{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T03:22:36Z","timestamp":1790997756724,"version":"4.1.0"},"reference-count":30,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,1,1]],"date-time":"2019-01-01T00:00:00Z","timestamp":1546300800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760190111","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T17:54:09Z","timestamp":1565978049000},"source":"Crossref","is-referenced-by-count":25,"title":["Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56\/ARM58 transcripts and reduced drug uptake"],"prefix":"10.1590","volume":"114","author":[{"given":"Jeronimo Nunes","family":"Rugani","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9lia Maria Ferreira","family":"Gontijo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Fr\u00e9zard","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo Pedro","family":"Soares","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4688-2462","authenticated-orcid":false,"given":"Rubens Lima do","family":"Monte-Neto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019]]},"reference":[{"issue":"7","key":"ref1","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.trstmh.2009.04.019","article-title":"Atypical manifestations of tegumentary leishmaniasis in a transmission area of Leishmania braziliensis in the state of Bahia, Brazil","volume":"103","author":"Guimar\u00e3es LH","year":"2009","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"12","key":"ref2","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0005100","article-title":"Atypical manifestations of cutaneous leishmaniasis in a region endemic for Leishmania braziliensis clinical, immunological and parasitological aspects","volume":"10","author":"Guimar\u00e3es LH","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.biopha.2018.09.149","article-title":"Intraspecies susceptibility of Leishmania (Viannia) braziliensis to antileishmanial drugs antimony resistance in human isolates from atypical lesions","volume":"108","author":"Rugani JN","year":"2018","journal-title":"Biomed Pharmacother"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1017\/S0031182018000276","article-title":"Distinct genetic profiles of Leishmania (Viannia) braziliensis associate with clinical variations in cutaneous-leishmaniasis patients from an endemic area in Brazil","volume":"145","author":"Quaresma PF","year":"2018","journal-title":"Parasitology"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.molimm.2013.08.008","article-title":"Gene expression profile of cytokines and chemokines in skin lesions from Brazilian Indians with localized cutaneous leishmaniasis","volume":"57","author":"Costa-Silva MF","year":"2014","journal-title":"Mol Immunol"},{"issue":"Suppl.","key":"ref6","first-page":"1","article-title":"The treatment of kala-azar ? new approaches to an old problem","volume":"73","author":"Peters W","year":"1981","journal-title":"Indian J Med Res"},{"issue":"02","key":"ref7","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0031182010001095","article-title":"Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony","volume":"138","author":"Adaui V","year":"2011","journal-title":"Parasitology"},{"issue":"38","key":"ref8","doi-asserted-by":"crossref","first-page":"39925","DOI":"10.1074\/jbc.M405635200","article-title":"Dual action of antimonial drugs on thiol redox metabolism in the human pathogen Leishmania donovani","volume":"279","author":"Wyllie S","year":"2004","journal-title":"J Biol Chem"},{"issue":"30","key":"ref9","doi-asserted-by":"crossref","first-page":"31010","DOI":"10.1074\/jbc.M403959200","article-title":"Drug uptake and modulation of drug resistance in Leishmania by an aquaglyceroporin","volume":"279","author":"Gourbal B","year":"2004","journal-title":"J Biol Chem"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0003476","article-title":"Intrachromosomal amplification, locus deletion and point mutation in the aquaglyceroporin AQP1 gene in antimony resistant Leishmania (Viannia) guyanensis","volume":"9","author":"Monte-Neto R","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref11","first-page":"145","article-title":"Molecular analysis of Aquaglyceroporin 1 Gene in non-healing clinical isolates obtained from patients with cutaneous leishmaniasis from Central of Iran","volume":"13","author":"Alijani Y","year":"2019","journal-title":"J Arthropod-Borne Dis"},{"issue":"28","key":"ref12","doi-asserted-by":"crossref","first-page":"26301","DOI":"10.1074\/jbc.M102351200","article-title":"The Leishmania ATP-binding cassette protein PGPA is an intracellular metal-thiol transporter ATPase","volume":"276","author":"L\u00e9gar\u00e9 D","year":"2001","journal-title":"J Biol Chem"},{"issue":"5","key":"ref13","article-title":"Gene expression profiling and molecular characterization of antimony resistance in Leishmania amazonensis","volume":"5","author":"Monte-Neto RL","year":"2011","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"3489","DOI":"10.1128\/AAC.02813-15","article-title":"The LABCG2 transporter from the protozoan parasite Leishmania is involved in antimony resistance","volume":"60","author":"Perea A","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1093\/jac\/dkt407","article-title":"Identification of specific reversal agents