{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:42:12Z","timestamp":1790638932188,"version":"4.1.0"},"reference-count":89,"publisher":"FapUNIFESP (SciELO)","issue":"11","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"published-print":{"date-parts":[[2017,11]]},"DOI":"10.1590\/0074-02760170109","type":"journal-article","created":{"date-parts":[[2017,10,30]],"date-time":"2017-10-30T19:42:26Z","timestamp":1509392546000},"page":"733-740","source":"Crossref","is-referenced-by-count":23,"title":["Cytotoxic activity in cutaneous leishmaniasis"],"prefix":"10.1590","volume":"112","author":[{"given":"Ta\u00eds M","family":"Campos","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia, Brasil; Universidade Federal da Bahia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R\u00fabia","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Brasil; Universidade Federal da Bahia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Passos","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Brasil; Houston Methodist Research Institute, United States"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas P","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Brasil; Universidade Federal da Bahia, Brasil; Instituto Nacional de Ci\u00eancias e Tecnologia-Doen\u00e7as Tropicais, Brasil; Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/j.molcel.2011.07.037","article-title":"Granzyme B-dependent proteolysis acts as a switch to enhance the proinflammatory activity of IL-1alpha","volume":"44","author":"Afonina IS","year":"2011","journal-title":"Mol Cell."},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.imlet.2005.06.004","article-title":"Activated inflammatory T cells correlate with lesion size in human cutaneous leishmaniasis","volume":"101","author":"Antonelli LR","year":"2005","journal-title":"Immunol Lett."},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1016\/j.celrep.2014.06.012","article-title":"Elucidating sources and roles of granzymes A and B during bacterial infection and sepsis","volume":"8","author":"Arias MA","year":"2014","journal-title":"Cell Rep."},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"6734","DOI":"10.1128\/IAI.70.12.6734-6740.2002","article-title":"Up-regulation of Th1-type responses in mucosal leishmaniasis patients","volume":"70","author":"Bacellar O","year":"2002","journal-title":"Infect Immun."},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1084\/jem.20051474","article-title":"Natural killer cell behavior in lymph nodes revealed by static and real-time imaging","volume":"203","author":"Bajenoff M","year":"2006","journal-title":"J Exp Med."},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"587","DOI":"10.4269\/ajtmh.1992.47.587","article-title":"Lymphadenopathy associated with Leishmania braziliensis cutaneous infection","volume":"47","author":"Barral A","year":"1992","journal-title":"Am J Trop Med Hyg."},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"256","DOI":"10.4269\/ajtmh.1995.53.256","article-title":"Lymphadenopathy as the first sign of human cutaneous infection by Leishmania braziliensis","volume":"53","author":"Barral A","year":"1995","journal-title":"Am J Trop Med Hyg."},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1111\/j.1365-3024.1995.tb00962.x","article-title":"Cytotoxicity in human mucosal and cutaneous leishmaniasis","volume":"17","author":"Barral Netto M","year":"1995","journal-title":"Parasite Immunol."},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1590\/S0100-879X1998000100021","article-title":"Human_leishmaniasis\/cytokines.bahia.br","volume":"31","author":"Barral Netto M","year":"1998","journal-title":"Braz J Med Biol Res."},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0166-6851(03)00160-9","article-title":"Leishmania lipophosphoglycan (LPG) activates NK cells through toll-like receptor-2","volume":"130","author":"Becker I","year":"2003","journal-title":"Mol Biochem Parasitol"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"3992","DOI":"10.4049\/jimmunol.168.8.3992","article-title":"CD8+ T cells are required for primary immunity in C57BL\/6 mice following low-dose, intradermal challenge with Leishmania major","volume":"168","author":"Belkaid Y","year":"2002","journal-title":"J Immunol."},{"issue":"1-2","key":"ref12","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/S0022-1759(03)00265-5","article-title":"Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation","volume":"281","author":"Betts MR","year":"2003","journal-title":"J Immunol Methods"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003282","article-title":"Matrix metalloproteinase 9 production by monocytes is enhanced by TNF and participates in the pathology of human cutaneous leishmaniasis","volume":"8","author":"Campos TM","year":"2014","journal-title":"PLoS Negl Trop Dis."