{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T03:22:04Z","timestamp":1781839324211,"version":"3.54.5"},"reference-count":53,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2022,1,1]],"date-time":"2022-01-01T00:00:00Z","timestamp":1640995200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760220184","type":"journal-article","created":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T08:14:14Z","timestamp":1674807254000},"source":"Crossref","is-referenced-by-count":4,"title":["Intravenous whole blood transfusion results in faster recovery of vascular integrity and increased survival in experimental cerebral malaria"],"prefix":"10.1590","volume":"117","author":[{"given":"Saba","family":"Gul","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans C","family":"Ackerman","sequence":"additional","affiliation":[{"name":"National Institutes of Health,  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udio Tadeu","family":"Daniel-Ribeiro","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0133-6430","authenticated-orcid":false,"given":"Leonardo JM","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2022]]},"reference":[{"key":"ref1","article-title":"World malaria report 2020","year":"2020","journal-title":"20 years of global progress and challenges"},{"key":"ref2","article-title":"Cognitive impairment after cerebral malaria in children: a prospective study","author":"Boivin MJ","year":"2007","journal-title":"Pediatrics"},{"key":"ref3","article-title":"Cerebral malaria in children is associated with long-term cognitive impairment","author":"John CC","year":"2008","journal-title":"Pediatrics"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1399","DOI":"10.1056\/NEJM199505253322102","article-title":"Indicators of life-threatening malaria in African children","volume":"332","author":"Marsh K","year":"1995","journal-title":"N Engl J Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1647","DOI":"10.1016\/S0140-6736(10)61924-1","article-title":"Artesunate versus quinine in the treatment of severe falciparum malaria in African children (AQUAMAT) an open-label, randomised trial","volume":"376","author":"Dondorp AM","year":"2010","journal-title":"Lancet"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3233\/BIR-140654","article-title":"The cellular and molecular rheology of malaria","volume":"51","author":"Cooke BM","year":"2014","journal-title":"Biorheology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1172\/JCI110168","article-title":"Relationship of alterations in splenic clearance function and microcirculation to host defense in acute rodent malaria","volume":"67","author":"Wyler DJ","year":"1981","journal-title":"J Clin Invest"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1080\/17474086.2016.1179571","article-title":"Platelets as pathogenetic effectors and killer cells in cerebral malaria","volume":"9","author":"Wassmer SC","year":"2016","journal-title":"Expert Rev Hematol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/1475-2875-8-295","article-title":"Whole blood angiopoietin-1 and -2 levels discriminate cerebral and severe (non-cerebral) malaria from uncomplicated malaria","volume":"8","author":"Conroy AL","year":"2009","journal-title":"Malar J"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1186\/s12936-015-1028-1","article-title":"Dysregulation of the haem-haemopexin axis is associated with severe malaria in a case-control study of Ugandan children","volume":"14","author":"Elphinstone RE","year":"2015","journal-title":"Malar J"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/nm1499","article-title":"Low nitric oxide bioavailability contributes to the genesis of experimental cerebral malaria","volume":"12","author":"Gramaglia I","year":"2006","journal-title":"Nat Med"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1128\/CVI.00533-16","article-title":"Cytokine profiles in Malawian children presenting with uncomplicated malaria, severe malarial anemia, and cerebral malaria","author":"Mandala WL","year":"2017","journal-title":"Clin Vaccine Immunol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1016\/S2352-3026(20)30288-X","article-title":"The effect of blood transfusion on outcomes among African children admitted to hospital with Plasmodium falciparum malaria a prospective, multicentre observational study","volume":"7","author":"Ackerman H","year":"2020","journal-title":"Lancet Haematol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/S2352-3026(20)30412-9","article-title":"Time-to-death is a potential confounder in observational studies of blood transfusion in severe malaria - Authors' reply","volume":"8","author":"Ackerman H","year":"2021","journal-title":"Lancet Haematol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"12077","DOI":"10.1038\/s41598-021-91499-3","article-title":"Whole blood transfusion improves vascular integrity and increases survival in artemether-treated experimental cerebral malaria","volume":"11","author":"Gul S","year":"2021","journal-title":"Sci Rep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1454","DOI":"10.1093\/infdis\/jir058","article-title":"Nitric oxide protection against murine cerebral malaria is associated with improved cerebral microcirculatory physiology","volume":"203","author":"Cabrales P","year":"2011","journal-title":"J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1742-2094-8-66","article-title":"Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice","volume":"8","author":"Zanini GM","year":"2011","journal-title":"J Neuroinflammation"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15957","DOI":"10.1038\/s41598-018-34249-2","article-title":"Reversal of cerebrovascular constriction in experimental cerebral malaria by L-arginine","volume":"8","author":"Ong PK","year":"2018","journal-title":"Sci Rep"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-49855-x","article-title":"L-arginine supplementation, and thromboxane synthase inhibition increases cerebral blood flow in experimental cerebral malaria","volume":"9","author":"Moreira AS","year":"2019","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1006\/expr.2000.4508","article-title":"Plasmodium berghei cerebral Malaria in CBA mice is not clearly related to plasma TNF levels or intensity of histopathological changes","volume":"95","author":"Carvalho LJM","year":"2000","journal-title":"Exp Parasitol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/1742-2094-8-66","article-title":"Exogenous nitric oxide decreases brain vascular inflammation, leakage and venular resistance during Plasmodium berghei ANKA infection in mice","volume":"8","author":"Zanini GM","year":"2011","journal-title":"J