{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T02:58:40Z","timestamp":1789700320489,"version":"4.0.1"},"reference-count":68,"publisher":"FapUNIFESP (SciELO)","issue":"8","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760150163","type":"journal-article","created":{"date-parts":[[2015,11,20]],"date-time":"2015-11-20T22:00:34Z","timestamp":1448056834000},"page":"981-988","source":"Crossref","is-referenced-by-count":15,"title":["Antiplasmodial activity of iron(II) and ruthenium(II) organometallic complexes against Plasmodium falciparum blood parasites"],"prefix":"10.1590","volume":"110","author":[{"given":"Nicolli Bellotti de","family":"Souza","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Caroline Campos","family":"Aguiar","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alane Cabral de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Brasil; Universidade Federal de Alagoas, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siden","family":"Top","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Pigeon","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, France; Ecole Nationale Sup\u00e9rieure de Chimie de Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G\u00e9rard","family":"Jaouen","sequence":"additional","affiliation":[{"name":"Sorbonne Universit\u00e9s, France; Ecole Nationale Sup\u00e9rieure de Chimie de Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marilia Oliveira Fonseca","family":"Goulart","sequence":"additional","affiliation":[{"name":"Universidade Federal de Alagoas, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antoniana Ursine","family":"Krettli","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2015,11,24]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"4677","DOI":"10.1039\/c3dt32740j","article-title":"The synthesis and antiparasitic activity of aryl and ferrocenyl-derived thiosemicarbazone ruthenium(II) - arene complexes","volume":"42","author":"Adams M","year":"2013","journal-title":"Dalton Trans"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1038\/sj.bjc.6600290","article-title":"In vitro and in vivo activity and cross resistance profiles of novel ruthenium(II) organometallic arene complexes in human ovarian cancer","volume":"86","author":"Aird RE","year":"2002","journal-title":"Br J Cancer"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1056\/NEJMoa1314981","article-title":"Spread of artemisinin resistance in Plasmodium falciparum malaria","volume":"371","author":"Ashley EA","year":"2014","journal-title":"N Engl J Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jinorgbio.2014.03.009","article-title":"Antiparasitic activities of novel ruthenium\/lapachol complexes","volume":"136","author":"Barbosa MI","year":"2014","journal-title":"J Inorg Biochem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"3046","DOI":"10.1039\/B303335J","article-title":"Synthesis and antiplasmodial activity in vitro of new ferrocene-chloroquine analogues","volume":"15","author":"Beagley P","year":"2003","journal-title":"Dalton Trans"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1078\/094471103322331458","article-title":"Cytotoxic activity of some lichen extracts on murine and human cancer cell lines","volume":"10","author":"B\u00e9zivin C","year":"2003","journal-title":"Phytomedicine"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2174\/1568012043354008","article-title":"Ferroquine: a new weapon in the fight against malaria","volume":"3","author":"Biot C","year":"2004","journal-title":"Antiinfect Agents Med Chem"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1039\/c2dt12247b","article-title":"The therapeutic potential of metal-based antimalarial agents: implications for the mechanism of action","volume":"41","author":"Biot C","year":"2012","journal-title":"Dalton Trans"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1039\/c2mt20063e","article-title":"Opening up the advantages of the ruthenocenic bioprobes of ferroquine: distribution and localization in Plasmodium falciparum-infected erythrocytes","volume":"4","author":"Biot C","year":"2012","journal-title":"Metallomics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"6434","DOI":"10.1016\/j.bmcl.2007.10.003","article-title":"Design, synthesis, and antimalarial activity of structural chimeras of thiosemicarbazone and ferroquine analogues","volume":"17","author":"Biot C","year":"2007","journal-title":"Bioorg