},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1128\/IAI.02404-14","article-title":"Protective and pathological functions of CD8+ T Cells in Leishmania braziliensis infection","volume":"83","author":"Cardoso TM","year":"2015","journal-title":"Infect Immun."},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1111\/j.1365-3024.2007.00940.x","article-title":"Differential immune regulation of activated T cells between cutaneous and mucosal leishmaniasis as a model for pathogenesis","volume":"29","author":"Carvalho LP","year":"2007","journal-title":"Parasite Immunol."},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.humimm.2009.01.007","article-title":"Th1\/Th2 immune responses are associated with active cutaneous leishmaniasis and clinical cure is associated with strong interferon-gamma production","volume":"70","author":"Castellano LR","year":"2009","journal-title":"Hum Immunol."},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1016\/j.actatropica.2008.03.006","article-title":"In vitro evidence for metallopeptidase participation in hepatocyte damage induced by Leishmania chagasi-infected macrophages","volume":"106","author":"Costa JD","year":"2008","journal-title":"Acta Trop."},{"issue":"7","key":"ref18","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.4049\/jimmunol.1500855","article-title":"Lymphocytic choriomeningitis virus expands a population of NKG2D+CD8+ T cells that exacerbates disease in mice coinfected with Leishmania major","volume":"195","author":"Crosby EJ","year":"2015","journal-title":"J Immunol."},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003970","article-title":"Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection","volume":"10","author":"Crosby EJ","year":"2014","journal-title":"PLoS Pathog."},{"issue":"2","key":"ref20","first-page":"251","article-title":"T-cell-mediated immune responses in patients with cutaneous or mucosal leishmaniasis: long-term evaluation after therapy","volume":"9","author":"Da-Cruz AM","year":"2002","journal-title":"Clin Diagn Lab Immunol."},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"2614","DOI":"10.1128\/IAI.62.6.2614-2618.1994","article-title":"Leishmania-reactive CD4+ and CD8+ T cells associated with cure of human cutaneous leishmaniasis","volume":"62","author":"Da-Cruz AM","year":"1994","journal-title":"Infect Immun."},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1590\/0037-8682-0174-2013","article-title":"CD8+ T cells in situ in different clinical forms of human cutaneous leishmaniasis","volume":"46","author":"Dantas ML","year":"2013","journal-title":"Rev Soc Bras Med Trop."},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1590\/S0037-86822002000100002","article-title":"Evaluation of IFN-gamma and TNF-alpha as immunological markers of clinical outcome in cutaneous leishmaniasis","volume":"35","author":"D'Oliveira Jr A","year":"2002","journal-title":"Rev Soc Bras Med Trop."},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003601","article-title":"Exposure to Leishmania braziliensis triggers neutrophil activation and apoptosis","volume":"9","author":"Falc\u00e3o SA","year":"2015","journal-title":"PLoS Negl Trop Dis."},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"7853","DOI":"10.1128\/IAI.73.12.7853-7859.2005","article-title":"Decreased in situ expression of interleukin-10 receptor is correlated with the exacerbated inflammatory and cytotoxic responses observed in mucosal leishmaniasis","volume":"73","author":"Faria DR","year":"2005","journal-title":"Infect Immun."},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/j.1365-3024.2009.01125.x","article-title":"Recruitment of CD8(+) T cells expressing granzyme A is associated with lesion progression in human cutaneous leishmaniasis","volume":"31","author":"Faria DR","year":"2009","journal-title":"Parasite Immunol."},{"issue":"15","key":"ref27","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1186\/s12879-015-0799-x","article-title":"Apoptosis and frequency of total and effector CD8+ T lymphocytes from cutaneous leishmaniasis patients during antimonial therapy","volume":"19","author":"Ferraz R","year":"2015","journal-title":"BMC Infect Dis."