{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T19:56:56Z","timestamp":1791316616453,"version":"4.3.1"},"reference-count":48,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,1,1]],"date-time":"2021-01-01T00:00:00Z","timestamp":1609459200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760210207","type":"journal-article","created":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T07:02:59Z","timestamp":1636354979000},"source":"Crossref","is-referenced-by-count":22,"title":["Medicines for Malaria Venture COVID Box: a source for repurposing drugs with antifungal activity against human pathogenic fungi"],"prefix":"10.1590","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6639-6058","authenticated-orcid":false,"given":"Rodrigo","family":"Almeida-Paes","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iara Bastos","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariana Lucy Mesquita","family":"Ramos","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcus Vin\u00edcius de Ara\u00fajo","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vin\u00edcius Alves","family":"do Nascimento","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andr\u00e9a Reis","family":"Bernardes-Engemann","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Frases","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2021]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"a019273","DOI":"10.1101\/cshperspect.a019273","article-title":"The spectrum of fungi that infects humans","volume":"5","author":"K\u00f6hler JR","year":"2014","journal-title":"Cold Spring Harb Perspect Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1053\/j.semdp.2019.04.010","article-title":"Emerging and reemerging fungal infections","volume":"36","author":"Lockhart SR","year":"2019","journal-title":"Semin Diagn Pathol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.2217\/fmb-2017-0124","article-title":"The hidden pathogenic potential of environmental fungi","volume":"12","author":"Ara\u00fajo GRS","year":"2017","journal-title":"Future Microbiol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"2352","DOI":"10.1099\/mic.0.081794-0","article-title":"Sporothrix schenckii complex biology environment and fungal pathogenicity","volume":"160","author":"T\u00e9llez MD","year":"2014","journal-title":"Microbiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"67","DOI":"10.3390\/jof5030067","article-title":"Emerging fungal infections new patients, new patterns, and new pathogens","volume":"5","author":"Friedman DZP","year":"2019","journal-title":"J Fungi"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"e367","DOI":"10.1016\/S1473-3099(17)30306-7","article-title":"Neglected endemic mycoses","volume":"17","author":"Queiroz-Telles F","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"S328","DOI":"10.1093\/mmy\/myz012","article-title":"Antifungal drugs what brings the future?","volume":"57","author":"Van Daele R","year":"2019","journal-title":"Med Mycol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"321","DOI":"10.3390\/jof6040321","article-title":"Amphotericin B and other polyenes-discovery, clinical use, mode of action and drug resistance","volume":"6","author":"Carolus H","year":"2020","journal-title":"J Fungi"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4067\/s0716-10182020000300219","article-title":"Azoles de antes y ahora una revisi\u00f3n","volume":"37","author":"Nocua-B\u00e1ez LC","year":"2020","journal-title":"Rev Chilena Infectol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1093\/jac\/46.2.171","article-title":"Flucytosine a review of its pharmacology, clinical indications, pharmacokinetics, toxicity and drug interactions","volume":"46","author":"Vermes A","year":"2020","journal-title":"J Antimicrob Chemother"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"227","DOI":"10.3390\/antibiotics9050227","article-title":"Review on current status of echinocandins use","volume":"9","author":"Mroczynska M","year":"2020","journal-title":"Antibiotics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.pharmthera.2018.10.008","article-title":"Antifungal drugs new insights in research & development","volume":"195","author":"Nicola AM","year":"2019","journal-title":"Pharmacol Ther"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.2217\/fmb-2018-0059","article-title":"Responding to the emergence of antifungal drug resistance perspectives from the bench and the bedside","volume":"13","author":"Beardsley J","year":"2018","journal-title":"Future Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1007\/s40265-017-0805-2","article-title":"Drugs in clinical development for fungal infections","volume":"77","author":"Gonzalez-Lara MF","year":"2017","journal-title":"Drugs"},{"key":"ref15","article-title":"New therapeutic uses for existing drugs. In: Posada de la Paz M, Taruscio D, Groft SC, editors. Rare