{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T04:24:36Z","timestamp":1778905476163,"version":"3.51.4"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760200110","type":"journal-article","created":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T18:27:49Z","timestamp":1603909669000},"source":"Crossref","is-referenced-by-count":6,"title":["CD14 genotype and functional dichotomy of CD14+ and CD14- cells are associated with activated immune response and development of Chagas dilated cardiomyopathy"],"prefix":"10.1590","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3711-5840","authenticated-orcid":false,"given":"Germano Carneiro","family":"Costa","sequence":"first","affiliation":[{"name":"Universidade Federal de Vi\u00e7osa, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manoel Ot\u00e1vio da Costa","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paulo Eduardo Alencar de","family":"Souza","sequence":"additional","affiliation":[{"name":"Pontif\u00edcia Universidade Cat\u00f3lica de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Felipe SA","family":"Melo","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paula Rocha","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kenneth John","family":"Gollob","sequence":"additional","affiliation":[{"name":"AC Camargo Cancer Center, Brazil; Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria do Carmo Pereira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Walderez Ornelas","family":"Dutra","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais, Brazil; Instituto Nacional de Ci\u00eancia e Tecnologia de Doen\u00e7as Tropicais, Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"5283","DOI":"10.1128\/IAI.72.9.5283-5291.2004","article-title":"Monocytes from patients with indeterminate and cardiac forms of Chagas' disease display distinct phenotypic and functional characteristics associated with morbidity","volume":"72","author":"Souza PE","year":"2004","journal-title":"Infect Immun"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1886","DOI":"10.1128\/IAI.01931-06","article-title":"Trypanosoma cruzi infection induces differential modulation of costimulatory molecules and cytokines by monocytes and T cells from patients with indeterminate and cardiac Chagas' disease","volume":"75","author":"Souza PE","year":"2007","journal-title":"Infect Immun"},{"issue":"11","key":"ref3","article-title":"Co-infection with distinct Trypanosoma cruzi strains induces an activated immune response in human monocytes","volume":"41","author":"Magalh\u00e3es LMD","year":"2019","journal-title":"Parasite Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/00130832-200310000-00005","article-title":"The genetics of CD14 in allergic disease","volume":"3","author":"Koppelman GH","year":"2003","journal-title":"Curr Opin Allerg Clin Immun"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"727","DOI":"10.33549\/physiolres.930964","article-title":"Post-hoc analysis on the CD14 C (-260) T promoter polymorphism and coronary heart disease","volume":"56","author":"Porsch-\u00d6zc\u00fcr\u00fcmez M","year":"2007","journal-title":"Physiol Res"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1165\/ajrcmb.20.5.3494","article-title":"A polymorphism in the 5' flanking region of the CD14 gene is associated with circulating soluble CD14 levels and with total serum immunoglobulin E","volume":"20","author":"Baldini M","year":"1999","journal-title":"Am J Respir Cell Mol Biol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1177\/09680519040100060801","article-title":"Regulatory role of toll-like receptor 2 during infection with Trypanosoma cruzi","volume":"10","author":"Ropert C","year":"2004","journal-title":"J Endotoxin Res"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1189\/jlb.0706478","article-title":"Toll-like receptor 4 (TLR4)-dependent proinflammatory and immunomodulatory properties of the glycoinositolphospholipid (GIPL) from Trypanosoma cruzi","volume":"82","author":"Medeiros MM","year":"2007","journal-title":"J Leukoc Biol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1086\/596061","article-title":"Functional IL-10 gene polymorphism is associated with Chagas disease cardiomyopathy","volume":"199","author":"Costa GC","year":"2009","journal-title":"J Infect Dis"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1007\/s00439-020-02130-w","article-title":"Human genetics of leishmania infections","volume":"139","author":"Blackwell JM","year":"2020","journal-title":"Hum Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1186\/1471-2334-13-587","article-title":"Genetic susceptibility to Chagas disease cardiomyopathy involvement of several genes of the innate immunity and chemokine-dependent migration pathways","volume":"13","author":"Frade AF","year":"2013","journal-title":"BMC Infect Dis"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1086\/599212","article-title":"Heterozygosity for the S180L variant of MAL\/TIRAP, a gene expressing an adaptor protein in the toll-like receptor pathway, is associated with lower risk of developing chronic Chagas cardiomyopathy","volume":"199","author":"Ramasawmy R","year":"2009","journal-title":"J Infect Dis"},{"key":"ref13","first-page":"204","article-title":"The differential effect of genetic variation on soluble CD14 levels in human plasma and milk","volume":"52","author":"Guerra S","year":"2004","journal-title":"AJRI"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0171-2985(99)80069-2","article-title":"Expression of surface antigens during the differentiation of human dendritic cells vs macrophages from blood monocytes in vitro","volume":"200","author":"Santin AD","year":"1999","journal-title":"Immunobiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1186\/gb-2005-6-6-223","article-title":"The B7 family of immune-regulatory ligands","volume":"6","author":"Collins M","year":"2005","journal-title":"Genome Biol"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v115\/1678-8060-mioc-115-e200110.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T08:03:04Z","timestamp":1669363384000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762020000100422&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":15,"alternative-id":["S0074-02762020000100422"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760200110","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e200110"}}