for Leishmania ABCI4-mediated antimony resistance by flavonoid and trolox derivative screening","volume":"69","author":"Manzano JI","year":"2014","journal-title":"J Antimicrob Chemother"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","first-page":"5262","DOI":"10.1128\/AAC.00544-16","article-title":"A telomeric cluster of antimony resistance genes on chromosome 34 of Leishmania infantum","volume":"60","author":"Tejera Nevado P","year":"2016","journal-title":"Antimicrob Agents Chemother"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"14321","DOI":"10.1038\/s41598-017-14229-8","article-title":"Leishmania infantum lipophosphoglycan induced-Prostaglandin E2 production in association with PPAR- expression via activation of Toll like receptors-1 and 2","volume":"7","author":"Lima JB","year":"2017","journal-title":"Sci Rep"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/S0166-6851(02)00277-3","article-title":"Regulatory volume decrease in Trypanosoma cruzi involves amino acid efflux and changes in intracellular calcium","volume":"126","author":"Rohloff P","year":"2003","journal-title":"Mol Biochem Parasitol"},{"key":"ref19","first-page":"24","article-title":"Biophysical and pharmacological characterization of energy-dependent efflux of Sb in laboratory-selected resistant strains of Leishmania (Viannia) subgenus","volume":"5","author":"dos Reis PG","year":"2017","journal-title":"Front Cell Dev Biol"},{"issue":"6","key":"ref20","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1111\/tmi.13062","article-title":"Unresponsiveness to meglumine antimoniate in anthroponotic cutaneous leishmaniasis field isolates analysis of resistance biomarkers by gene expression profiling","volume":"23","author":"Oliaee RT","year":"2018","journal-title":"Trop Med Int Health"},{"issue":"1","key":"ref21","doi-asserted-by":"crossref","first-page":"69","DOI":"10.4269\/ajtmh.2008.79.69","article-title":"Role of aquaglyceroporin (AQP1) gene and drug uptake in antimony-resistant clinical isolates of Leishmania donovani","volume":"79","author":"Maharjan M","year":"2008","journal-title":"Am J Trop Med Hyg"},{"issue":"6","key":"ref22","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1016\/j.meegid.2010.05.006","article-title":"Targeted gene expression profiling in Leishmania braziliensis and Leishmania guyanensis parasites isolated from Brazilian patients with different antimonial treatment outcomes","volume":"10","author":"Torres DC","year":"2010","journal-title":"Infect Genet Evol"},{"issue":"02","key":"ref23","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1017\/S0031182010001095","article-title":"Comparison of gene expression patterns among Leishmania braziliensis clinical isolates showing a different in vitro susceptibility to pentavalent antimony","volume":"138","author":"Adaui V","year":"2011","journal-title":"Parasitology"},{"issue":"4","key":"ref24","first-page":"370","article-title":"Aquaglyceroporin1 gene expression in antimony resistance and susceptible Leishmania major isolates","volume":"53","author":"Eslami G","year":"2016","journal-title":"J Vector Borne Dis"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ijpddr.2013.11.004","article-title":"A novel marker, ARM58, confers antimony resistance to Leishmania spp","volume":"4","author":"N\u00fchs A","year":"2014","journal-title":"Int J Parasitol Drugs Drug Resist"},{"issue":"6","key":"ref26","doi-asserted-by":"crossref","first-page":"190072","DOI":"10.1098\/rsob.190072","article-title":"Regulation of gene expression in trypanosomatids living with polycistronic transcription","volume":"9","author":"Clayton C","year":"2019","journal-title":"Open Biol"},{"issue":"5","key":"ref27","article-title":"Genome-wide stochastic adaptive DNA amplification at direct and inverted DNA repeats in the parasite Leishmania","volume":"12","author":"Ubeda J-M","year":"2014","journal-title":"PLoS Biol"},{"issue":"12","key":"ref28","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/0169-4758(93)90105-O","article-title":"The lipophosphoglycan of Leishmania and macrophage protein kinase C","volume":"9","author":"Descoteaux A","year":"1993","journal-title":"Parasitol Today (Regul Ed)"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0001543","article-title":"Glycoinositolphospholipids from Leishmania braziliensis and L infantum: modulation of innate immune system and variations in carbohydrate structure","volume":"6","author":"Assis RR","year":"2012","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.ijpara.2004.12.008","article-title":"Leishmania braziliensis a novel mechanism in the lipophosphoglycan regulation during metacyclogenesis","volume":"35","author":"Soares RPP","year":"2005","journal-title":"Int J Parasitol"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v114\/1678-8060-mioc-114-e190111.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,11]],"date-time":"2020-02-11T20:55:19Z","timestamp":1581454519000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762019000100344&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019]]},"references-count":30,"alternative-id":["S0074-02762019000100344"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760190111","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2019]]},"article-number":"e190111"}}