{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:22Z","timestamp":1787023042185,"version":"build-2736575974"},"reference-count":16,"publisher":"FapUNIFESP (SciELO)","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT The association between memory loss and Hodgkin's lymphoma has been given the eponym of Ophelia syndrome, in memory of Shakespeare's character in The Tragedy of Hamlet, Prince of Denmark. Nevertheless, there are differences between the disease and the character.  Objective: To review the origins and uses of the eponym through an original article by pathologist Ian Carr, its relation to the character Ophelia, and the related autoantibodies.  Methods: Historical narrative review.  Results: Besides an eloquent description in the original article, Carr presaged the presence of autoantibodies, before they had been thoroughly researched. Since then, five different autoantibodies (mGluR5, Hu, NMDAR, SOX, PCA2) have been associated with Hodgkin's disease. It is interesting to note the divergent outcomes of Shakespeare's character and the patient in the original description by Carr, the latter recovering to lead a normal life, and the former deceased.  Conclusions: Although there is little relationship between the fictional character and the syndrome, both imply the unintentional trigger of self-harm (suicide in one case, autoimmunity in the other), thus remaining associated.<\/jats:p>","DOI":"10.1590\/0004-282x20190105","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T09:30:43Z","timestamp":1575624643000},"page":"828-831","source":"Crossref","is-referenced-by-count":6,"title":["The poor insane Ophelia: reconsidering Ophelia syndrome"],"prefix":"10.1590","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9355-9716","authenticated-orcid":false,"given":"Carlos A.","family":"Soto-Rinc\u00f3n","sequence":"first","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon,  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4727-2535","authenticated-orcid":false,"given":"Sergio A.","family":"Castillo-Torres","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon,  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego A.","family":"Cant\u00fa-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon,  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ingrid","family":"Estrada-Bellmann","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon,  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Ch\u00e1vez-Lu\u00e9vanos","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon,  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Marfil","sequence":"additional","affiliation":[{"name":"Universidad Autonoma de Nuevo Leon,  Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,11]]},"reference":[{"issue":"8276","key":"ref1","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/S0140-6736(82)91887-6","article-title":"The Ophelia syndrome: memory loss in Hodgkin's disease","volume":"1","author":"Carr I","year":"1982","journal-title":"Lancet."},{"issue":"1-2","key":"ref2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1007\/BF00687044","article-title":"Immunocytochemical binding of serum IgG from a patient with oat cell tumor and paraneoplastic motoneuron disease to normal human cerebral cortex and molecular layer of the cerebellum","volume":"69","author":"Dhib-Jalbut S","year":"1986","journal-title":"Acta Neuropathol."},{"issue":"5","key":"ref3","first-page":"613","article-title":"[Implicaciones psiqui\u00e1tricas y neurol\u00f3gicas en la literatura shakespeariana","volume":"154","author":"L\u00f3pez-Vald\u00e9s JC","year":"2018","journal-title":"Breve an\u00e1lisis]. Gac Med Mex."},{"key":"ref4","series-title":"Hamlet, Prince of Denmark.","author":"Shakespeare W","year":"2003"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1084","DOI":"10.1136\/jnnp.53.12.1084","article-title":"Paraneoplastic limbic encephalitis: clinico-pathological correlations","volume":"53","author":"Bakheit AM","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry."},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1111\/j.1365-2141.1990.tb02571.x","article-title":"Hodgkin's disease and memory loss: another case of the Ophelia syndrome","volume":"74","author":"Pfliegler G","year":"1990","journal-title":"Br J Haematol."},{"key":"ref7","series-title":"L'Eau et les r\u00eaves: essai sur l'imagination de la mati\u00e8re.","author":"Bachelard G.","year":"1942"},{"key":"ref8","article-title":"When Shakespeare meets neurology: Hamlet, Ophelia and autoimmune encephalitis","author":"Imam I.","year":"2017","journal-title":"Neurol Lounge."},{"key":"ref9","series-title":"Siete noches.","first-page":"301","volume-title":"La ceguera","volume":"3","author":"Borges JL","year":"2011"},{"issue":"18","key":"ref10","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1212\/WNL.0b013e3182364a44","article-title":"Antibodies to metabotropic glutamate receptor 5 in the Ophelia syndrome","volume":"77","author":"Lancaster E","year":"2011","journal-title":"Neurology."},{"issue":"14","key":"ref11","doi-asserted-by":"crossref","first-page":"1349","DOI":"10.1212\/WNL.0b013e31828ab325","article-title":"Ophelia syndrome with metabotropic glutamate receptor 5 antibodies in CSF","volume":"80","author":"Mat A","year":"2013","journal-title":"Neurology."},{"issue":"15","key":"ref12","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1212\/WNL.0000000000000865","article-title":"Limbic encephalitis with mGluR5 antibodies and immunotherapy-responsive prosopagnosia","volume":"83","author":"Pruss H","year":"2014","journal-title":"Neurology."},{"issue":"12","key":"ref13","doi-asserted-by":"crossref","first-page":"2374","DOI":"10.1080\/10428190802419657","article-title":"Hu-antibody positive limbic encephalitis in a patient with Hodgkin lymphoma","volume":"49","author":"Hentschke S","year":"2008","journal-title":"Leuk Lymphoma."},{"issue":"7","key":"ref14","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3109\/10428194.2011.645211","article-title":"Anti-Hu-associated paraneoplastic limbic encephalitis in Hodgkin lymphoma","volume":"53","author":"Laffon M","year":"2012","journal-title":"Leuk Lymphoma."},{"issue":"23","key":"ref15","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1212\/WNL.0b013e3181c55e9b","article-title":"Limbic encephalitis associated with antibodies to the NMDA receptor in Hodgkin lymphoma","volume":"73","author":"Zandi MS","year":"2009","journal-title":"Neurology."},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1016\/j.ejpn.2017.03.005","article-title":"Paraneoplastic limbic encephalitis with SOX1 and PCA2 antibodies and relapsing neurological symptoms in an adolescent with Hodgkin lymphoma","volume":"21","author":"Kunstreich M","year":"2017","journal-title":"Eur J Paediatr Neurol."}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v77n11\/1678-4227-anp-77-11-0828.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T19:34:26Z","timestamp":1596224066000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2019001100828&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":16,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["S0004-282X2019001100828"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20190105","relation":{},"ISSN":["1678-4227","0004-282X"],"issn-type":[{"value":"1678-4227","type":"electronic"},{"value":"0004-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2019,11]]}}}