Med Chem Lett"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0887-2333(88)90030-6","article-title":"Comparisons of two in vitro cytotoxicity assays: the neutral red (NR) and tetrazolium MTT tests","volume":"2","author":"Borenfreund E","year":"1987","journal-title":"Toxicol In Vitro"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.drup.2006.05.002","article-title":"DNA binding mode of ruthenium complexes and relationship to tumor cell toxicity","volume":"9","author":"Brabec V","year":"2006","journal-title":"Drug Resist Updat"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"6773","DOI":"10.1021\/jm8006678","article-title":"Emerging protein targets for anticancer metallodrugs: inhibition of thioredoxin reductase and cathepsin B by antitumor ruthenium(II)-arene compounds","volume":"51","author":"Casini A","year":"2008","journal-title":"J Med Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1039\/C3DT52070F","article-title":"Synthesis and antiproliferative activity of hydroxyferrocifen hybrids against triple-negative breast cancer cells","volume":"43","author":"C\u00e1zares-Marinero JJ","year":"2014","journal-title":"Dalton Trans"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"4793","DOI":"10.1021\/om400493k","article-title":"Di-and trinuclear ruthenium, rhodium, and iridium-functionalized pyridyl aromatic ethers: a new class of antiparasitic agents","volume":"32","author":"Chellan P","year":"2013","journal-title":"Organometallics"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1039\/C3DT52090K","article-title":"Synthesis and evaluation of new polynuclear organometallic Ru(II), Rh(III) and Ir(III) pyridyl ester complexes as in vitro antiparasitic and antitumor agents","volume":"43","author":"Chellan P","year":"2014","journal-title":"Dalton Trans"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"5392","DOI":"10.1073\/pnas.1218412110","article-title":"Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum","volume":"110","author":"Chugh M","year":"2013","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"8849","DOI":"10.1021\/jm5013165","article-title":"Evidence for targeting thioredoxin reductases with ferrocenyl quinone methides. A possible molecular basis for the antiproliferative effect of hydroxyferrocifens on cancer cells","volume":"57","author":"Citta A","year":"2014","journal-title":"J Med Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"5671","DOI":"10.1021\/om300737y","article-title":"Introduction to the organometallics in biology and medicine issue","volume":"31","author":"Coogan MP","year":"2012","journal-title":"Organometallics"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/S0378-8741(02)00005-3","article-title":"Antimalarial activity of medicinal plants used in traditional medicine in S. Tome and Principe islands","volume":"81","author":"de Madureira MC","year":"2002","journal-title":"J Ethnopharmacol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1002\/cmdc.201402219","article-title":"Molecular mechanism of action of 2-ferrocenyl-1,1-diphenylbut-1-ene on HL-60 leukemia cells","volume":"11","author":"de Oliveira AC","year":"2014","journal-title":"ChemMedChem"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"3778","DOI":"10.1016\/j.ejmech.2011.05.043","article-title":"Biological evaluation of twenty-eight ferrocenyl tetrasubstituted olefins: cancer cell growth inhibition, ROS production and hemolytic activity","volume":"46","author":"de Oliveira AC","year":"2011","journal-title":"Eur J Med Chem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1580","DOI":"10.1002\/anie.200503468","article-title":"Ruthenium half-sandwich complexes bound to protein kinase pim-1","volume":"45","author":"Debreczeni JE","year":"2006","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/0022-1759(86)90368-6","article-title":"Rapid colorimetric assay for cell growth and survival. Modifications to the tetrazolium dye procedure giving improved sensitivity and reliability","volume":"89","author":"Denizot F","year":"1986","journal-title":"J Immunol Methods"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1039\/C1CC16211J","article-title":"In situ nanochemical imaging of label-free drugs: a case study of antimalarials in Plasmodium falciparum-infected erythrocytes","volume":"48","author":"Dubar F","year":"2012","journal-title":"Chem Commun"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1021\/cb100322v","article-title":"The