{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T06:06:02Z","timestamp":1773813962223,"version":"3.50.1"},"reference-count":19,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT First described by Retzius at the end of the 19th century, the structure in the posterior medulla oblongata, then named area postrema, underwent an intense investigation into its function in the decades that followed. Findings, mainly in animal studies, have partially elucidated its role as an emetic center in the central nervous system. In the second half of the 20th century, this function was associated with reports of syndromes characterized by uncontrollable nausea and vomiting related to structural damage in the area postrema, mainly in the context of demyelinating diseases. At the beginning of the 21st century, the so-called area postrema syndrome has been consolidated as a diagnostic factor in diseases related to the spectrum of neuromyelitis optica, more than 100 years after its first description.<\/jats:p>","DOI":"10.1590\/0004-282x20190118","type":"journal-article","created":{"date-parts":[[2020,1,21]],"date-time":"2020-01-21T09:51:07Z","timestamp":1579600267000},"page":"121-123","source":"Crossref","is-referenced-by-count":7,"title":["A concise historical perspective of the area postrema structure and function"],"prefix":"10.1590","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3695-5752","authenticated-orcid":false,"given":"Thiago Ferreira Sim\u00f5es","family":"DE SOUZA","sequence":"first","affiliation":[{"name":"Hospital da Cruz Vermelha Brasileira,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,2]]},"reference":[{"key":"ref1","first-page":"1","article-title":"Untersuchungen \u00fcber die Organe welche an dem Brechact theilnehmen und \u00fcber die physiologische Wirkung des Tartarus stibiatus","volume":"3","author":"Giannuzzi G","year":"1865","journal-title":"Zentr Med Wiis"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/BF01881928","article-title":"Ueber das Brechcentrum und \u00fcber die Wirkung einiger pharmakologischer Mittel auf dasselbe","volume":"123","author":"Thumas LJ","year":"1891","journal-title":"Arch F Path Anat U Physiol"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1080\/09647040701236578","article-title":"Area postrema: one of the terms described by Magnus Gustaf Retzius","volume":"17","author":"Sarikcioglu L","year":"2008","journal-title":"J Hist Neurosci"},{"issue":"1-2","key":"ref4","first-page":"64","article-title":"[The histologist and anatomist Gustaf Retzius. 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