{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T10:52:41Z","timestamp":1790160761658,"version":"4.1.0"},"reference-count":49,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760190498","type":"journal-article","created":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T13:28:24Z","timestamp":1593610104000},"source":"Crossref","is-referenced-by-count":11,"title":["Deep sequencing of small RNAs reveals the repertoire of miRNAs and piRNAs in Biomphalaria glabrata"],"prefix":"10.1590","volume":"115","author":[{"given":"F\u00e1bio Ribeiro","family":"Queiroz","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laysa Gomes","family":"Portilho","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wander de Jesus","family":"Jeremias","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c9lio Hideo","family":"Bab\u00e1","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurence Rodrigues","family":"do Amaral","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Brasil; Universidade Federal de Uberl\u00e2ndia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Maria","family":"Silva","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Ezequiel Dias, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paulo Marcos Zech","family":"Coelho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta Lima","family":"Caldeira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7352-3089","authenticated-orcid":false,"given":"Matheus de Souza","family":"Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Uberl\u00e2ndia, Brasil; Universidade Federal de Uberl\u00e2ndia, Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"key":"ref1","first-page":"15","article-title":"Variation in susceptibility of populations of Australorbis glabratus to a strain of Schistosoma mansoni","volume":"5","author":"Paraense WL","year":"1963","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"743920","DOI":"10.1155\/2012\/743920","article-title":"Interaction of Schistosoma mansoni sporocysts and hemocytes of biomphalaria","volume":"2012","author":"Negrao-Correa D","year":"2012","journal-title":"J. Parasitol Res"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"413","DOI":"10.2307\/3280740","article-title":"Macrophage like hemocytes of resistant Biomphalaria glabrata are cytotoxic for sporocysts of Schistosoma mansoni in vitro","volume":"66","author":"Bayne CJ","year":"1980","journal-title":"J. Parasitol"},{"issue":"11-12","key":"ref4","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1111\/j.1365-3024.2008.01062.x","article-title":"Participation of cell-free haemolymph of Biomphalaria tenagophila in the defence mechanism against Schistosoma mansoni sporocysts","volume":"30","author":"Pereira CA","year":"2008","journal-title":"Parasite Immunol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1016\/0014-4894(84)90034-1","article-title":"Schistosoma mansoni passive transfer of resistance by serum in the vector snail, Biomphalaria glabrata","volume":"58","author":"Granath Jr WO","year":"1984","journal-title":"Exp Parasitol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"15451","DOI":"10.1038\/ncomms15451","article-title":"Whole genome analysis of a schistosomiasis-transmitting freshwater snail","volume":"8","author":"Adema CM","year":"2017","journal-title":"Nat Commun"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0181483","article-title":"Differential expression of small RNA pathway genes associated with the Biomphalaria glabrata\/Schistosoma mansoni interaction","volume":"12","author":"Queiroz FR","year":"2017","journal-title":"PLoS One"},{"issue":"6","key":"ref8","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1007\/s00239-013-9563-2","article-title":"Computational identification and evolutionary relationships of the microRNA gene cluster miR-71\/2 in protostomes","volume":"76","year":"2013","journal-title":"J Mol Evol"},{"issue":"2","key":"ref9","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.ygeno.2011.05.007","article-title":"Genome-wide identification of novel microRNAs and their target genes in the human parasite Schistosoma mansoni","volume":"98","year":"2011","journal-title":"Genomics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1471-2164-12-47","article-title":"Identification of Schistosoma mansoni microRNAs","volume":"12","author":"Simoes MC","year":"2011","journal-title":"BMC Genomics"},{"issue":"7228","key":"ref11","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/nature07756","article-title":"Small RNAs in transcriptional gene silencing and genome defense","volume":"457","author":"Moazed D","year":"2009","journal-title":"Nature"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.0030085","article-title":"Principles of microRNA-target recognition","volume":"3","author":"Brennecke J","year":"2005","journal-title":"PLoS Biology"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"1089","DOI":"10.1016\/j.cell.2007.01.043","article-title":"Discrete small