},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1186\/s13071-017-2152-2","article-title":"CD3+CD4negCD8neg (double negative) T lymphocytes and NKT cells as the main cytotoxic-related-CD107a+ cells in lesions of cutaneous leishmaniasis caused by Leishmania (Viannia) braziliensis","volume":"10","author":"Ferraz R","year":"2017","journal-title":"Parasit Vectors"},{"issue":"11","key":"ref29","doi-asserted-by":"crossref","first-page":"E54","DOI":"10.1086\/340261","article-title":"Epidemiologic and immunologic findings for the subclinical form of Leishmania braziliensis infection","volume":"34","author":"Follador I","year":"2002","journal-title":"Clin Infect Dis."},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1111\/j.1365-3083.2005.01707.x","article-title":"Mucosal leishmaniasis patients display an activated inflammatory T-cell phenotype associated with a nonbalanced monocyte population","volume":"63","author":"Gaze ST","year":"2006","journal-title":"Scand J Immunol."},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1002\/(SICI)1521-4141(199802)28:02<687::AID-IMMU687>3.0.CO;2-N","article-title":"Dendritic cells, but not macrophages, produce IL-12 immediately following Leishmania donovani infection","volume":"28","author":"Gorak PM","year":"1998","journal-title":"Eur J Immunol."},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1016\/j.molmed.2012.09.009","article-title":"Granzyme B in injury, inflammation, and repair","volume":"18","author":"Hiebert PR","year":"2012","journal-title":"Trends Mol Med."},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"1819","DOI":"10.1084\/jem.169.5.1819","article-title":"Elimination of CD4+ suppressor T cells from susceptible BALB\/c mice releases CD8+ T lymphocytes to mediate protective immunity against Leishmania","volume":"169","author":"Hill JO","year":"1989","journal-title":"J Exp Med."},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1189\/jlb.0909608","article-title":"The battlefield of perforin\/granzyme cell death pathways","volume":"87","author":"Hoves S","year":"2010","journal-title":"J Leukoc Biol."},{"issue":"8","key":"ref35","doi-asserted-by":"crossref","first-page":"3968","DOI":"10.1128\/IAI.66.8.3968-3970.1998","article-title":"Effective and long-lasting immunity against the parasite Leishmania major in CD8-deficient mice","volume":"66","author":"Huber M","year":"1998","journal-title":"Infect Immun."},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.exppara.2010.05.008","article-title":"Regulation of CD8+ T cell responses to infection with parasitic protozoa","volume":"126","author":"Jordan KA","year":"2010","journal-title":"Exp Parasitol"},{"issue":"8","key":"ref37","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1038\/nrmicro2608","article-title":"Leishmaniasis: complexity at the host-pathogen interface","volume":"9","author":"Kaye P","year":"2011","journal-title":"Nat Rev Microbiol"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1172\/JCI114649","article-title":"Induction of antigen-specific human cytotoxic T cells by Toxoplasma gondii","volume":"85","author":"Khan IA","year":"1990","journal-title":"J Clin Invest."},{"key":"ref39","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1146\/annurev.immunol.23.021704.115526","article-title":"NK cell recognition","volume":"23","author":"Lanier LL","year":"2005","journal-title":"Annu Rev Immunol."},{"issue":"9","key":"ref40","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1002\/eji.1830230928","article-title":"Natural killer cells participate in the early defense against Leishmania major infection in mice","volume":"23","author":"Laskay T","year":"1993","journal-title":"Eur J Immunol."},{"issue":"3","key":"ref41","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1590\/S0100-879X1999000300012","article-title":"The role of natural killer cells in the early period of infection in murine cutaneous leishmaniasis","volume":"32","author":"Laurenti MD","year":"1999","journal-title":"Braz J Med Biol Res."},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1084\/jem.20030795","article-title":"MHC class II expression restricted to CD8alpha+ and CD11b+ dendritic cells is sufficient for control of Leishmania major","volume":"199","author":"Lemos MP","year":"2004","journal-title":"J Exp Med."},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/j.1365-2249.2008.03687.x","article-title":"Leishmania surface protein gp63 binds directly to human natural killer cells and inhibits proliferation","volume":"153","author":"Lieke T","year":"2008","journal-title":"Clin Exp Immunol."