{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:10:06Z","timestamp":1790475006183,"version":"4.1.0"},"reference-count":33,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760200401","type":"journal-article","created":{"date-parts":[[2020,10,30]],"date-time":"2020-10-30T18:55:44Z","timestamp":1604084144000},"source":"Crossref","is-referenced-by-count":7,"title":["The secreted acid trehalase encoded by the CgATH1 gene is involved in Candida glabrata virulence"],"prefix":"10.1590","volume":"115","author":[{"given":"Rafael G","family":"Lopes","sequence":"first","affiliation":[{"name":"Universidade Federal de Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n E","family":"Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil; Universidade de S\u00e3o Paulo, Brazil; Universidad del Rosario, Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludmila M","family":"Barros","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio L","family":"Alves-Jr","sequence":"additional","affiliation":[{"name":"Universidade Federal da Fronteira Sul, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos P","family":"Taborda","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo, Brazil; Universidade de S\u00e3o Paulo, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7507-1020","authenticated-orcid":false,"given":"Boris U","family":"Stambuk","sequence":"additional","affiliation":[{"name":"Universidade Federal de Santa Catarina, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2020]]},"reference":[{"issue":"Suppl 1","key":"ref1","doi-asserted-by":"crossref","first-page":"S79","DOI":"10.1093\/ofid\/ofy358","article-title":"Twenty years of the SENTRY antifungal surveillance program Results for Candida species from 1997-2016","volume":"6","author":"Pfaller MA","year":"2019","journal-title":"Open Forum Infect Dis"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"38","DOI":"10.3109\/13693786.2012.698024","article-title":"Candida glabrata an emerging pathogen in Brazilian tertiary care hospitals","volume":"51","author":"Colombo AL","year":"2013","journal-title":"Med Mycol"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1590\/S0074-02762012000300022","article-title":"The activity of echinocandins, amphotericin B and voriconazole against fluconazole-susceptible and fluconazole-resistant Brazilian Candida glabrata isolates","volume":"107","author":"Mario DA","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"9","key":"ref4","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20092345","article-title":"Divergent approaches to virulence in C albicans and C. glabrata: two sides of the same coin","volume":"20","author":"Galocha M","year":"2019","journal-title":"Int J Mol Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1186\/1471-2164-14-623","article-title":"Comparative genomics of emerging pathogens in the Candida glabrata clade","volume":"14","author":"Gabald\u00f3n T","year":"2013","journal-title":"BMC Genomics"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.cub.2010.04.027","article-title":"Rapid expansion and functional divergence of subtelomeric gene families in yeasts","volume":"20","author":"Brown CA","year":"2010","journal-title":"Curr Biol"},{"issue":"5723","key":"ref7","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1126\/science.1108640","article-title":"Nicotinic acid limitation regulates silencing of Candida adhesins during UTI","volume":"308","author":"Domergue R","year":"2005","journal-title":"Science"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0152042","article-title":"Partial decay of thiamine signal transduction pathway alters growth properties of Candida glabrata","volume":"11","author":"Iosue CL","year":"2016","journal-title":"PLoS One"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fmicb.2019.00099","article-title":"Sugar sensing and signaling in Candida albicans and Candida glabrata","volume":"10","author":"Van Ende M","year":"2019","journal-title":"Front Microbiol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1007\/s11046-011-9508-5","article-title":"Evaluation of the commercial rapid trehalose test (GLABRATA RTT) for the point of isolation identification of Candida glabrata isolates in primary cultures","volume":"173","author":"Fraser M","year":"2012","journal-title":"Mycopathologia"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"2771","DOI":"10.1128\/AEM.70.5.2771-2778.2004","article-title":"Two distinct pathways for trehalose assimilation in the yeast Saccharomyces cerevisiae","volume":"70","author":"Jules M","year":"2004","journal-title":"Appl Environ Microbiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.micres.2015.06.008","article-title":"Secretion of the acid trehalase encoded by the CgATH1 gene allows trehalose fermentation by Candida glabrata","volume":"179","author":"Zilli DM","year":"2015","journal-title":"Microbiol Res"},{"issue":"1","key":"ref13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1021\/acs.jproteome.9b00299","article-title":"Global secretome characterization of the pathogenic yeast Candida glabrata","volume":"19","author":"Rasheed M","year":"2020","journal-title":"J Proteome Res"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1007\/s00294-005-0008-3","article-title":"Promoter-dependent disruption of genes simple, rapid, and specific PCR-based method with application to three different yeast","volume":"48","author":"Edlind TD","year":"2005","journal-title":"Curr Genet"},{"key":"ref15","series-title":"The Yeasts: a taxonomic study","author":"Kurtzman CP","year":"2011","edition":"5"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/S0079-6603(08)60037-9","article-title":"Molecular