RNA-generating loci as master regulators of transposon activity in Drosophila","volume":"128","author":"Brennecke J","year":"2007","journal-title":"Cell"},{"issue":"6","key":"ref14","doi-asserted-by":"crossref","first-page":"785","DOI":"10.1016\/j.molcel.2008.09.003","article-title":"A piRNA pathway primed by individual transposons is linked to de novo DNA methylation in mice","volume":"31","author":"Aravin AA","year":"2008","journal-title":"Mol Cell"},{"issue":"7099","key":"ref15","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1038\/nature04917","article-title":"A germline-specific class of small RNAs binds mammalian Piwi proteins","volume":"442","author":"Girard A","year":"2006","journal-title":"Nature"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1016\/j.cell.2009.03.040","article-title":"Specialized piRNA pathways act in germline and somatic tissues of the Drosophila ovary","volume":"137","author":"Malone CD","year":"2009","journal-title":"Cell"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1016\/j.cell.2012.02.057","article-title":"A role for neuronal piRNAs in the epigenetic control of memory-related synaptic plasticity","volume":"149","author":"Rajasethupathy P","year":"2012","journal-title":"Cell"},{"issue":"11","key":"ref18","first-page":"882","article-title":"Trends","volume":"33","author":"Huang X","year":"2017","journal-title":"Genet"},{"issue":"7630","key":"ref19","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1038\/nature20162","article-title":"Genetic and mechanistic diversity of piRNA 3'-end formation","volume":"539","author":"Hayashi R","year":"2016","journal-title":"Nature"},{"issue":"4","key":"ref20","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak KJ","year":"2001","journal-title":"Methods"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/0014-4894(80)90043-0","article-title":"Schistosoma mansoni cytotoxicity of hemocytes from susceptible snail hosts for sporocysts in plasma from resistant Biomphalaria glabrata","volume":"50","author":"Bayne CJ","year":"1980","journal-title":"Exp Parasitol"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1158\/1055-9965.EPI-18-0318","article-title":"Circulating PIWI-Interacting RNAs piR-5937 and piR-28876 are promising diagnostic biomarkers of colon cancer","volume":"27","author":"Vychytilova-Faltejskova P","year":"2018","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"ref23","first-page":"3391","article-title":"Overexpression of miR-100 inhibits cell proliferation, migration, and chemosensitivity in human glioblastoma through FGFR3","volume":"8","author":"Luan Y","year":"2015","journal-title":"Onco Targets Ther"},{"issue":"16","key":"ref24","doi-asserted-by":"crossref","first-page":"8057","DOI":"10.1093\/nar\/gkv752","article-title":"Altered expression and editing of miRNA-100 regulates iTreg differentiation","volume":"43","author":"Negi V","year":"2015","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1111\/acel.12673","article-title":"MicroRNAs mir-184 and let-7 alter Drosophila metabolism and longevity","volume":"16","author":"Gendron CM","year":"2017","journal-title":"Aging Cell"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1146\/annurev-biochem-060410-105307","article-title":"Ubiquitin ligases and cell cycle control","volume":"82","author":"Teixeira LK","year":"2013","journal-title":"Ann Rev Biochem"},{"issue":"26","key":"ref27","doi-asserted-by":"crossref","first-page":"42043","DOI":"10.18632\/oncotarget.14927","article-title":"Tumor suppressor miR-1 inhibits tumor growth and metastasis by simultaneously targeting multiple genes","volume":"8","author":"Liu C","year":"2017","journal-title":"Oncotarget"},{"key":"ref28","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.01323","article-title":"microRNA-1 regulates sarcomere formation and suppresses smooth muscle gene expression in the mammalian heart.","volume":"2","author":"Heidersbach A","year":"2013","journal-title":"Elife"},{"issue":"5","key":"ref29","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1242\/dev.140368","article-title":"The E3 ubiquitin ligase Nedd4\/Nedd4L is directly regulated by microRNA 1","volume":"144","author":"Zhu JY","year":"2017","journal-title":"Development"},{"issue":"5","key":"ref30","article-title":"The bantam microRNA acts through Numb to exert cell growth control and feedback regulation of Notch in tumor-forming stem cells in the Drosophila brain","volume":"13","author":"Wu YC","year":"2017","journal-title":"PLoS Genet"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/jemt.1070240303","article-title":"Tracing neural pathways in snail olfaction from the tip of the tentacles to the brain and beyond","volume":"24","author":"Chase R","year":"1993","journal-title":"Microsc Res Tech"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.cmet.2012.02.014","article-title":"The C elegans microRNA mir-71 acts in neurons to promote germline-mediated longevity through regulation of