{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T00:17:42Z","timestamp":1791505062590,"version":"4.3.4"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760170542","type":"journal-article","created":{"date-parts":[[2018,5,12]],"date-time":"2018-05-12T15:17:32Z","timestamp":1526138252000},"source":"Crossref","is-referenced-by-count":70,"title":["Analysis of the immunological biomarker profile during acute Zika virus infection reveals the overexpression of CXCL10, a chemokine linked to neuronal damage"],"prefix":"10.1590","volume":"113","author":[{"given":"Felipe Gomes","family":"Naveca","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil; Universidade Federal do Amazonas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemilson Soares","family":"Pontes","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Pesquisas da Amaz\u00f4nia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aileen Yu-hen","family":"Chang","sequence":"additional","affiliation":[{"name":"George Washington University,  United States of America"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George Allan Villarouco da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas,  Brasil; Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valdinete Alves do","family":"Nascimento","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana Cristina da Silva","family":"Monteiro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marineide Souza da","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00edgia Fernandes","family":"Abdalla","sequence":"additional","affiliation":[{"name":"Universidade Federal do Amazonas,  Brasil; Universidade do Estado do Amazonas,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Hugo Abdalla","family":"Santos","sequence":"additional","affiliation":[{"name":"Hospital Adventista de Manaus,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana Amaral Pires de","family":"Almeida","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matilde del Carmen Contreras","family":"Mej\u00eda","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tirza Gabrielle Ramos de","family":"Mesquita","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helia Valeria de Souza","family":"Encarna\u00e7\u00e3o","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus de Souza","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence Rodrigues","family":"Amaral","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina","family":"Campi-Azevedo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jordana Graziela","family":"Coelho-dos-Reis","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lis Ribeiro do Vale","family":"Antonelli","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a","family":"Teixeira-Carvalho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olindo Assis","family":"Martins-Filho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajendranath","family":"Ramasawmy","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o de Medicina Tropical Dr Heitor Vieira Dourado,  Brasil; Universidade Nilton Lins,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1186\/1471-2334-14-391","article-title":"Subdoses of 17DD yellow fever vaccine elicit equivalent virological\/immunological kinetics timeline","volume":"14","author":"Campi-Azevedo AC","year":"2014","journal-title":"BMC Infect Dis"},{"issue":"14","key":"ref2","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.00163-17","article-title":"Selective activation of type II interferon signaling by Zika virus NS5 protein","volume":"91","author":"Chaudhary V","year":"2017","journal-title":"J Virol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1002\/mus.23829","article-title":"The role of chemokines in Guillain-Barr\u00e9 syndrome","volume":"48","author":"Chiang S","year":"2013","journal-title":"Muscle Nerve"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"242","DOI":"10.15585\/mmwr.mm6509e2","article-title":"Increase in reported prevalence of microcephaly in infants born to women living in areas with confirmed Zika virus transmission during the first trimester of pregnancy - Brazil, 2015","volume":"65","author":"de Oliveira WK","year":"2016","journal-title":"MMWR Morb Mortal Wkly Rep"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1016\/j.jaci.2017.07.025","article-title":"Viral infections in allergy and immunology: how allergic inflammation influences viral infections and illness","volume":"140","author":"Edwards MR","year":"2017","journal-title":"J Allergy Clin Immunol"},{"issue":"6537","key":"ref6","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/S0140-6736(48)91599-2","article-title":"The pathogenesis of the acute exanthems; an interpretation based on experimental investigations with mousepox (infectious ectromelia of mice)","volume":"2","author":"Fenner F","year":"1948","journal-title":"Lancet"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"667","DOI":"10.3201\/eid1404.071185","article-title":"Dengue virus type 4, Manaus, Brazil","volume":"14","author":"Figueiredo RMP","year":"2008","journal-title":"Emerging Infect Dis"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1093\/ofid\/ofw203","article-title":"Zika virus causing encephalomyelitis associated with immunoactivation","volume":"3","author":"Galliez RM","year":"2016","journal-title":"Open Forum Infect Dis"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1080\/14767050701483298","article-title":"CXCL10\/IP-10: a missing link between inflammation and anti-angiogenesis in preeclampsia?","volume":"20","author":"Gotsch F","year":"2007","journal-title":"J Matern Fetal Neonatal Med"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0005263","article-title":"Atorvastatin reduces plasma levels of chemokine (CXCL10) in patients with Crohn's disease","volume":"4","author":"Grip O","year":"2009","journal-title":"PLoS One"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-422X-6-10","article-title":"Development of real time