{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T15:17:57Z","timestamp":1793114277450,"version":"4.5.0"},"reference-count":39,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rev. Bras. Enferm."],"abstract":"<jats:p>ABSTRACT  Objectives: to identify the scientific evidence about the clinical complications and manifestations of congenital syphilis and aspects related to its prevention.  Methods: integrative review after a search in the databases LILACS and MEDLINE, carried out in March 2018, using the descriptors \u201csyphilis, congenital\u201d, \u201ccomplications\u201d, and \u201csigns and symptoms\u201d, leading to the selection of 27 researches.  Results: the publications found were published from 1966 to 2017, and most of them were from Latin America and Africa. Negative outcomes, laboratory changes, and the clinical manifestations in congenital syphilis, whether early or delayed, were, respectively: low weight at birth, anemia, hepatosplenomegaly, and dental alterations. The lack of treatment of the pregnant women in the prenatal was the most common occasion in which the opportunity to prevent the complications of congenital syphilis was lost.  Conclusions: the scientific evidences analyzed showed serious complications of congenital syphilis that could be avoided if early opportunities of diagnosing and treating the pregnant women are not lost during the prenatal.<\/jats:p>","DOI":"10.1590\/0034-7167-2019-0318","type":"journal-article","created":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T08:04:51Z","timestamp":1626249891000},"source":"Crossref","is-referenced-by-count":21,"title":["Complications, clinical manifestations of congenital syphilis, and aspects related to its prevention: an integrative review"],"prefix":"10.1590","volume":"74","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4937-6397","authenticated-orcid":false,"given":"Ana F\u00e1tima Braga","family":"Rocha","sequence":"first","affiliation":[{"name":"Faculdade Terra Nordeste,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4156-5783","authenticated-orcid":false,"given":"Maria Alix Leite","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade de Fortaleza,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5109-9800","authenticated-orcid":false,"given":"Val\u00e9ria Lima de","family":"Barros","sequence":"additional","affiliation":[{"name":"Universidade Federal do Piau\u00ed,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8651-3880","authenticated-orcid":false,"given":"Camila F\u00e9lix","family":"Am\u00e9rico","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-0994","authenticated-orcid":false,"given":"Geraldo Bezerra da","family":"Silva J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade de Fortaleza,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"key":"ref1","series-title":"The Global elimination of congenital syphilis: rationale and strategy for action [Internet]","year":"2007"},{"key":"ref2","series-title":"Global guidance on criteria and processes for validation: elimination of mother-to-child transmission of HIV and syphilis [Internet]","year":"2014"},{"issue":"8","key":"ref3","first-page":"525","article-title":"Global burden of maternal and congenital syphilis in 2008 and 2012: a health systems modelling study","volume":"4","author":"Wijesooriya NS","year":"2016","journal-title":"Lancet"},{"key":"ref4","series-title":"Guia sobre Desenvolvimento Sustent\u00e1vel: 17 objetivos para transformar o nosso mundo [Internet]","year":"2016"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"217","DOI":"10.2471\/BLT.12.107623","article-title":"Untreated maternal syphilis and adverse outcomes of pregnancy: a systematic review and meta-analysis","volume":"91","author":"Gomez GB","year":"2013","journal-title":"Bull World Health Organ"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001396","article-title":"Global estimates of syphilis in pregnancy and associated adverse outcomes: analysis of multinational antenatal surveillance data","volume":"10","author":"Newman L","year":"2013","journal-title":"PLoS Med"},{"issue":"6","key":"ref7","article-title":"Incid\u00eancia de s\u00edfilis cong\u00eanita