl\u00ednica de Cefaleia e Neurologia Dr. Edgard Raffaelli, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0915-0430","authenticated-orcid":false,"given":"\u00c9lcio Juliato","family":"PIOVESAN","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4500-1376","authenticated-orcid":false,"given":"Elder Machado","family":"SARMENTO","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio de Volta Redonda, Brasil; Funda\u00e7\u00e3o Educacional Dom Andr\u00e9 Arcoverde, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0144-0687","authenticated-orcid":false,"given":"Henrique Carneiro de","family":"CAMPOS","sequence":"additional","affiliation":[{"name":"Santa Casa de Belo Horizonte, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7086-9623","authenticated-orcid":false,"given":"Jayme Antunes","family":"MACIEL JR","sequence":"additional","affiliation":[{"name":"Universidade de Campinas, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5758-5789","authenticated-orcid":false,"given":"Leandro Cortoni","family":"CALIA","sequence":"additional","affiliation":[{"name":"Hospital Israelita Albert Einstein, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9531-9115","authenticated-orcid":false,"given":"Liselotte Menke","family":"BAREA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3682-1228","authenticated-orcid":false,"given":"Marcelo Cedrinho","family":"CICIARELLI","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Bar\u00e3o de Mau\u00e1, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0678-3782","authenticated-orcid":false,"given":"Marcelo Moraes","family":"VALEN\u00c7A","sequence":"additional","affiliation":[{"name":"Universidade Federal de Pernambuco, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0052-5566","authenticated-orcid":false,"given":"Maria Eduarda Nobre de Magalh\u00e3es","family":"COSTA","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Neurol\u00f3gica Dra. 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