},{"issue":"14","key":"ref44","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1017\/S0031182011001363","article-title":"The interplay between Leishmania promastigotes and human Natural Killer cells in vitro leads to direct lysis of Leishmania by NK cells and modulation of NK cell activity by Leishmania promastigotes","volume":"138","author":"Lieke T","year":"2011","journal-title":"Parasitology"},{"issue":"12","key":"ref45","doi-asserted-by":"crossref","first-page":"3424","DOI":"10.1002\/eji.200737182","article-title":"TLR9 signaling is essential for the innate NK cell response in murine cutaneous leishmaniasis","volume":"37","author":"Liese J","year":"2007","journal-title":"Eur J Immunol."},{"issue":"5","key":"ref46","first-page":"449","article-title":"Evidence of in situ cytotoxicity in American cutaneous leishmaniasis","volume":"12","author":"Machado P","year":"2002","journal-title":"Eur J Dermatol."},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1365-2249.2010.04285.x","article-title":"Therapeutic failure in American cutaneous leishmaniasis is associated with gelatinase activity and cytokine expression","volume":"163","author":"Maretti-Mira AC","year":"2011","journal-title":"Clin Exp Immunol."},{"issue":"2-3","key":"ref48","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.actatropica.2011.05.009","article-title":"MMP-9 activity is induced by Leishmania braziliensis infection and correlates with mucosal leishmaniasis","volume":"119","author":"Maretti-Mira AC","year":"2011","journal-title":"Acta Trop."},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/j.immuni.2008.08.014","article-title":"Human and mouse granzyme A induce a proinflammatory cytokine response","volume":"29","author":"Metkar SS","year":"2008","journal-title":"Immunity"},{"issue":"1","key":"ref50","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1128\/IAI.64.1.176-181.1996","article-title":"Human CD4+ and CD8+ T lymphocytes are both cytotoxic to Toxoplasma gondii-infected cells","volume":"64","author":"Montoya JG","year":"1996","journal-title":"Infect Immun."},{"issue":"6","key":"ref51","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1093\/intimm\/3.6.587","article-title":"Establishment of resistance to Leishmania major infection in susceptible BALB\/c mice requires parasite-specific CD8+ T cells","volume":"3","author":"Muller I","year":"1991","journal-title":"Int Immunol."},{"issue":"1-2","key":"ref52","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s004300100084","article-title":"Chemokines, natural killer cells and granulocytes in the early course of Leishmania major infection in mice","volume":"190","author":"Muller K","year":"2001","journal-title":"Med Microbiol Immunol."},{"key":"ref53","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/636039","article-title":"Involvement of different CD4(+) T cell subsets producing granzyme B in the immune response to Leishmania major antigens","volume":"2014","author":"Naouar I","year":"2014","journal-title":"Mediators Inflamm"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1006196","article-title":"CD8+ T cell cytotoxicity mediates pathology in the skin by inflammasome activation and IL-1beta production","volume":"13","author":"Novais FO","year":"2017","journal-title":"PLoS Pathog."},{"issue":"7","key":"ref55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003504","article-title":"Cytotoxic T cells mediate pathology and metastasis in cutaneous leishmaniasis","volume":"9","author":"Novais FO","year":"2013","journal-title":"PLoS Pathog."},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/jid.2014.305","article-title":"Genomic profiling of human Leishmania braziliensis lesions identifies transcriptional modules associated with cutaneous immunopathology","volume":"135","author":"Novais FO","year":"2015","journal-title":"J Invest Dermatol."},{"issue":"12","key":"ref57","doi-asserted-by":"crossref","first-page":"8088","DOI":"10.4049\/jimmunol.0803720","article-title":"Neutrophils and macrophages cooperate in host resistance against Leishmania braziliensis infection","volume":"183","author":"Novais FO","year":"2009","journal-title":"J Immunol."},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.jdermsci.2010.05.004","article-title":"Granzyme B is a novel interleukin-18 converting enzyme","volume":"59","author":"Omoto Y","year":"2010","journal-title":"J Dermatol Sci."},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/0165-2478(93)90126-M","article-title":"Course of Leishmania infection in beta 2-microglobulin-deficient mice","volume":"37","author":"Overath P","year":"1993","journal-title":"Immunol Lett."},{"issue":"5891","key":"ref60","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1126\/science.1159194","article-title":"In vivo imaging reveals an essential role for neutrophils in leishmaniasis transmitted by sand flies","volume":"321","author":"Peters NC","year":"2008","journal-title":"Science"},{"issue":"3","key":"ref61","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.coi.2007.04.011","article-title":"Delivering the kiss of death: progress on understanding how perforin works","volume":"19","author":"Pipkin ME","year":"2007","journal-title":"Curr Opin Immunol."