e fatores associados \u00e0 transmiss\u00e3o vertical da s\u00edfilis: dados do estudo Nascer no Brasil","volume":"32","author":"Domingues RMSM","year":"2016","journal-title":"Cad Sa\u00fade P\u00fablica"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1097\/OLQ.0b013e31827bd688","article-title":"Clinical features and follow-up of congenital syphilis","volume":"40","author":"Lago G","year":"2013","journal-title":"Sex Transm Dis"},{"key":"ref9","series-title":"Guidelines for the treatment of Treponema pallidum (syphilis) [Internet]","year":"2016"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/nur.4770100103","article-title":"Integrative reviews of nursing research","volume":"10","author":"Ganong LH","year":"1987","journal-title":"Res Nurs Health"},{"issue":"1","key":"ref11","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1097\/00006199-200501000-00008","article-title":"Combining evidence in nursing research: methods and implications","volume":"54","author":"Whittemore R","year":"2005","journal-title":"Nurs Res"},{"key":"ref12","series-title":"Evidence-based practice in nursing and health: a guide to best practice","author":"Melnyk BM","year":"2011"},{"issue":"1","key":"ref13","first-page":"17","article-title":"Analysis of congenital syphilis cases notification in a reference hospital of Niter\u00f3i, Rio de Janeiro State, from 2008 to 2015","volume":"29","author":"Souza LFM","year":"2017","journal-title":"DST J Bras Doen\u00e7as Sex Transm"},{"issue":"12","key":"ref14","article-title":"Underreporting of congenital syphilis as a cause of fetal and infant deaths in Northeastern Brazil","volume":"11","author":"Cardoso ARP","year":"2016","journal-title":"PLoS ONE"},{"issue":"4","key":"ref15","first-page":"727","article-title":"Adherence to the follow-up of the newborn exposed to syphilis and factors associated with loss to follow-up","volume":"19","author":"Feliz MC","year":"2016","journal-title":"Rev Bras Epidemiol"},{"key":"ref16","article-title":"Skin rash: a manifestation of early congenital syphilis","author":"Ferreira ST","year":"2016","journal-title":"BMJ Case Reports"},{"issue":"1","key":"ref17","first-page":"63","article-title":"Maternal and congenital syphilis, underreported and difficult to control","volume":"19","author":"Lafet\u00e1 KRG","year":"2016","journal-title":"Rev Bras Epidemiol"},{"key":"ref18","article-title":"Epidemic Profile of Maternal Syphilis in China in 2013","author":"Dou L","year":"2016","journal-title":"BioMed Research International"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/j.ijgo.2014.09.017","article-title":"Gestational syphilis and stillbirth in Latin America and the Caribbean","volume":"128","author":"Arnesen L","year":"2015","journal-title":"Int J Gynaecol Obstet."},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"426e1","DOI":"10.1016\/j.ajog.2014.05.049","article-title":"Progression of ultrasound findings of fetal syphilis after maternal treatment","volume":"211","author":"Rac MWF","year":"2014","journal-title":"Am J Obstet Gynecol."},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"333","DOI":"10.4103\/0970-4388.140969","article-title":"Early detection of congenital syphilis","volume":"32","author":"Chowdhary N","year":"2014","journal-title":"J Indian Soc Pedod Prev Dent"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"86","DOI":"10.4067\/S0370-41062014000100012","article-title":"S\u00edfilis cong\u00e9nita precoz: a prop\u00f3sito de 2 casos cl\u00ednicos","volume":"85","author":"Cavagnaro FSM","year":"2014","journal-title":"Rev Chile Pediatr."},{"issue":"5","key":"ref23","first-page":"558","article-title":"Congenital syphilis: presenting as septic shock alter the neonatal period","volume":"29","author":"Arriagada D","year":"2012","journal-title":"Rev Chile Infectol."},{"key":"ref24","first-page":"bcr1120115130","article-title":"Clinical aspects of congenital syphilis with Hutchinson's triad","author":"Pessoa L","year":"2011","journal-title":"BMJ Case Rep."