antimalarial ferroquine: role of the metal and intramolecular hydrogen bond in activity and resistance","volume":"6","author":"Dubar F","year":"2011","journal-title":"ACS Chem Biol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1016\/j.jorganchem.2010.09.015","article-title":"Evaluation of bactericidal and fungicidal activity of ferrocenyl or phenyl derivatives in the diphenyl butene series","volume":"69","author":"El Arbi M","year":"2011","journal-title":"J Organomet Chem"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1039\/b924677k","article-title":"Cysteine proteases as targets for metal-based drugs","volume":"2","author":"Fricker SP","year":"2010","journal-title":"Metallomics"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.ica.2012.05.028","article-title":"Perspectives on what ruthenium-based compounds could offer in the development of potential antiparasitic drugs","volume":"393","author":"Gambino D","year":"2012","journal-title":"Inorg Chim Acta"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1021\/jm100020w","article-title":"Organometallic anticancer compounds","volume":"54","author":"Gasser G","year":"2011","journal-title":"J Med Chem"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1039\/c2dt12083f","article-title":"Ruthenium(II) arene complexes with chelating chloroquine analogue ligands: synthesis, characterization and in vitro antimalarial activity","volume":"41","author":"Glans L","year":"2012","journal-title":"Dalton Trans"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"9045","DOI":"10.1039\/C4DT00463A","article-title":"Structural characterization and biological evaluation of a clioquinol-ruthenium complex with copper-independent antileukaemic activity","volume":"43","author":"Gobec M","year":"2014","journal-title":"Dalton Trans"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"2039","DOI":"10.1002\/cmdc.201000286","article-title":"Synthesis, cytotoxicity, and COMPARE analysis of ferrocene and [3]ferrocenophane tetrasubstituted olefin derivatives against human cancer cells","volume":"5","author":"G\u00f6rmen M","year":"2010","journal-title":"ChemMedChem"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1039\/c0md00026d","article-title":"Facile synthesis and strong antiproliferative activity of disubstituted diphenylmethylidenyl-[3]ferrocenophanes on breast and prostate cancer cell lines","volume":"1","author":"G\u00f6rmen M","year":"2010","journal-title":"MedChemCommun"},{"key":"ref35","article-title":"Failure of supervised chloroquine and primaquine regimen for the treatment of Plasmodium vivax in the Peruvian Amazon","author":"Graf PC","year":"2012","journal-title":"Malar Res Treat"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"9124","DOI":"10.1002\/anie.200903768","article-title":"Ferrocenyl quinone methides as strong antiproliferative agents: formation by metabolic and chemical oxidation of ferrocenyl phenols","volume":"48","author":"Hamels D","year":"2009","journal-title":"Angew Chem Int Ed Engl"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1716","DOI":"10.1016\/j.jorganchem.2007.12.011","article-title":"Ferrocenyl compounds possessing protected phenol and thiophenol groups: synthesis, X-ray structure, and in vitro biological effects against breast cancer","volume":"693","author":"Heilmann JB","year":"2008","journal-title":"J Organomet Chem"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1517\/13543784.2015.1000483","article-title":"Antimalarial compounds in Phase II clinical development","volume":"24","author":"Held J","year":"2015","journal-title":"Expert Opin Investig Drugs"},{"key":"ref39","article-title":"Ferroquine and artesunate in African adults and children with Plasmodium falciparum malaria: a Phase 2, multicentre, randomised, double-blind, dose-ranging, non-inferiority study","author":"Held J","year":"2015","journal-title":"Lancet Infect Dis"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"5073","DOI":"10.1039\/b705030e","article-title":"The influence of phenolic hydroxy substitution on the electron transfer and anti-cancer properties of compounds based on the 2-ferrocenyl-1-phenyl-but-1-ene motif","volume":"43","author":"Hillard EA","year":"2007","journal-title":"Dalton Trans"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"40180","DOI":"10.1074\/jbc.M007633200","article-title":"The thioredoxin system