{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T17:57:35Z","timestamp":1763747855463,"version":"build-2065373602"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Enferm."],"abstract":"<jats:p>ABSTRACT  Objective: To evaluate the antioxidant action of N-acetylcysteine and diosmin-hesperidin in an experimental model of sepsis-induced acute kidney injury in rats.  Methods: The study used 20 Wistar adult male rats divided into the following groups: control (laparotomy with no induction of abdominal sepsis), sepsis (experimental model of sepsis with cecal ligation and puncture), N-acetylcysteine + sepsis and diosmin-hesperidin + sepsis. The evaluation contemplated physiological parameters (temperature, glycemia, and average blood pressure), kidney function (creatinine clearance), oxidative stress (urinary peroxides) and kidney histology.  Results: The animals submitted to cecal ligation and puncture (sepsis) presented lower body temperature, lower average blood pressure, reduced creatinine clearance and increased urinary hydrogen peroxide levels. Treatment with diosmin-hesperidin improved kidney function and led to a reduction in the excretion of oxidative metabolites.  Conclusion: The present study highlighted the protective antioxidant action of diosmin-hesperidin in the experimental model of sepsis-induced acute kidney injury.<\/jats:p>","DOI":"10.1590\/0034-7167-2017-0469","type":"journal-article","created":{"date-parts":[[2018,8,28]],"date-time":"2018-08-28T18:11:30Z","timestamp":1535479890000},"page":"1921-1927","source":"Crossref","is-referenced-by-count":18,"title":["Sepsis-induced acute kidney injury: kidney protection effects by antioxidants"],"prefix":"10.1590","volume":"71","author":[{"given":"Carolina Ferreira","family":"Vasco","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mirian","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cassiane Dezoti da","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria de F\u00e1tima Fernandes","family":"Vattimo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,8]]},"reference":[{"key":"ref1","article-title":"Epidemiology of acute kidney injury in the intensive care unit","author":"Case J","year":"2013","journal-title":"Crit Care Res Pract"},{"key":"ref2","first-page":"1","article-title":"KDIGO Clinical Practice Guidelines for Acute Kidney Injury","volume":"2","year":"2012","journal-title":"Kidney Int Suppl"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/S0140-6736(13)60647-9","article-title":"Acute kidney injury: an increasing global concern","volume":"382","author":"Lameire NH","year":"2013","journal-title":"Lancet"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1007\/s00134-017-4755-7","article-title":"Acute kidney injury in sepsis","volume":"43","author":"Bellomo R","year":"2017","journal-title":"Intensive Care Med"},{"issue":"8","key":"ref5","doi-asserted-by":"crossref","first-page":"801","DOI":"10.1001\/jama.2016.0287","article-title":"The third international consensus definitions for sepsis and septic shock (Sepsis-3)","volume":"315","author":"Singer M","year":"2016","journal-title":"JAMA"},{"issue":"7","key":"ref6","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1111\/aas.12133","article-title":"Acute kidney injury in patients with severe sepsis in Finnish Intensive Care Units","volume":"57","author":"Poukkanen M","year":"2013","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1001\/jama.2016.10485","article-title":"Effect of early vasopressin vs norepinephrine on kidney failure in patients with septic shock: the VANISH randomized clinical trial","volume":"316","author":"Gordon AC","year":"2016","journal-title":"JAMA"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1186\/cc10334","article-title":"Bench-to-bedside review: sepsis-from the redox point of view","volume":"15","author":"Andrades ME","year":"2011","journal-title":"Crit Care"},{"issue":"Spec","key":"ref9","first-page":"74","article-title":"Prevention of amphotericin B nephrotoxicity through use of phytotherapeutic medication","volume":"49","author":"Schlottfeldt FS","year":"2015","journal-title":"Rev Esc Enferm USP"},{"issue":"5","key":"ref10","first-page":"783","article-title":"Hydration and N-acetylcysteine in acute renal failure caused by iodinated contrast medium: an experiment with rats","volume":"21","author":"Pinto CF","year":"2008","journal-title":"J Nephrol"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1590\/S0102-865020150080000008","article-title":"Copaiba oil effect on induced fecal peritonitis in rats","volume":"30","author":"Lopes LN","year":"2015","journal-title":"Acta Cir Bras"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"5082","DOI":"10.1128\/AAC.00925-12","article-title":"Role of heme oxygenase-1 in polymyxin B-induced nephrotoxicity in rats","volume":"56","author":"Dezoti Fonseca C","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"1\/2","key":"ref13","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S0009-8981(03)00236-5","article-title":"Urinary hydrogen peroxide: a probably marker of oxidative stress in malignancy","volume":"334","author":"Banerjee D","year":"2003","journal-title":"Clin Chim Acta"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1089\/sur.2015.072","article-title":"Antioxidant effects of probiotics in experimentally induced peritonitis","volume":"17","author":"Erginel B","year":"2016","journal-title":"Surg Infect"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2868","DOI":"10.1172\/JCI39421","article-title":"Animal models of sepsis and sepsis-induced kidney injury","volume":"119","author":"Doi K","year":"2009","journal-title":"J Clin Invest"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1002022","article-title":"The clinical challenge of sepsis identification and monitoring","volume":"13","author":"Vincent JL","year":"2016","journal-title":"PLoS