PCR for detection and quantitation of dengue viruses","volume":"6","author":"Gurukumar KR","year":"2009","journal-title":"Virol J"},{"issue":"17","key":"ref12","doi-asserted-by":"crossref","first-page":"8880","DOI":"10.1128\/JVI.00354-15","article-title":"Biology of Zika virus infection in human skin cells","volume":"89","author":"Hamel R","year":"2015","journal-title":"J Virol"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1093\/infdis\/jix261","article-title":"Specific biomarkers associated with neurological complications and congenital central nervous system abnormalities from Zika virus-infected patients in Brazil","volume":"216","author":"Kam Y-W","year":"2017","journal-title":"J Infect Dis"},{"issue":"17","key":"ref14","doi-asserted-by":"crossref","first-page":"11457","DOI":"10.1128\/JVI.79.17.11457-11466.2005","article-title":"Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitis","volume":"79","author":"Klein RS","year":"2005","journal-title":"J Virol"},{"issue":"12","key":"ref15","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1002\/bies.201200099","article-title":"Sex influences immune responses to viruses, and efficacy of prophylaxis and treatments for viral diseases","volume":"34","author":"Klein SL","year":"2012","journal-title":"Bioessays"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"764","DOI":"10.3201\/eid1305.070015","article-title":"Chikungunya virus in US travelers returning from India, 2006","volume":"13","author":"Lanciotti RS","year":"2007","journal-title":"Emerging Infect Dis"},{"issue":"8","key":"ref17","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.3201\/eid1408.080287","article-title":"Genetic and serologic properties of Zika virus associated with an epidemic, Yap state, Micronesia, 2007","volume":"14","author":"Lanciotti RS","year":"2008","journal-title":"Emerging Infect Dis"},{"issue":"3","key":"ref18","first-page":"121","article-title":"CXCL10\/IP-10 in infectious diseases pathogenesis and potential therapeutic implications","volume":"22","author":"Liu M","year":"2011","journal-title":"Cytokine Growth Factor Rev"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1093\/infdis\/jir439","article-title":"Cytokine signatures of innate and adaptive immunity in 17DD yellow fever vaccinated children and its association with the level of neutralizing antibody","volume":"204","author":"Luiza-Silva M","year":"2011","journal-title":"J Infect Dis"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1189\/jlb.1102577","article-title":"Expression and function of chemokines during viral infections: from molecular mechanisms to in vivo function","volume":"74","author":"Melchjorsen J","year":"2003","journal-title":"J Leukoc Biol"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1051\/vetres:2004021","article-title":"African horse sickness","volume":"35","author":"Mellor PS","year":"2004","journal-title":"Vet Res"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1590\/0074-02760160062","article-title":"Multiplexed reverse transcription real-time polymerase chain reaction for simultaneous detection of Mayaro, Oropouche, and Oropouche-like viruses","volume":"112","author":"Naveca FG","year":"2017","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"4","key":"ref23","article-title":"IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection","volume":"5","author":"Nie CQ","year":"2009","journal-title":"PLoS Pathog"},{"issue":"9","key":"ref24","doi-asserted-by":"crossref","DOI":"10.2807\/1560-7917.ES2014.19.9.20720","article-title":"Zika virus infection complicated by Guillain-Barre syndrome - case report, French Polynesia, December 2013","volume":"19","author":"Oehler E","year":"2014","journal-title":"Euro Surveill"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1002\/ana.24839","article-title":"Immune activation in amniotic fluid from Zika virus-associated microcephaly","volume":"81","author":"Ornelas AMM","year":"2017","journal-title":"Ann Neurol"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1179\/146532807X220280","article-title":"The role of vascular endothelial growth factor leading to vascular leakage in children with dengue virus infection","volume":"27","author":"Sathupan P","year":"2007","journal-title":"Ann Trop Paediatr"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00430-015-0445-7","article-title":"Cytokine kinetics of Zika virus-infected patients from acute to reconvalescent phase","volume":"205","author":"Tappe D","year":"2016","journal-title":"Med Microbiol Immunol"},{"issue":"10","key":"ref28","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1086\/425016","article-title":"Activation of the cytokine network and unfavorable outcome in patients with yellow fever","volume":"190","author":"ter Meulen J","year":"2004","journal-title":"J Infect Dis"},{"issue":"12","key":"ref29","doi-asserted-by":"crossref","first-page":"1366","DOI":"10.1038\/nm1140","article-title":"Toll-like receptor 3 mediates West Nile virus entry into the brain causing lethal encephalitis","volume":"10","author":"Wang T","year":"2004","journal-title":"Nat Med"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1016\/j.immuni.2012.05.008","article-title":"The chemokine superfamily revisited","volume":"36","author":"Zlotnik A","year":"2012","journal-title":"Immunity"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v113n6\/0074-0276-mioc-0074-02760170542.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,8,1]],"date-time":"2018-08-01T15:20:47Z","timestamp":1533136847000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762018000600303&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":30,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018]]}},"alternative-id":["S0074-02762018000600303"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760170542","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/185041","asserted-by":"object"}]},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2018,5,14]]}}}