{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T21:19:45Z","timestamp":1767993585509,"version":"3.49.0"},"reference-count":25,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,4,1]],"date-time":"2020-04-01T00:00:00Z","timestamp":1585699200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>Abstract  Objective:  The effects of vitamin D on the central and peripheral nervous system continue to be investigated today. In the present study, we aimed to evaluate pain and electrophysiologic response in patients with carpal tunnel syndrome (CTS) who have undergone replacement therapy due to vitamin D deficiency.  Methods:  Fifty female patients diagnosed with mild and moderate CTS and accompanied by vitamin D deficiency were included in this study. Nerve conduction study (NCS) was performed before and after vitamin D replacement, and the patient\u2019s pain was evaluated with Visual Analogue Scale (VAS).  Results:  When NCS were compared before and after treatment, there was a statistically significant improvement in the median distal sensory onset latency (DSOL) and sensory conduction velocity (CV) and motor distal latencies (DML) values (p=0.001; p&lt;0.001; p=0.001, respectively). At the same time, there was a decrease in the VAS values in patients (p&lt;0.001). When the two groups were compared there was an improvement in DSOL and sensory CV in both groups, but in DML only in moderate CTS group.  Conclusion:  In this study, it was shown that mild and moderate CTS patients had an improvement in pain and electrophysiological parameters after vitamin D replacement. Replacing vitamin D in early stages of CTS may be beneficial.<\/jats:p>","DOI":"10.1590\/0004-282x20190193","type":"journal-article","created":{"date-parts":[[2020,4,11]],"date-time":"2020-04-11T19:30:14Z","timestamp":1586633414000},"page":"224-229","source":"Crossref","is-referenced-by-count":7,"title":["Electrophysiological evaluation of carpal tunnel syndrome female patients after vitamin D replacement"],"prefix":"10.1590","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1480-0562","authenticated-orcid":false,"given":"Hikmet","family":"SA\u00c7MACI","sequence":"first","affiliation":[{"name":"Yozgat Bozok University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7567-9244","authenticated-orcid":false,"given":"Nermin","family":"TANIK","sequence":"additional","affiliation":[{"name":"Yozgat Bozok University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2813-3406","authenticated-orcid":false,"given":"\u00d6zlem","family":"BALBALO\u011eLU","sequence":"additional","affiliation":[{"name":"Yozgat Bozok University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1818-1578","authenticated-orcid":false,"given":"T\u00fclin","family":"AKT\u00dcRK","sequence":"additional","affiliation":[{"name":"Yozgat Bozok University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2441-0624","authenticated-orcid":false,"given":"Levent Ertu\u011frul","family":"\u0130NAN","sequence":"additional","affiliation":[{"name":"Yozgat Bozok University,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,4]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s41983-018-0009-z","article-title":"Body mass index and vitamin D level in carpal tunnel syndrome patients","volume":"54","author":"Nageeb RS","year":"2018","journal-title":"Egypt J Neurol Psychiatr Neurosurg"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1515\/sjpain-2018-0089","article-title":"Diagnosis of carpal tunnel syndrome","volume":"18","author":"Kleggetveit IP","year":"2018","journal-title":"Scand J Pain"},{"issue":"1","key":"ref3","first-page":"4","article-title":"Pathophysiology of carpal tunnel syndrome","volume":"20","author":"Aboonq MS","year":"2015","journal-title":"Neurosciences (Riyadh)"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3233\/BMR-160696","article-title":"Does vitamin D deficiency trigger carpal tunnel syndrome?","volume":"29","author":"Tanik N","year":"2016","journal-title":"J Back Musculoskelet Rehabil"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1007\/s00296-014-3099-7","article-title":"Hypovitaminosis D in widespread pain: its effect on pain perception, quality of life and nerve conduction studies","volume":"35","author":"Kuru P","year":"2015","journal-title":"Rheumatol Int"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.neurol.2015.11.005","article-title":"Vitamin D deficiency and its role in neurological conditions: A review","volume":"172","author":"Mpandzou G","year":"2016","journal-title":"Rev Neurol (Paris)"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"2815","DOI":"10.1007\/s00405-014-3305-y","article-title":"Vitamin D3 potentiates myelination and recovery after facial nerve injury","volume":"272","author":"Montava M","year":"2015","journal-title":"Eur Arch Otorhinolaryngol"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1089\/neu.2008.0593","article-title":"Vitamin D2 potentiates axon regeneration","volume":"25","author":"Chabas J-F","year":"2008","journal-title":"J Neurotrauma"},{"issue":"39","key":"ref9","doi-asserted-by":"crossref","first-page":"13728","DOI":"10.1523\/JNEUROSCI.3637-11.2011","article-title":"Vitamin