},{"issue":"4","key":"ref62","doi-asserted-by":"crossref","first-page":"1390","DOI":"10.1172\/JCI116341","article-title":"Cytokine patterns in the pathogenesis of human leishmaniasis","volume":"91","author":"Pirmez C","year":"1993","journal-title":"J Clin Invest."},{"issue":"10","key":"ref63","doi-asserted-by":"crossref","first-page":"4330","DOI":"10.1128\/IAI.64.10.4330-4338.1996","article-title":"CD4-mediated and CD8-mediated cytotoxic and proliferative immune responses to Toxoplasma gondii in seropositive humans","volume":"64","author":"Purner MB","year":"1996","journal-title":"Infect Immun."},{"issue":"1","key":"ref64","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1590\/S0100-879X1998000100020","article-title":"Cytokine profile and pathology in human leishmaniasis","volume":"31","author":"Ribeiro-de-Jesus A","year":"1998","journal-title":"Braz J Med Biol Res."},{"issue":"6","key":"ref65","doi-asserted-by":"crossref","first-page":"3988","DOI":"10.4049\/jimmunol.179.6.3988","article-title":"Neutrophils activate macrophages for intracellular killing of Leishmania major through recruitment of TLR4 by neutrophil elastase","volume":"179","author":"Ribeiro-Gomes FL","year":"2007","journal-title":"J Immunol."},{"issue":"7","key":"ref66","doi-asserted-by":"crossref","first-page":"4454","DOI":"10.4049\/jimmunol.172.7.4454","article-title":"Macrophage interactions with neutrophils regulate Leishmania major infection","volume":"172","author":"Ribeiro-Gomes FL","year":"2004","journal-title":"J Immunol."},{"issue":"2","key":"ref67","article-title":"Efficient capture of infected neutrophils by dendritic cells in the skin inhibits the early anti-leishmania response","volume":"8","author":"Ribeiro-Gomes FL","year":"2012","journal-title":"PLoS Pathog."},{"issue":"12","key":"ref68","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1111\/j.1365-3024.2007.00991.x","article-title":"CD8 cytotoxic T cells in cutaneous leishmaniasis","volume":"29","author":"Ruiz JH","year":"2007","journal-title":"Parasite Immunol."},{"issue":"3","key":"ref69","doi-asserted-by":"crossref","first-page":"645","DOI":"10.4269\/ajtmh.16-0539","article-title":"Characterization of the histopathologic features in patients in the early and late phases of cutaneous leishmaniasis","volume":"96","author":"Saldanha MG","year":"2017","journal-title":"Am J Trop Med Hyg."},{"issue":"2","key":"ref70","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1038\/jid.2014.396","article-title":"Proteome profiling of human cutaneous leishmaniasis lesion","volume":"135","author":"Santos C","year":"2015","journal-title":"J Invest Dermatol."},{"issue":"6","key":"ref71","first-page":"1533","article-title":"CD8(+) granzyme B(+)-mediated tissue injury vs","volume":"133","author":"Santos CS","year":"2013","journal-title":"CD4(+)IFNgamma(+)-mediated parasite killing in human cutaneous leishmaniasis. J Invest Dermatol."},{"issue":"11","key":"ref72","doi-asserted-by":"crossref","first-page":"6747","DOI":"10.4049\/jimmunol.162.11.6747","article-title":"Mice lacking NK cells develop an efficient Th1 response and control cutaneous Leishmania major infection","volume":"162","author":"Satoskar AR","year":"1999","journal-title":"J Immunol."},{"key":"ref73","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1034\/j.1600-065X.2000.17706.x","article-title":"The neutrophil as a cellular source of chemokines","volume":"177","author":"Scapini P","year":"2000","journal-title":"Immunol Rev."},{"issue":"2","key":"ref74","doi-asserted-by":"crossref","first-page":"567","DOI":"10.1084\/jem.178.2.567","article-title":"Natural killer cells are a source of interferon gamma that drives differentiation of CD4+ T cell subsets and induces early resistance to Leishmania major in mice","volume":"178","author":"Scharton TM","year":"1993","journal-title":"J Exp Med."},{"issue":"6","key":"ref75","doi-asserted-by":"crossref","first-page":"871","DOI":"10.3201\/eid1506.080406","article-title":"Geographic clustering of leishmaniasis in northeastern Brazil","volume":"15","author":"Schriefer A","year":"2009","journal-title":"Emerg Infect Dis."},{"issue":"5","key":"ref76","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1084\/jem.168.5.1675","article-title":"Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens","volume":"168","author":"Scott P","year":"1988","journal-title":"J Exp Med."