{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,12]],"date-time":"2024-07-12T02:56:05Z","timestamp":1720752965468},"reference-count":31,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Enferm."],"abstract":"<jats:p>ABSTRACT Objective: To identify biomarkers for Parkinson\u2019s disease, cerebrospinal fluid, blood, saliva, and urine. Method: The studies were collected from the Cochrane, LILACS, PubMed, SCOPUS, WEB OF SCIENCE, OpenGrey, ProQuest and Google Scholar databases starting from May 3, 2016 and updated on March 20, 2017. Twenty-two studies were evaluated, by the Quality Assessment Tool for Diagnostic Accuracy Studies and Review Manager 5.3. Results: Evidence shows that serum antibodies can be used as highly specific and accurate biomarkers for the diagnosis of Parkinson\u2019s disease at the outset. Biomarkers in the cerebrospinal fluid are related to increased motor severity, postural instability, gait abnormality, and cognitive impairment. Conclusion: Serum and cerebrospinal antibodies can be used as diagnostic biomarkers at the onset of the disease.<\/jats:p>","DOI":"10.1590\/0034-7167-2017-0822","type":"journal-article","created":{"date-parts":[[2018,12,4]],"date-time":"2018-12-04T17:37:14Z","timestamp":1543945034000},"page":"3074-3083","source":"Crossref","is-referenced-by-count":1,"title":["Diagnostic validity of biomarkers in Parkinson\u2019s Disease: systematic review and meta-analysis"],"prefix":"10.1590","volume":"71","author":[{"given":"Maria Fernanda Baeta Neves Alonso da","family":"Costa","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Catarina, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emilene","family":"Reisdorfer","sequence":"additional","affiliation":[{"name":"Centre for Addiction and Mental Health, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvana 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