{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T06:25:51Z","timestamp":1762928751346,"version":"3.37.3"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,2,1]],"date-time":"2020-02-01T00:00:00Z","timestamp":1580515200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>Abstract Neurocysticercosis (NCC) is classified as a neglected tropical disease, which affects mainly Latin America and Africa in spite of some reports in North America and Europe. NCC represents the cause of up to 30% of the reported cases of epilepsy in endemic countries. The NCC injuries present direct relation to the development stage, location, and number of parasites as well as to the host immune response. This study aimed the characterization of the inflammatory response and tissue injuries by means of the analyses of the periventricular and parenchymatous demyelination through the experimental intraventricular NCC infection. Therefore, BALB\/c mice were submitted to experimental NCC inoculation with Taenia crassiceps cysticerci. Their brains were removed at 7, 30, 60, and 90 days after the inoculation (DAI), and analyzed after staining with hematoxylin and eosin (HE), Luxol Fast Blue, and Nissl. It was possible to observe ventriculomegaly, inflammatory infiltration composed by polymorphonuclear and mononuclear cells, and foamy macrophages. The presence of inflammatory cells was associated with neurodegeneration detected by the areas with demyelination observed initially in the periventricular area and lately in the parenchyma. In conclusion, the presence of cysticerci and the consequent inflammation were able to promote initial periventricular demyelination followed by parenchymatous demyelination as the infection progressed.<\/jats:p>","DOI":"10.1590\/0004-282x20190155","type":"journal-article","created":{"date-parts":[[2020,2,3]],"date-time":"2020-02-03T18:14:12Z","timestamp":1580753652000},"page":"103-111","source":"Crossref","is-referenced-by-count":5,"title":["Demyelination in experimental intraventricular neurocysticercosis"],"prefix":"10.1590","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0805-7197","authenticated-orcid":false,"given":"Vania Beatriz Lopes","family":"MOURA","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6264-8695","authenticated-orcid":false,"given":"Analia Cirqueira","family":"MILHOMEM","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1000-2486","authenticated-orcid":false,"given":"Sarah Buzaim","family":"LIMA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2306-2864","authenticated-orcid":false,"given":"Hidelberto","family":"MATOS-SILVA","sequence":"additional","affiliation":[{"name":"Universidade de Rio Verde, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8592-7002","authenticated-orcid":false,"given":"Denis Masashi","family":"SUGITA","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6746-9191","authenticated-orcid":false,"given":"Mariana Clare","family":"VINAUD","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0572-5102","authenticated-orcid":false,"given":"Ruy de Souza","family":"LINO-J\u00daNIOR","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,2]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1186\/s13071-017-2280-8","article-title":"Epidemiology of taeniosis\/cysticercosis in Europe, a systematic review: Western Europe","volume":"10","author":"Laranjo-Gonz\u00e1lez M","year":"2017","journal-title":"Parasit Vectors"},{"series-title":"Developing surveillance indicators to measure global progress against pork tapeworm","key":"ref2"},{"key":"ref3","first-page":"143","article-title":"Epidemiology of neurocysticercosis and epilepsy, is everything described?","volume":"76","author":"Tellez-Zenteno JF","year":"2017","journal-title":"Epilepsy Behav"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/pim.12299","article-title":"Immunopathology in Taenia solium neurocysticercosis","volume":"38","author":"Fleury A","year":"2016","journal-title":"Parasite Immunol"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3171\/foc.2002.12.6.2","article-title":"Review of neurocysticercosis","volume":"12","author":"Sotelo J","year":"2002","journal-title":"Neurosurg Focus"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1590\/S0004-282X2007000100025","article-title":"Perfil cl\u00ednico-epidemiol\u00f3gico de pacientes com NCC atendidos no Hospital Universit\u00e1rio Regional de Maring\u00e1, Paran\u00e1, Brasil","volume":"65","author":"Benedeti MR","year":"2007","journal-title":"Arq Neuropsiquiatr"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"995","DOI":"10.4049\/jimmunol.162.2.995","article-title":"Development of an animal model for neurocysticercosis: immune response in the central nervous system is characterized by a predominance of gamma delta T cells","volume":"162","author":"Cardona AE","year":"1999","journal-title":"J. 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