},{"issue":"1","key":"ref77","first-page":"159","article-title":"Extracellular activities of human granzymes. I. Granzyme A induces IL6 and IL8 production in fibroblast and epithelial cell lines","volume":"171","author":"Sower LE","year":"1996","journal-title":"Cell Immunol."},{"issue":"1","key":"ref78","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1128\/IAI.00338-10","article-title":"Leukocytes infiltrate the skin and draining lymph nodes in response to the protozoan Leishmania infantum chagasi","volume":"79","author":"Thalhofer CJ","year":"2011","journal-title":"Infect Immun."},{"issue":"8","key":"ref79","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/ni.2050","article-title":"Perforin pores in the endosomal membrane trigger the release of endocytosed granzyme B into the cytosol of target cells","volume":"12","author":"Thiery J","year":"2011","journal-title":"Nat Immunol."},{"issue":"10","key":"ref80","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1002\/eji.1830171007","article-title":"Involvement of specific Lyt-2+ T cells in the immunological control of experimentally induced murine cutaneous leishmaniasis","volume":"17","author":"Titus RG","year":"1987","journal-title":"Eur J Immunol."},{"issue":"11-12","key":"ref81","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1016\/j.mod.2008.07.005","article-title":"Three matrix metalloproteinases are required in vivo for macrophage migration during embryonic development","volume":"125","author":"Tomlinson ML","year":"2008","journal-title":"Mech Dev."},{"issue":"10","key":"ref82","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/nri911","article-title":"Functional significance of the perforin\/granzyme cell death pathway","volume":"2","author":"Trapani JA","year":"2002","journal-title":"Nat Rev Immunol."},{"issue":"12","key":"ref83","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2001-2-12-reviews3014","article-title":"Granzymes: a family of lymphocyte granule serine proteases","volume":"2","author":"Trapani JA","year":"2001","journal-title":"Genome Biol."},{"issue":"4","key":"ref84","doi-asserted-by":"crossref","first-page":"574","DOI":"10.4269\/ajtmh.2009.80.574","article-title":"Association of treatment of American cutaneous leishmaniasis prior to ulcer development with high rate of failure in northeastern Brazil","volume":"80","author":"Unger A","year":"2009","journal-title":"Am J Trop Med Hyg."},{"issue":"11","key":"ref85","doi-asserted-by":"crossref","first-page":"1559","DOI":"10.1084\/jem.20040172","article-title":"Low dose Leishmania major promotes a transient T helper cell type 2 response that is down-regulated by interferon gamma-producing CD8+ T cells","volume":"199","author":"Uzonna JE","year":"2004","journal-title":"J Exp Med."},{"issue":"9","key":"ref86","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1084\/jem.188.9.1651","article-title":"Interferon gamma derived from CD4(+) T cells is sufficient to mediate T helper cell type 1 development","volume":"188","author":"Wakil AE","year":"1998","journal-title":"J Exp Med."},{"issue":"4","key":"ref87","doi-asserted-by":"crossref","first-page":"2077","DOI":"10.4049\/jimmunol.151.4.2077","article-title":"Targeted activation of CD8 cells and infection of beta 2-microglobulin-deficient mice fail to confirm a primary protective role for CD8 cells in experimental leishmaniasis","volume":"151","author":"Wang ZE","year":"1993","journal-title":"J Immunol."},{"issue":"1","key":"ref88","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1083\/jcb.200510072","article-title":"Cytotoxic T lymphocyte-induced killing in the absence of granzymes A and B is unique and distinct from both apoptosis and perforin-dependent lysis","volume":"173","author":"Waterhouse NJ","year":"2006","journal-title":"J Cell Biol."},{"issue":"1","key":"ref89","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/S1286-4579(02)00057-6","article-title":"The NKG2D receptor and its ligands-recognition beyond the \u201cmissing self\u201d?","volume":"5","author":"Watzl C","year":"2003","journal-title":"Microbes Infect."}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v112n11\/0074-0276-mioc-112-11-0733.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,26]],"date-time":"2025-06-26T20:08:42Z","timestamp":1750968522000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762017001100733&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,11]]},"references-count":89,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2017,11]]}},"alternative-id":["S0074-02762017001100733"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760170109","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2017,11]]}}}