biology of trehalose and the trehalases in the yeast Saccharomyces cerevisiae","volume":"58","author":"Nwaka S","year":"1998","journal-title":"Prog Nucleic Acid Res Mol Biol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001322","article-title":"Host iron withholding demands siderophore utilization for Candida glabrata to survive macrophage killing","volume":"7","author":"Nevitt T","year":"2011","journal-title":"PLoS Pathog"},{"issue":"12","key":"ref18","doi-asserted-by":"crossref","first-page":"6304","DOI":"10.1128\/AAC.00813-12","article-title":"Fks1 and Fks2 are functionally redundant but differentially regulated in Candida glabrata implications for echinocandin resistance","volume":"56","author":"Katiyar SK","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"issue":"6-7","key":"ref19","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.femsyr.2005.01.002","article-title":"Acid trehalase in yeasts and filamentous fungi localization, regulation and physiological function","volume":"5","author":"Parrou JL","year":"2005","journal-title":"FEMS Yeast Res"},{"issue":"2","key":"ref20","doi-asserted-by":"crossref","first-page":"580","DOI":"10.1111\/jam.14161","article-title":"Key amino acid residues of the AGT1 permease required for maltotriose consumption and fermentation by Saccharomyces cerevisiae","volume":"126","author":"Trichez D","year":"2019","journal-title":"J Appl Microbiol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1080\/21505594.2016.1195529","article-title":"Trehalose pathway as an antifungal target","volume":"8","author":"Perfect JR","year":"2017","journal-title":"Virulence"},{"issue":"39","key":"ref22","doi-asserted-by":"crossref","first-page":"40852","DOI":"10.1074\/jbc.M400216200","article-title":"The ATC1 gene encodes a cell wall-linked acid trehalase required for growth on trehalose in Candida albicans","volume":"279","author":"Pedreno Y","year":"2004","journal-title":"J Biol Chem"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1099\/mic.0.2006\/003921-0","article-title":"Disruption of the Candida albicans ATC1 gene encoding a cell-linked acid trehalase decreases hypha formation and infectivity without affecting resistance to oxidative stress","volume":"153","author":"Pedreno Y","year":"2007","journal-title":"Microbiology"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0099113","article-title":"In Candida parapsilosis the ATC1 gene encodes for an acid trehalase involved in trehalose hydrolysis, stress resistance and virulence","volume":"9","author":"S\u00e1nchez-Fresneda R","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1080\/21505594.2016.1199316","article-title":"Trehalase plays a role in macrophage colonization and virulence of Burkholderia pseudomallei in insect and mammalian hosts","volume":"8","author":"Vanaporn M","year":"2017","journal-title":"Virulence"},{"issue":"7688","key":"ref26","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1038\/nature25178","article-title":"Dietary trehalose enhances virulence of epidemic Clostridium difficile","volume":"553","author":"Collins J","year":"2018","journal-title":"Nature"},{"issue":"4","key":"ref27","first-page":"217","article-title":"Analysis of validamycin as a potential antifungal compound against Candida albicans","volume":"16","author":"Guirao-Abad JP","year":"2013","journal-title":"Int Microbiol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"3972415","DOI":"10.1155\/2020\/3972415","article-title":"The inhibitory effect of validamycin A on Aspergillus flavus","volume":"2020","author":"Plabutong N","year":"2020","journal-title":"Int J Microbiol"},{"issue":"34","key":"ref29","doi-asserted-by":"crossref","first-page":"5009","DOI":"10.1039\/C9CC01300H","article-title":"Degradation-resistant trehalose analogues block utilization of trehalose by hypervirulent Clostridioides difficile","volume":"55","author":"Danielson ND","year":"2019","journal-title":"Chem Commun"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1111\/1574-6976.12065","article-title":"Nutrient sensing and signaling in the yeast Saccharomyces cerevisiae","volume":"38","author":"Conrad M","year":"2014","journal-title":"FEMS Microbiol Rev"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/infdis\/173.2.425","article-title":"A murine model of Candida glabrata vaginitis","volume":"173","author":"Fidel PL","year":"1996","journal-title":"J Infect Dis"},{"issue":"3","key":"ref32","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1093\/genetics\/151.3.979","article-title":"Efficient homologous and illegitimate recombination in the opportunistic yeast pathogen Candida glabrata","volume":"151","author":"Cormack BP","year":"1999","journal-title":"Genetics"},{"issue":"6","key":"ref33","doi-asserted-by":"crossref","first-page":"731","DOI":"10.1007\/s11046-019-00404-0","article-title":"The high-quality complete genome sequence of the opportunistic fungal pathogen Candida vulturna CBS 14366T","volume":"184","author":"Navarro-Mu\u00f1oz JC","year":"2019","journal-title":"Mycopathologia"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v115\/1678-8060-mioc-115-e200401.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,11,25]],"date-time":"2022-11-25T22:15:43Z","timestamp":1669414543000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762020000100347&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020]]},"references-count":33,"alternative-id":["S0074-02762020000100347"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760200401","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2020]]},"article-number":"e200401"}}