of the malaria parasite Plasmodium falciparum glutathione reduction revisited","volume":"275","author":"Kanzok SM","year":"2000","journal-title":"J Biol Chem"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"418","DOI":"10.2307\/3280287","article-title":"Sychronization of Plasmodium falciparum erythrocytic stages in culture","volume":"65","author":"Lambros C","year":"1979","journal-title":"J Parasitol"},{"key":"ref43","first-page":"4217","article-title":"Synthesis, characterization, and biological properties of osmium-based tamoxifen derivatives-comparison with their homologues in the iron and ruthenium series","volume":"25","author":"Lee HZS","year":"2015","journal-title":"Eur J Inorg Chem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4940","DOI":"10.1021\/om500225k","article-title":"Oxidative sequence of a ruthenocene-based anticancer drug candidate in a basic environment","volume":"33","author":"Lee HZS","year":"2014","journal-title":"Organometallics"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1128\/AAC.02279-12","article-title":"Plasmodium vivax chloroquine resistance and anemia in the western Brazilian Amazon","volume":"58","author":"Marques MM","year":"2014","journal-title":"Antimicrob Agents Chemother"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"3867","DOI":"10.1021\/jm300070h","article-title":"Searching for new chemotherapies for tropical diseases: ruthenium-clotrimazole complexes display high in vitro activity against Leishmania major and Trypanosoma cruzi and low toxicity toward normal mammalian cells","volume":"55","author":"Mart\u00ednez A","year":"2012","journal-title":"J Med Chem"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1007\/s00775-009-0498-4","article-title":"The antimalarial activity of Ru-chloroquine complexes against resistant Plasmodium falciparum is related to lipophilicity, basicity, and heme aggregation inhibition ability near water\/n-octanol interfaces","volume":"14","author":"Mart\u00ednez A","year":"2009","journal-title":"J Biol Inorg Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.1021\/jm00118a010","article-title":"A comprehensive method for determining hydrophobicity constants by reversed-phase high-performance liquid chromatography","volume":"31","author":"Minick DJ","year":"1988","journal-title":"J Med Chem"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/ng.2624","article-title":"Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia","volume":"45","author":"Miotto O","year":"2013","journal-title":"Nat Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"716","DOI":"10.2533\/chimia.2007.716","article-title":"Ferrocifens and ferrocifenols as new potential weapons against breast cancer","volume":"61","author":"Nguyen A","year":"2007","journal-title":"Chimia"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0014-4894(03)00051-1","article-title":"Plasmodium falciparum: effect of antimalarial drugs on the production and secretion characteristics of histidine-rich protein II","volume":"102","author":"Noedl H","year":"2002","journal-title":"Exp Parasitol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1016\/0014-4894(88)90082-3","article-title":"Plasmodium falciparum: induction of resistance to mefloquine in cloned strains by continuous drug exposure in vitro","volume":"67","author":"Oduola AM","year":"1988","journal-title":"Exp Parasitol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1021\/jm049268h","article-title":"Selective estrogen receptor modulators in the ruthenocene series. Synthesis and biological behaviour","volume":"48","author":"Pigeon P","year":"2005","journal-title":"J Med Chem"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1007\/978-3-642-13185-1_2","article-title":"Activation mechanisms for organometallic anticancer complexes","volume":"32","author":"Pizarro AM","year":"2010","journal-title":"Top Organomet Chem"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.1021\/jm00174a009","article-title":"11.beta.-methoxy-, 11.beta.-ethyl, and 17.alpha.-ethynyl-substituted 16.alpha.