{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T04:29:22Z","timestamp":1754195362525,"version":"3.37.3"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"7","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT Because of the need for a standardized and accurate method for detecting multiple sclerosis (MS) inflammatory activity, different magnetic resonance (MR) acquisitions should be compared in order to choose the most sensitive sequence for clinical routine.  Objective  To compare the sensitivity of a T1-weighted image to a single dose of gadolinium (Gd) administration both with and without magnetization transfer to detect contrast enhancement in active demyelinating focal lesions.  Methods  A sample of relapsing-remitting MS patients were prospectively examined separately by two neuroradiologists using a 1.5 Tesla scanner. The outcome parameters were focused on Gd-enhancement detection attributed to acute demyelination. All MR examinations with at least one Gd-enhancing lesion were considered positive (MR+) and each lesion was analyzed according to its size and contrast ratio.  Results  Thirty-six MR examinations were analyzed with a high inter-observer agreement for MR+ detection (k coefficient &gt; 0.8), which was excellent for the number of Gd-enhancing lesions (0.91 T1 spin-echo (SE), 0.88 T1 magnetization transfer contrast (MTC) sequence and 0.99 magnetization-prepared rapid acquisition with gradient-echo (MPRAGE). Significantly more MR+ were reported on the T1 MTC scans, followed by the T1 SE, and MPRAGE scans. Confidently, the T1 MTC sequence demonstrated higher accuracy in the detection of Gd-enhancing lesions, followed by the T1 SE and MPRAGE sequences. Further comparisons showed that there was a statistically significant increase in the contrast ratio and area of Gd-enhancement on the T1 MTC images when compared with both the SE and MPRAGE images.  Conclusion  Single-dose Gd T1 MTC sequence was confirmed to be the most sensitive acquisition for predicting inflammatory active lesions using a 1.5 T magnet in this sample of MS patients.<\/jats:p>","DOI":"10.1590\/0004-282x20190082","type":"journal-article","created":{"date-parts":[[2019,7,27]],"date-time":"2019-07-27T15:30:25Z","timestamp":1564241425000},"page":"485-492","source":"Crossref","is-referenced-by-count":2,"title":["Improving acute demyelinating lesion detection: which T1-weighted magnetic resonance acquisition is more sensitive to gadolinium enhancement?"],"prefix":"10.1590","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2944-9947","authenticated-orcid":false,"given":"L\u00e1zaro Luiz Faria do","family":"AMARAL","sequence":"first","affiliation":[{"name":"Hospital Benefic\u00eancia Portuguesa de S\u00e3o Paulo,  Brasil; Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8458-428X","authenticated-orcid":false,"given":"Diego Cardoso","family":"FRAGOSO","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2591-9171","authenticated-orcid":false,"given":"Antonio Jos\u00e9 da","family":"ROCHA","sequence":"additional","affiliation":[{"name":"Irmandade da Santa Casa de Miseric\u00f3rdia de S\u00e3o Paulo,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,7]]},"reference":[{"issue":"8","key":"ref1","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1038\/nrneurol.2015.106","article-title":"MAGNIMS consensus guidelines on the use of MRI in multiple sclerosis-clinical implementation in the diagnostic process","volume":"11","author":"Rovira A","year":"2015","journal-title":"Nat Rev Neurol"},{"issue":"Pt 4","key":"ref2","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1093\/brain\/111.4.927","article-title":"Serial gadolinium enhanced magnetic resonance imaging in multiple sclerosis","volume":"111","author":"Miller DH","year":"1988","journal-title":"Brain"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/S1474-4422(17)30470-2","article-title":"Diagnosis of multiple sclerosis: 2017 revisions of the McDonald criteria","volume":"17","author":"Thompson AJ","year":"2018","journal-title":"Lancet Neurol"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1001\/archneurol.2009.49","article-title":"A single, early magnetic resonance imaging study in the diagnosis of multiple sclerosis","volume":"66","author":"Rovira A","year":"2009","journal-title":"Arch Neurol"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1017\/S0317167100014244","article-title":"Treatment optimization in MS: canadian MS Working Group updated recommendations","volume":"40","author":"Freedman MS","year":"2013","journal-title":"Can J Neurol Sci"},{"issue":"Pt 7","key":"ref6","doi-asserted-by":"crossref","first-page":"1149","DOI":"10.1093\/brain\/120.7.1149","article-title":"Sensitivity of contrast enhanced MRI in multiple sclerosis. 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