D deficiency promotes skeletal muscle hypersensitivity and sensory hyperinnervation","volume":"31","author":"Tague SE","year":"2011","journal-title":"J Neurosci"},{"issue":"1-2","key":"ref10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.jns.2011.07.033","article-title":"Vitamin D in the healthy and inflamed central nervous system: access and function","volume":"311","author":"Smolders J","year":"2011","journal-title":"J Neurol Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"S265","DOI":"10.1016\/j.psyneuen.2009.05.023","article-title":"Vitamin D, a neuro-immunomodulator: implications for neurodegenerative and autoimmune diseases","volume":"34","author":"de Abreu DF","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1159\/000375304","article-title":"Prospective evaluation of the effect of short-term oral vitamin D supplementation on peripheral neuropathy in type 2 diabetes mellitus","volume":"24","author":"Shehab D","year":"2015","journal-title":"Med Princ Pract"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0304-3959(87)91074-8","article-title":"The short-form McGill pain questionnaire","volume":"30","author":"Melzack R","year":"1987","journal-title":"Pain"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1002\/mus.10185","article-title":"Practice parameter for electrodiagnostic studies in carpal tunnel syndrome: summary statement","volume":"25","year":"2002","journal-title":"Muscle Nerve"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1002\/mus.22208","article-title":"Electrodiagnostic evaluation of carpal tunnel syndrome","volume":"44","author":"Werner RA","year":"2011","journal-title":"Muscle Nerve"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1288\/00005537-197101000-00001","article-title":"Reinnervation of the facial muscles following extratemporal facial nerve resection","volume":"81","author":"McCoy EG","year":"1971","journal-title":"Laryngoscope"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1097\/00005537-200004000-00023","article-title":"Rabbit facial nerve regeneration in autologous nerve grafts after antecedent injury","volume":"110","author":"Spector JG","year":"2000","journal-title":"Laryngoscope"},{"issue":"5","key":"ref18","article-title":"Cholecalciferol (vitamin D3) improves myelination and recovery after nerve injury","volume":"8","author":"Chabas J-F","year":"2013","journal-title":"PLoS ONE"},{"issue":"3-5","key":"ref19","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.jsbmb.2006.12.096","article-title":"Developmental vitamin D deficiency alters the expression of genes encoding mitochondrial, cytoskeletal and synaptic proteins in the adult rat brain","volume":"103","author":"Eyles D","year":"2007","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1177\/1753193417749158","article-title":"Expression of vitamin D receptor in the subsynovial connective tissue in women with carpal tunnel syndrome","volume":"43","author":"Kim K","year":"2018","journal-title":"J J Hand Surg Eur Vol"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1080\/1028415X.2018.1435485","article-title":"Vitamin D supplementation attenuates the behavioral scores of neuropathic pain in rats","volume":"22","author":"Banafshe HR","year":"2019","journal-title":"Nutr Neurosci"},{"issue":"1-4","key":"ref22","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0169-328X(94)90119-8","article-title":"1, 25-dihydroxyvitamin D3 regulates the synthesis of nerve growth factor in primary cultures of glial cells","volume":"24","author":"Neveu I","year":"1994","journal-title":"Brain Res Mol Brain Res"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1097\/MRR.0000000000000211","article-title":"The effect of vitamin D supplementation on pain, quality of life, and nerve conduction studies in women with chronic widespread pain","volume":"40","author":"Akyuz G","year":"2017","journal-title":"Int J Rehabil Res"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1177\/1753193415622732","article-title":"Evaluation of vitamin D levels in women with carpal tunnel syndrome","volume":"41","author":"Lee SH","year":"2016","journal-title":"J Hand Surg Eur Vol"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1016\/j.otsr.2017.05.003","article-title":"The effect of vitamin D levels on pain in carpal tunnel syndrome","volume":"103","author":"Demiryurek B","year":"2017","journal-title":"Orthop Traumatol Surg Res"}],"container-title":["Arquivos de Neuro-Psiquiatria"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/anp\/v78n4\/1678-4227-anp-0004-282x20190193.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,1,23]],"date-time":"2021-01-23T17:59:18Z","timestamp":1611424758000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0004-282X2020000400224&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,4]]},"references-count":25,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2020,4]]}},"alternative-id":["S0004-282X2020000400224"],"URL":"https:\/\/doi.org\/10.1590\/0004-282x20190193","relation":{},"ISSN":["1678-4227","0004-282X"],"issn-type":[{"value":"1678-4227","type":"electronic"},{"value":"0004-282X","type":"print"}],"subject":[],"published":{"date-parts":[[2020,4]]}}}