},{"key":"ref25","series-title":"Int J Infect Dis","first-page":"e45","volume-title":"Maternal and congenital syphilis in Shanghai, China, 2002 to 2006","volume":"14","author":"Zhu L","year":"2010"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1007\/s12519-010-0028-z","article-title":"Congenital syphilis: still a serious, under-diagnosed threat for children in resource-poor countries","volume":"6","author":"Kr\u00fcger C","year":"2010","journal-title":"World J Pediatr."},{"issue":"4","key":"ref27","first-page":"307","article-title":"S\u00edfilis cong\u00e9nita: optimizando el diagn\u00f3stico en 191 neonatos de madres seropositivas","volume":"21","author":"Reyes JA","year":"2004","journal-title":"Rev Chile Infectol."},{"issue":"4","key":"ref28","first-page":"240","article-title":"S\u00edfilis cong\u00e9nita: presentaci\u00f3n de un caso y revisi\u00f3n de la literatura","volume":"64","author":"Pe\u00f1a A","year":"2001","journal-title":"Rev M\u00e9d Hosp Gen M\u00e9x [Internet]"},{"issue":"6","key":"ref29","first-page":"773","article-title":"Syphilis-associated perinatal and infant mortality in rural Malawi","volume":"71","author":"McDermott J","year":"1993","journal-title":"Bull World Health Organ [Internet]"},{"issue":"5","key":"ref30","first-page":"300","article-title":"Congenital syphilis in The Netherlands: diagnosis and clinical features","volume":"65","author":"Boot JM","year":"1989","journal-title":"Genitourin Med."},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"1393","DOI":"10.1136\/adc.63.11.1393","article-title":"Congenital syphilis in the newborn","volume":"63","author":"Chawla V","year":"1988","journal-title":"Arch Dis Child"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1136\/adc.60.12.1128","article-title":"Early congenital syphilis still occurs","volume":"60","author":"Ewing CI","year":"1985","journal-title":"Arch Dis Child"},{"issue":"2","key":"ref33","first-page":"103","article-title":"S\u00edndrome Nefr\u00f3tico Secundario a Lues Cong\u00e9nita","volume":"56","author":"Aguayo IT","year":"1985","journal-title":"Rev Chile Pediatr."},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1136\/adc.48.5.375","article-title":"Congenital syphilis and glomerulonephritis with evidence for immune pathogenesis","volume":"48","author":"Wiggelinkhuizen J","year":"1973","journal-title":"Arch Dis Child"},{"issue":"215","key":"ref35","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1136\/adc.41.215.87","article-title":"Thrombocytopenia and congenital syphilis in South African Bantu infants","volume":"41","author":"Freiman I","year":"1966","journal-title":"Arch Dis Child"},{"key":"ref36","series-title":"Protocolo Cl\u00ednico e Diretrizes Terap\u00eauticas para Preven\u00e7\u00e3o da Transmiss\u00e3o Vertical do HIV, S\u00edfilis e Hepatites Virais [Internet]","year":"2019"},{"issue":"Suppl 3","key":"ref37","doi-asserted-by":"crossref","first-page":"S9","DOI":"10.1186\/1471-2458-11-S3-S9","article-title":"Lives Saved Tool supplement detection and treatment of syphilis in pregnancy to reduce syphilis related stillbirths and neonatal mortality","volume":"11","author":"Blencowe H","year":"2011","journal-title":"BMC Public Health"},{"issue":"2","key":"ref38","first-page":"56","article-title":"Gesta\u00e7\u00f5es complicadas por s\u00edfilis materna e \u00f3bito fetal","volume":"34","author":"Nascimento MI","year":"2012","journal-title":"Rev Bras Ginecol Obstet"},{"issue":"3","key":"ref39","first-page":"376","article-title":"Late diagnosis of congenital syphilis: a recurring reality in woman and chil-dren health care in Brazil","volume":"36","author":"Andrade ALMB","year":"2018","journal-title":"Rev Paul Pediatr"}],"container-title":["Revista Brasileira de Enfermagem"],"original-title":[],"deposited":{"date-parts":[[2021,7,14]],"date-time":"2021-07-14T08:05:58Z","timestamp":1626249958000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0034-71672021000400300&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":39,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2021]]}},"alternative-id":["S0034-71672021000400300"],"URL":"https:\/\/doi.org\/10.1590\/0034-7167-2019-0318","relation":{},"ISSN":["1984-0446","0034-7167"],"issn-type":[{"value":"1984-0446","type":"electronic"},{"value":"0034-7167","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"e20190318"}}