Med"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"F209","DOI":"10.1152\/ajprenal.00687.2010","article-title":"Hemodynamic changes in the kidney in a pediatric rat model of sepsis-induced acute kidney injury","volume":"301","author":"Seely KA","year":"2011","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref18","doi-asserted-by":"crossref","DOI":"10.1186\/cc13106","article-title":"JAAM Sepsis Registry Study Group: The impact of body temperature abnormalities on the disease severity and outcome in patients with severe sepsis: an analysis from a multicenter, prospective survey of severe sepsis","author":"Kushimoto S","year":"2013","journal-title":"Crit Care"},{"issue":"4","key":"ref19","article-title":"Modulation of early inflammatory response by different balanced and non-balanced colloids and crystalloids in a rodent model of endotoxemia","volume":"9","author":"Graggen B","year":"2014","journal-title":"PLoS One"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"R58","DOI":"10.1186\/cc11301","article-title":"Correlation between high blood IL-6 level, hyperglycemia, and glucose control in septic patients","volume":"16","author":"Nakamura M","year":"2012","journal-title":"Crit Care"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1590\/0034-7167-2016-0266","article-title":"Nursing Activities Score and Acute Kidney Injury","volume":"70","author":"Coelho FUA","year":"2017","journal-title":"Rev Bras Enferm"},{"key":"ref22","first-page":"86","article-title":"The sepsis as cause of acute kidney injury: an experimental model","volume":"46","author":"Pinto CF","year":"2012","journal-title":"Rev Esc Enferm USP"},{"issue":"20","key":"ref23","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.jacc.2009.08.091","article-title":"Impact of high-dose N-acetylcysteine versus placebo on contrast-induced nephropathy and myocardial reperfusion injury in unselected patients with ST-segment elevation myocardial infarction undergoing primary percutaneous coronary intervention. The LIPSIA-N-ACC (Prospective, Single-Blind, Placebo-Controlled, Randomized Leipzig Immediate PercutaneouS Coronary Intervention Acute Myocardial Infarction N-ACC) Trial","volume":"55","author":"Thiele H","year":"2010","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"E16","DOI":"10.1532\/hsf.1424","article-title":"N-Acetyl Cysteine therapy does not prevent renal failure in high-risk patients undergoing open-heart surgery","volume":"19","author":"Rababa'h AM","year":"2016","journal-title":"Heart Surg Forum"},{"issue":"9","key":"ref25","article-title":"Do intravenous N-acetylcysteine and sodium bicarbonate prevent high osmolal contrast-induced acute kidney injury? a randomized controlled trial","volume":"9","author":"Inda-Filho AJ","year":"2014","journal-title":"PLoS One"},{"issue":"15","key":"ref26","doi-asserted-by":"crossref","first-page":"1566","DOI":"10.1001\/jama.2012.13356","article-title":"Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults","volume":"308","author":"Yunos NM","year":"2012","journal-title":"JAMA"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1016\/j.freeradbiomed.2008.09.003","article-title":"The mitochondria-targeted antioxidant MitoQ protects against organ damage in a lipopolysaccharide-peptidoglycan model of sepsis","volume":"45","author":"Lowes DA","year":"2008","journal-title":"Free Radic Biol Med"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1080\/10715760802438709","article-title":"The oxidative stress and the mitochondrial dysfunction caused by endotoxemia are prevented by \u03b1-lipoic acid","volume":"42","author":"Vanasco V","year":"2008","journal-title":"Free Rad Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"F532","DOI":"10.1152\/ajprenal.00323.2002","article-title":"Interaction among nitric oxide, reaction oxygen species, and antioxidants during endotoxemia-related acute renal failure","volume":"284","author":"Wang W","year":"2003","journal-title":"Am J Physiol Renal Physiol"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1590\/S0080-6234201400005000007","article-title":"Antioxidant protection of statins in acute kidney injury induced by sepsis","volume":"48","author":"Santos FN","year":"2014","journal-title":"Rev Esc Enferm USP"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1260","DOI":"10.1016\/j.bcp.2010.06.027","article-title":"Resveratrol, a dietary polyphenolic phytoalexin, is a functional scavenger of peroxynitrite","volume":"80","author":"Holthoff JH","year":"2010","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/j.phymed.2012.12.001","article-title":"Hesperidin attenuates cisplatin-induced acute renal injury by decreasing oxidative stress, inflammation and DNA damage","volume":"20","author":"Sahu BD","year":"2013","journal-title":"Phytomed"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1179\/1351000212Y.0000000019","article-title":"Renal protective effect of hesperidin on gentamicin-induced acute nephrotoxicity in male Wistar albino rats","volume":"17","author":"Anandan R","year":"2012","journal-title":"Redox Rep"}],"container-title":["Revista Brasileira de Enfermagem"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/reben\/v71n4\/0034-7167-reben-71-04-1921.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,9,5]],"date-time":"2018-09-05T15:55:54Z","timestamp":1536162954000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0034-71672018000401921&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,8]]},"references-count":33,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,8]]}},"alternative-id":["S0034-71672018000401921"],"URL":"https:\/\/doi.org\/10.1590\/0034-7167-2017-0469","relation":{},"ISSN":["1984-0446","0034-7167"],"issn-type":[{"type":"electronic","value":"1984-0446"},{"type":"print","value":"0034-7167"}],"subject":[],"published":{"date-parts":[[2018,8]]}}}