{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T03:14:26Z","timestamp":1776914066564,"version":"3.51.2"},"reference-count":24,"publisher":"FapUNIFESP (SciELO)","issue":"12","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Arq. Neuro-Psiquiatr."],"abstract":"<jats:p>ABSTRACT  Objective:  Uric acid has been shown to be related to the severity of obstructive sleep apnoea syndrome (OSAS) in adults. We assessed the role of uric acid in OSAS in a cohort of older patients.  Methods:  A total of 164 patients aged &gt;65 years, admitted to our sleep laboratory between January 1st, 2016 and July 1st, 2018 with a complaint of snoring, underwent overnight polysomnography and were retrospectively evaluated.  Results:  A total of 126 patients who fulfilled the inclusion criteria (mean age 69.16\u00b13.68 years, 56% men) were included. The control group was comprised of 14 patients, while the OSAS group consisted of 112 patients (31 mild, 44 moderate and 37 severe cases). No differences were observed in age, sex, hip circumference, waist\/hip ratio or comorbidities between the groups. The Epworth Sleepiness Scale score, body mass index (BMI), and waist circumference were significantly higher in OSAS patients than in controls (p=0.001, p=0.02, and p=0.36, respectively). Uric acid was not correlated with any of the sleep parameters, and no significant differences were detected between the groups. Hyperuricemic patients were similar in terms of sleep parameters and comorbidities in comparison with the other patients.  Conclusions:  No relationship was observed between uric acid level and OSAS severity, as defined by the apnoea-hypopnea index. Further studies are needed to determine the value of uric acid as a marker of OSAS, after controlling for cardiovascular comorbidities, in older patients with this syndrome.<\/jats:p>","DOI":"10.1590\/0004-282x20200069","type":"journal-article","created":{"date-parts":[[2020,12,14]],"date-time":"2020-12-14T19:27:52Z","timestamp":1607974072000},"page":"783-788","source":"Crossref","is-referenced-by-count":6,"title":["Uric acid as a marker of severity of obstructive sleep apnoea syndrome in older patients"],"prefix":"10.1590","volume":"78","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7184-2075","authenticated-orcid":false,"given":"Sinem Nedime","family":"S\u00d6K\u00dcC\u00dc","sequence":"first","affiliation":[{"name":"Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9816-8885","authenticated-orcid":false,"given":"Cengiz","family":"\u00d6ZDEM\u0130R","sequence":"additional","affiliation":[{"name":"Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4460-9056","authenticated-orcid":false,"given":"\u015eenay","family":"AYDIN","sequence":"additional","affiliation":[{"name":"Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0657-0392","authenticated-orcid":false,"given":"Seda Tural","family":"\u00d6N\u00dcR","sequence":"additional","affiliation":[{"name":"Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6043-532X","authenticated-orcid":false,"given":"\u00d6zlem","family":"KAHYA","sequence":"additional","affiliation":[{"name":"Yedikule Chest Disease and Thoracic Surgery Training and Research Hospital,  Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,12]]},"reference":[{"issue":"9","key":"ref1","first-page":"1155","article-title":"Obstructive sleep apnea: diagnosis, epidemiology, and economics","volume":"55","author":"Kapur VK","year":"2010","journal-title":"Respir Care"},{"issue":"5","key":"ref2","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.pcad.2008.08.002","article-title":"Endothelial function in obstructive sleep apnea","volume":"51","author":"Atkeson A","year":"2009","journal-title":"Prog Cardiovasc Dis"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1111\/jgs.13607","article-title":"High serum uric acid levels are associated with all-cause and cardiovascular, but not Cancer, mortality in elderly adults","volume":"63","author":"Wu CY","year":"2015","journal-title":"J Am Geriatr Soc"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1811","DOI":"10.1056\/NEJMra0800885","article-title":"Uric acid and cardiovascular risk","volume":"359","author":"Feig DI","year":"2008","journal-title":"N Engl J Med"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1161\/01.RES.87.10.840","article-title":"Endothelial dysfunction in cardiovascular diseases: the role of oxidant stress","volume":"87","author":"Cai H","year":"2000","journal-title":"Circ Res"},{"issue":"18","key":"ref6","doi-asserted-by":"crossref","first-page":"2404","DOI":"10.1001\/jama.283.18.2404","article-title":"Serum uric acid and cardiovascular mortality the NHANES I epidemiologic follow-up study, 1971-1992. 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