-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity","volume":"33","author":"Pomper MG","year":"1990","journal-title":"J Med Chem"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1021\/ic802220w","article-title":"Synthesis, characterization, and in vitro antimalarial and antitumor activity of new ruthenium(II) complexes of chloroquine","volume":"48","author":"Rajapakse CS","year":"2009","journal-title":"Inorg Chem"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/S0140-6736(78)90365-3","article-title":"Drug sensitivity of Plasmodium falciparum. An in vitro microtechnique","volume":"1","author":"Rieckmann K","year":"1978","journal-title":"Lancet"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1070","DOI":"10.1021\/jm00351a013","article-title":"1,1,2-triphenylbut-1-enes: relationship between structure, estradiol receptor affinity, and mammary tumor inhibiting properties","volume":"25","author":"Schneider MR","year":"1982","journal-title":"J Med Chem"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ddr.20349","article-title":"Antiparasitic and immunomodulatory activities of 1,1-bis(4-hydroxyphenyl)-2-phenyl-but-1-ene and its protected and free 2-ferrocenyl derivatives","volume":"71","author":"Soares MBP","year":"2010","journal-title":"Drug Develop Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"2156","DOI":"10.1021\/ic802105b","article-title":"One-electron oxidation of ruthenocene: reactions of the ruthenocenium ion in gentle electrolyte media","volume":"48","author":"Swarts JC","year":"2009","journal-title":"Inorg Chem"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"7537","DOI":"10.1039\/c2dt30700f","article-title":"Ferrocenyl catechols: synthesis, oxidation chemistry and anti-proliferative effects on MDA-MB-231 breast cancer cells","volume":"41","author":"Tan YL","year":"2012","journal-title":"Dalton Trans"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1021\/ic1019372","article-title":"Synthetic and mechanistic pathways of cis and trans-hydroxytamoxifen drug derivatives reacting with Cp* Rh complexes that involve \u03b71-N, \u03b72-N, O, \u03b71-O, and \u03b76 bonding modes, via a novel N-\u03c0 rearrangement; relative binding affinities and computer docking studies of cis and trans-\u03b76-Cp* Rh-hydroxytamoxifen complexes at the estrogen, ER\u03b1 and ER\u03b2 receptors, and growth inhibition to breast cancer cells","volume":"50","author":"Top S","year":"2011","journal-title":"Inorg Chem"},{"issue":"643-644","key":"ref63","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/S0022-328X(01)01271-2","article-title":"The first titanocenyl dichloride moiety vectorised by a selective estrogen receptor modulator (SERM). Synthesis and preliminary bio-chemical behaviour","author":"Top S","year":"2002","journal-title":"J Organomet Chem"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"5223","DOI":"10.1002\/chem.200305024","article-title":"Synthesis, biochemical properties and molecular modeling studies of organometallic specific estrogen receptor modulators (SERMs), the ferrocifens and hydroxyferrocifens: evidence for an antiproliferative effect of hydroxyferrocifens on both hormone-dependent and hormone-independent breast cancer cell lines","volume":"9","author":"Top S","year":"2003","journal-title":"Chemistry"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1126\/science.781840","article-title":"Human malaria parasites in continuous culture","volume":"193","author":"Trager W","year":"1976","journal-title":"Science"},{"key":"ref66","first-page":"109","article-title":"Bridged ferrocenes. XII. Synthesis of [3]ferrocenophan-1-one from ferrocene by a novel one-step annelation reaction","volume":"46","author":"Turbitt TD","year":"1972","journal-title":"J Organomet Chem"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1442","DOI":"10.1021\/cb4000844","article-title":"Analysis of the mechanism of action of potent antibacterial heterotri-organometallic compounds: a structurally new class of antibiotics","volume":"8","author":"Wenzel M","year":"2013","journal-title":"ACS Chem Biol"},{"key":"ref68","series-title":"World malaria report 2014","year":"2014"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v110n8\/0074-0276-mioc-0074-02760150163.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,31]],"date-time":"2025-05-31T13:21:21Z","timestamp":1748697681000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762015000800981&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,11,24]]},"references-count":68,"journal-issue":{"issue":"8","published-online":{"date-parts":[[2015,12]]}},"alternative-id":["S0074-02762015000800981"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760150163","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2015,11,24]]}}}