diseases epidemiology: update and overview","author":"Austin BA","year":"2017","journal-title":"Springer International Publishing"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1159\/000507423","article-title":"COVID-19 outbreak an overview","volume":"64","author":"Ciotti M","year":"2019","journal-title":"Chemotherapy"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1007\/s43440-020-00155-6","article-title":"Drug repurposing approach to fight COVID-19","volume":"72","author":"Singh TU","year":"2020","journal-title":"Pharmacol Rep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/nrd.2018.92","article-title":"Overcoming the legal and regulatory barriers to drug repurposing","volume":"18","author":"Breckenridge A","year":"2019","journal-title":"Nat Rev Drug Discov"},{"key":"ref19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0229630","article-title":"A screening of the MMV Pathogen Box(r) reveals new potential antifungal drugs against the etiologic agents of chromoblastomycosis","volume":"15","author":"Coelho RA","year":"2020","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1405","DOI":"10.2217\/fmb-2020-0156","article-title":"Systemic mycoses a potential alert for complications in COVID-19 patients","volume":"15","author":"Segrelles-Calvo G","year":"2020","journal-title":"Future Microbiol"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008559","article-title":"COVID-19 and acute juvenile paracoccidioidomycosis coinfection","volume":"14","author":"Macedo PM","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1007\/s11046-020-00505-1","article-title":"COVID-19-associated histoplasmosis in an AIDS patient","volume":"186","author":"Basso RP","year":"2021","journal-title":"Mycopathologia"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1016\/j.cmi.2020.06.026","article-title":"Invasive pulmonary fusariosis in an immunocompetent critically ill patient with severe COVID-19","volume":"26","author":"Poignon C","year":"2020","journal-title":"Clin Microbiol Infect"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1111\/myc.13219","article-title":"Prevalence of opportunistic invasive aspergillosis in COVID-19 patients with severe pneumonia","volume":"64","author":"Segrelles-Calvo G","year":"2021","journal-title":"Mycoses"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1016\/j.bsheal.2021.01.001","article-title":"Review of pharmacologic and immunologic agents in the management of COVID-19","volume":"3","author":"Ungogo MA","year":"2021","journal-title":"Biosaf Health"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"211","DOI":"10.3390\/jof6040211","article-title":"COVID-19-associated candidiasis (CAC) an underestimated complication in the absence of immunological predispositions?","volume":"6","author":"Arastehfar A","year":"2020","journal-title":"J Fungi"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3390\/jof7020088","article-title":"Autopsy proven pulmonary mucormycosis due to Rhizopus microsporus in a critically ill COVID-19 patient with underlying hematological malignancy","volume":"7","author":"Zurl C","year":"2021","journal-title":"J Fungi"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1093\/jac\/dkn488","article-title":"Curcumin as a promising antifungal of clinical interest","volume":"63","author":"Martins CVB","year":"2009","journal-title":"J Antimicrob Chemother"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1007\/s11046-010-9359-5","article-title":"Cyclosporin A treatment and decreased fungal load\/antigenemia in experimental murine paracoccidioidomycosis","volume":"171","author":"Massuda TYC","year":"2011","journal-title":"Mycopathologia"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1590\/0037-8682-0230-2017","article-title":"Brazilian guidelines for the clinical management of paracoccidioidomycosis","volume":"50","author":"Shikanai-Yasuda MA","year":"2017","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bjid.2015.11.003","article-title":"Antiretroviral drugs saquinavir and ritonavir reduce inhibitory concentration values of itraconazole against Histoplasma capsulatum strains in vitro","volume":"20","author":"Brilhante RSN","year":"2016","journal-title":"Braz J Infect Dis"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jgar.2020.12.016","article-title":"Advances in Fusarium drug resistance research","volume":"24","author":"Zhao B","year":"2021","journal-title":"J Glob Antimicrob Resist"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1177\/1060028016655425","article-title":"Breaking the mold a review of mucormycosis and current pharmacological treatment options","volume":"50","author":"Riley TT","year":"2016","journal-title":"Ann Pharmacother"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/jac\/dkv446","article-title":"Identification and characterization of haemofungin, a novel antifungal compound that inhibits the