{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T22:32:16Z","timestamp":1780353136986,"version":"3.54.1"},"reference-count":48,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,2,1]],"date-time":"2019-02-01T00:00:00Z","timestamp":1548979200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Enferm."],"abstract":"<jats:p>ABSTRACT  Objective: To identify evidence about the effects of growth factor application on venous ulcer healing.  Method: Systematic review and meta-analysis, including Randomized Clinical Trials. Searches: Ovid MEDLINE, EMBASE, CINAHL, Cochrane CENTRAL, LILACS, Web of Science, Digital Library of Theses and Dissertations; Google Scholar and list of references.  Results: 802 participants were recruited from the 10 included studies: 472 in the intervention group (growth factors) and 330 as control. The relative risk for the complete healing outcome was 1.06 [95% CI 0.92-1.22], p = 0.41. Participants who received Platelet-Rich Plasma and Epidermal Growth Factor showed a slight tendency to achieve complete healing, but without statistical relevance (p &lt;0.05). Most of the studies were classified as moderate risk of bias.  Conclusion: The effect of the application of growth factors for complete healing in venous ulcers is not clear, and clinical trials with methodological quality are required for more accurate recommendations.<\/jats:p>","DOI":"10.1590\/0034-7167-2017-0865","type":"journal-article","created":{"date-parts":[[2019,3,26]],"date-time":"2019-03-26T21:45:28Z","timestamp":1553636728000},"page":"200-210","source":"Crossref","is-referenced-by-count":13,"title":["Treatment of venous ulcers with growth factors: systematic review and meta-analysis"],"prefix":"10.1590","volume":"72","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2261-5570","authenticated-orcid":false,"given":"Magali Rezende de","family":"Carvalho","sequence":"first","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5458-0456","authenticated-orcid":false,"given":"Isabelle Andrade","family":"Silveira","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7494-7457","authenticated-orcid":false,"given":"Beatriz Guitton Renaud Baptista de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,2]]},"reference":[{"issue":"265","key":"ref1","first-page":"265sr6","article-title":"Wound repair and regeneration: mechanisms, signaling, and translation","volume":"6","author":"Eming SA","year":"2014","journal-title":"SciTransl Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1159\/000339613","article-title":"Wound repair and regeneration","volume":"49","author":"Reinke JM","year":"2012","journal-title":"Eur Surg 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