DAF-16\/FOXO","volume":"15","author":"Boulias K","year":"2012","journal-title":"Cell Metab"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039015","article-title":"Signature miRNAs involved in the innate immunity of invertebrates","volume":"7","author":"Yang G","year":"2012","journal-title":"PLoS One"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1186\/1471-2164-13-159","article-title":"Characterization of host microRNAs that respond to DNA virus infection in a crustacean","volume":"13","author":"Huang T","year":"2012","journal-title":"BMC Genomics"},{"issue":"6772","key":"ref35","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1038\/35002607","article-title":"The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans","volume":"403","author":"Reinhart BJ","year":"2000","journal-title":"Nature"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13071-015-0772-y","article-title":"Dynamic expression of miRNAs across immature and adult stages of the malaria mosquito Anopheles stephensi","volume":"8","author":"Jain S","year":"2015","journal-title":"Parasit Vectors"},{"issue":"1","key":"ref37","first-page":"83","article-title":"Dev","volume":"412","author":"Bolin K","year":"2016","journal-title":"Biol"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.dci.2014.03.015","article-title":"Multiple targets of the microRNA miR-8 contribute to immune homeostasis in Drosophila","volume":"45","author":"Lee GJ","year":"2014","journal-title":"Developmental and comparative immunology"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1016\/j.fsi.2016.06.036","article-title":"Cgi-miR-92d indirectly regulates TNF expression by targeting CDS region of lipopolysaccharide-induced TNF-alpha factor 3 (CgLITAF3) in oyster Crassostrea gigas","volume":"55","author":"Chen H","year":"2016","journal-title":"Fish Shellfish Immunol"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"3957","DOI":"10.1096\/fj.09-131847","article-title":"The microRNA miR-92 increases proliferation of myeloid cells and by targeting p63 modulates the abundance of its isoforms","volume":"23","author":"Manni I","year":"2009","journal-title":"FASEB J"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.12659\/MSM.897250","article-title":"MicroRNA-184 promotes proliferation and inhibits apoptosis in HaCaT cells an in vitro study","volume":"22","author":"Bi X","year":"2016","journal-title":"Med Sci Monit"},{"issue":"1","key":"ref42","first-page":"50","article-title":"J Dermatol","volume":"84","author":"Mansuri MS","year":"2016","journal-title":"Sci"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"2645","DOI":"10.1002\/jcb.25856","article-title":"MicroRNA-184 modulates human central nervous system lymphoma cells growth and invasion by targeting iASPP","volume":"118","author":"Liang XG","year":"2017","journal-title":"J Cell Biochem"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"5078627","DOI":"10.1155\/2016\/5078627","article-title":"MicroRNA regulation of endothelial junction proteins and clinical consequence","volume":"2016","author":"Zhuang Y","year":"2016","journal-title":"Mediators Inflamm"},{"issue":"46","key":"ref45","doi-asserted-by":"crossref","first-page":"18151","DOI":"10.1073\/pnas.0706673104","article-title":"Functional screening identifies miR-315 as a potent activator of Wingless signaling","volume":"104","author":"Silver SJ","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"issue":"29","key":"ref46","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000007497","article-title":"Bioinformatics analysis to identify the critical genes, microRNAs and long noncoding RNAs in melanoma","volume":"96","author":"Zhang Q","year":"2017","journal-title":"Medicine (Baltimore)"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.dci.2016.03.002","article-title":"Shrimp miRNAs regulate innate immune response against white spot syndrome virus infection","volume":"60","author":"Kaewkascholkul N","year":"2016","journal-title":"Dev Comp Immunol"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0088397","article-title":"The identification and characteristics of immune-related microRNAs in haemocytes of oyster Crassostrea gigas","volume":"9","author":"Zhou Z","year":"2014","journal-title":"PLoS One"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s42003-018-0141-4","article-title":"PIWI genes and piRNAs are ubiquitously expressed in mollusks and show patterns of lineage-specific adaptation","volume":"1","author":"Jehn J","year":"2018","journal-title":"Commun Biol"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v115\/1678-8060-mioc-115-e190498.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T08:06:46Z","timestamp":1696320406000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762020000100323&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":49,"alternative-id":["S0074-02762020000100323"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760190498","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e190498"}}