{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,19]],"date-time":"2025-03-19T16:19:16Z","timestamp":1742401156768,"version":"3.37.3"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"11","license":[{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,11,1]],"date-time":"2019-11-01T00:00:00Z","timestamp":1572566400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT Falls are common among persons with Parkinson's disease (PD). On the other hand, predicting falls is complex as there are both generic and PD-specific contributors. In particular, the role of non-motor symptoms has been less studied.  Objective: The objective of this study was to identify the role of non-motor predictors of falling in persons with PD (PwP).  Methods: A cross-sectional study was carried out in PwP recruited from a movement disorders clinic. Clinical and demographical data were collected. All PwP were assessed using the Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) and the Non-Motor Symptoms Scale (NMSS). Variables were assessed at the bivariate level. Significant variables were put into a logistic regression model.  Results: A total of 179 PwP were included. Overall, 16.8% of PwP had fallen in the past 12 months, with 53.3% of them being recurrent fallers. The mean number of monthly falls was 2.5 \u00b1 3.3. Factors associated with falling in the bivariate analysis included the disease duration, Hoehn and Yahr stage, MDS-UPDRS part I and II, postural instability\/gait disturbance (PIGD) subtype, NMSS urinary domain, NMSS miscellaneous domain, and non-motor severity burden (all p-values &lt; 0.05). After multivariate analysis, only the disease duration (p = 0.03) and PIGD (p = 0.03) remained as independent risk factors.  Conclusion: Disease duration and the PIGD subtype were identified as relevant risk factors for falls in PwP Non-motor symptoms appear to have a less important role as risk factors for falls.<\/jats:p>","DOI":"10.1590\/0004-282x20190148","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T14:32:03Z","timestamp":1575642723000},"page":"761-767","source":"Crossref","is-referenced-by-count":3,"title":["Falls in persons with Parkinson's disease: Do non-motor symptoms matter as much as motor symptoms?"],"prefix":"10.1590","volume":"77","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8088-4907","authenticated-orcid":false,"given":"Alonso","family":"Alvarado-Bola\u00f1os","sequence":"first","affiliation":[{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3935-9278","authenticated-orcid":false,"given":"Amin","family":"Cervantes-Arriaga","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenia","family":"Arredondo-Blanco","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karla","family":"Salinas-Barboza","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Isais-Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6041-9941","authenticated-orcid":false,"given":"Mayela","family":"Rodr\u00edguez-Violante","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda,  Mexico; Instituto Nacional de Neurolog\u00eda y Neurocirug\u00eda,  Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,11]]},"reference":[{"key":"ref1","first-page":"906274","article-title":"Recurrent falls in Parkinson's disease: a systematic review","volume":"2013","author":"Allen NE","year":"2013","journal-title":"Parkinsons Dis"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1212\/01.wnl.0000299085.18976.20","article-title":"Practice parameter: assessing patients in a neurology practice for risk of falls (an evidence-based review): report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"70","author":"Thurman DJ","year":"2008","journal-title":"Neurology"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.parkreldis.2013.10.030","article-title":"Consensus-based clinical practice recommendations for the examination and management of falls in patients with Parkinson's disease","volume":"20","author":"Marck MA","year":"2014","journal-title":"Parkinsonism Relat Disord"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1002\/mds.26424","article-title":"MDS clinical diagnostic criteria for Parkinson's disease","volume":"30","author":"Postuma RB","year":"2015","journal-title":"Mov Disord"},{"issue":"15","key":"ref5","doi-asserted-by":"crossref","first-page":"2649","DOI":"10.1002\/mds.23429","article-title":"Systematic review of levodopa dose equivalency reporting in Parkinson's disease","volume":"25","author":"Tomlinson CL","year":"2010","journal-title":"Mov Disord"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1212\/WNL.50.2.318","article-title":"Parkinsonism: onset, progression, and mortality. 1967","volume":"50","author":"Hoehn MM","year":"1998","journal-title":"Neurology"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1007\/s00415-012-6624-1","article-title":"Expanded and independent validation of the Movement Disorder Society-Unified Parkinson's Disease Rating Scale (MDS-UPDRS)","volume":"260","author":"Martinez-Martin P","year":"2013","journal-title":"J Neurol"},{"issue":"13","key":"ref8","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1002\/mds.21596","article-title":"The metric properties of a novel non-motor symptoms scale for Parkinson's disease: results from an international pilot study","volume":"22","author":"Chaudhuri KR","year":"2007","journal-title":"Mov Disord"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1002\/mds.25383","article-title":"How to identify tremor dominant and postural instability\/gait difficulty groups with the movement disorder society unified Parkinson's disease rating scale: comparison with the unified Parkinson's disease rating scale","volume":"28","author":"Stebbins GT","year":"2013","journal-title":"Mov Disord"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0057221","article-title":"A proposal for a comprehensive grading of Parkinson's disease severity combining motor and non-motor assessments: meeting an unmet need","volume":"8","author":"Ray Chaudhuri K","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.parkreldis.2014.12.031","article-title":"The burden of non-motor symptoms in Parkinson's disease using a self-completed non-motor questionnaire: a simple grading system","volume":"21","author":"Chaudhuri KR","year":"2015","journal-title":"Parkinsonism Relat Disord"},{"issue":"13","key":"ref12","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1002\/mds.21598","article-title":"A meta-analysis of six prospective studies of falling in Parkinson's disease","volume":"22","author":"Pickering RM","year":"2007","journal-title":"Mov Disord"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"15011","DOI":"10.1038\/npjparkd.2015.11","article-title":"Why do patients with Parkinson's disease fall? 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