final step of haem biosynthesis","volume":"71","author":"Ben Yaakov D","year":"2016","journal-title":"J Antimicrob Chemother"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.2147\/IDR.S247944","article-title":"Current aspects in the biology, pathogeny, and treatment of Candida krusei, a neglected fungal pathogen","volume":"13","author":"G\u00f3mez-Gaviria M","year":"2020","journal-title":"Infect Drug Resist"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3390\/jof6030110","article-title":"Increasing prevalence of multidrug-resistant Candida haemulonii species complex among all yeast cultures collected by a reference laboratory over the past 11 years","volume":"6","author":"Lima SL","year":"2020","journal-title":"J Fungi"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1111\/myc.13296","article-title":"Species distribution, azole resistance and related molecular mechanisms in invasive Candida parapsilosis complex isolates increase in fluconazole resistance in 21 years","volume":"64","author":"Demirci-Duarte S","year":"2021","journal-title":"Mycoses"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1128\/EC.05284-11","article-title":"Rapamycin exerts antifungal activity in vitro and in vivo against Mucor circinelloides via FKBP12-dependent inhibition of Tor","volume":"11","author":"Bastidas RJ","year":"2012","journal-title":"Eukaryot Cell"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4161\/viru.2.4.16764","article-title":"Direct effects of non-antifungal agents used in cancer chemotherapy and organ transplantation on the development and virulence of Candida and Aspergillus species","volume":"2","author":"Chen SCA","year":"2011","journal-title":"Virulence"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"2498","DOI":"10.1016\/j.transproceed.2019.02.048","article-title":"Mucormycosis presented with facial pain in a renal transplant patient a case report","volume":"51","author":"Berktas B","year":"2019","journal-title":"Transplant Proc"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1007\/978-3-319-25304-6_14","article-title":"Antifungals mechanism of action and drug resistance","volume":"892","author":"Prasad R","year":"2016","journal-title":"Adv Exp Med Biol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cellsig.2017.04.001","article-title":"Niclosamide beyond an antihelminthic drug","volume":"41","author":"Chen W","year":"2018","journal-title":"Cell Signal"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"956","DOI":"10.1128\/AAC.47.3.956-964.2003","article-title":"Ergosterol biosynthesis inhibitors become fungicidal when combined with calcineurin inhibitors against Candida albicans, Candida glabrata, and Candida krusei","volume":"47","author":"Onyewu C","year":"2003","journal-title":"Antimicrob Agents Chemother"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1759","DOI":"10.3389\/fmicb.2017.01759","article-title":"Tacrolimus increases the effectiveness of itraconazole and fluconazole against Sporothrix spp","volume":"8","author":"Borba-Santos LP","year":"2017","journal-title":"Front Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"6823","DOI":"10.1007\/s00216-013-7134-4","article-title":"A high-throughput screening assay for assessing the viability of Cryptococcus neoformans under nutrient starvation conditions","volume":"405","author":"Dehdashti SJ","year":"2013","journal-title":"Anal Bioanal Chem"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.ijantimicag.2017.10.017","article-title":"Do antibacterial and antifungal combinations have better activity against clinically relevant Fusarium species In vitro synergism","volume":"51","author":"Venturini TP","year":"2018","journal-title":"Int J Antimicrob Agents"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1099\/jmm.0.46952-0","article-title":"Enhancement of the in vitro activity of amphotericin B against the biofilms of non-albicans Candida spp by rifampicin and doxycycline","volume":"56","author":"El-Azizi M","year":"2007","journal-title":"J Med Microbiol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1128\/AAC.06017-11","article-title":"Potent synergistic effect of doxycycline with fluconazole against Candida albicans is mediated by interference with iron homeostasis","volume":"56","author":"Fiori A","year":"2012","journal-title":"Antimicrob Agents Chemother"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v116\/1678-8060-mioc-116-e210207.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,8]],"date-time":"2021-11-08T07:03:58Z","timestamp":1636355038000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762021000101102&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021]]},"references-count":48,"alternative-id":["S0074-02762021000101102"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760210207","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2021]]},"article-number":"e210207"}}