Neuroinflammation"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.2353\/ajpath.2010.090691","article-title":"Murine cerebral malaria is associated with a vasospasm-like microcirculatory dysfunction, and survival upon rescue treatment is markedly increased by nimodipine","volume":"176","author":"Cabrales P","year":"2010","journal-title":"Am J Pathol"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1590\/0074-0276140061","article-title":"Vascular dysfunction as a target for adjuvant therapy in cerebral malaria","volume":"109","author":"Carvalho LJM","year":"2014","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11095-019-2745-x","article-title":"Intraperitoneal route of drug administration should it be used in experimental animal studies?","volume":"37","author":"Al Shoyaib A","year":"2020","journal-title":"Pharm Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1128\/AAC.01277-10","article-title":"Artemether and artesunate show the highest efficacies in rescuing mice with late-stage cerebral malaria and rapidly decrease leukocyte accumulation in the brain","volume":"55","author":"Clemmer L","year":"2011","journal-title":"Antimicrob Agents Chemother"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1097\/CCM.0b013e31828a663e","article-title":"Effects of mesenchymal stem cell therapy on the time course of pulmonary remodeling depend on the etiology of lung injury in mice","volume":"41","author":"Maron-Gutierrez T","year":"2013","journal-title":"Crit Care Med"},{"key":"ref27","first-page":"1","article-title":"Mesenchymal stromal cells protect against vascular damage and depression-like behavior in mice surviving cerebral malaria","volume":"11","author":"Lima MN","year":"2020","journal-title":"Stem Cell Res Ther"},{"issue":"2","key":"ref28","first-page":"CD001475","article-title":"Blood transfusion for treating malarial anaemia","volume":"1999","author":"Meremikwu MM","year":"2000","journal-title":"Cochrane Database Syst Rev"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/S0035-9203(02)90100-8","article-title":"The role of reduced red cell deformability in the pathogenesis of severe falciparum malaria and its restoration by blood transfusion","volume":"96","author":"Dondorp AM","year":"2002","journal-title":"Trans R Soc Trop Med Hyg"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.resuscitation.2007.03.010","article-title":"Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity","volume":"75","author":"Cabrales P","year":"2007","journal-title":"Resuscitation"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1038\/35054560","article-title":"Export by red blood cells of nitric oxide bioactivity","volume":"409","author":"Powloski JR","year":"2001","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"11783","DOI":"10.1073\/pnas.1507309112","article-title":"Piezo1 regulates mechanotransductive release of ATP from human RBCs","volume":"112","author":"Chinar E","year":"2015","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/apha.12596","article-title":"Role of erythrocyte-released ATP in the regulation of microvascular oxygen supply in skeletal muscle","volume":"216","author":"Ellsworth ML","year":"2016","journal-title":"Acta Physiol (Oxf)"},{"key":"ref34","first-page":"562","article-title":"Br","volume":"133","author":"Hollestelle MJ","year":"2006","journal-title":"J Haematol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"17097","DOI":"10.1073\/pnas.0805782105","article-title":"Angiopoietin-2 is associated with decreased endothelial nitric oxide and poor clinical outcome in severe falciparum malaria","volume":"105","author":"Yeo TW","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"4912","DOI":"10.1371\/journal.pone.0004912","article-title":"Serum angiopoietin-1 and -2 levels discriminate cerebral malaria from uncomplicated malaria and predict clinical outcome in African children","volume":"4","author":"Lovegrove FE","year":"2009","journal-title":"PLoS One"},{"key":"ref37","first-page":"213","article-title":"Direct actions of angiopoietin-1 on human endothelium evidence for network stabilization, cell survival, and interaction with other angiogenic growth factors","volume":"79","author":"Papapetropoulos A","year":"1999","journal-title":"Lab Investig"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2278","DOI":"10.1172\/JCI46322","article-title":"Angiopoietin-1 is essential in mouse vasculature during development and in response to injury","volume":"121","author":"Jeansson M","year":"2011","journal-title":"J Clin Invest"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.devcel.2007.10.019","article-title":"Angiopoietin-1 prevents VEGF-induced endothelial permeability by sequestering Src through mDia","volume":"14","author":"Gavard J","year":"2008","journal-title":"Dev Cell"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"15291","DOI":"10.1371\/journal.pone.0015291","article-title":"Endothelium-based biomarkers are associated with cerebral malaria in Malawian children a retrospective case-control study","volume":"5","author":"Conroy AL","year":"2010","journal-title":"PLoS One"},{"key":"ref41","first-page":"8065252","article-title":"Local hematocrit fluctuation induced by malaria-infected red blood cells and its effect on microflow","volume":"2018","author":"Wang T","year":"2018","journal-title":"Biomed Res Int"},{"key":"ref42","first-page":"2636","article-title":"Description of hematocrit in Malaria tropica (Plasmodium falciparum) patients at Jayapura Regional General Hospital","volume":"17","year":"2021","journal-title":"Malaysian J Med Heal Sci"},{"key":"ref43","first-page":"20","article-title":"Evaluation of the effect of whole-blood transfusion on the oxygen status and acid-base balance of Babesia canis infected dogs using the oxygen status algorithm","volume":"67","author":"Leisewitz AL","year":"1996","journal-title":"J S Afr Vet Assoc"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1093\/infdis\/jis400","article-title":"Relative contributions of macrovascular and microvascular dysfunction to disease severity in falciparum malaria","volume":"206","author":"Hanson J","year":"2012","journal-title":"J Infect Dis"},{"key":"ref45","first-page":"788","article-title":"Sequestration and red cell deformability as determinants of hyperlactatemia in falciparum malaria","volume":"212","author":"Ishioka H","year":"2015","journal-title":"J Infect Dis"},{"key":"ref46","first-page":"1216","article-title":"Oxygen delivery during severe anemia when blood transfusion is refused on religious grounds","volume":"14","author":"Salmen M","year":"2017","journal-title":"Ann Am Thorac Soc"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"839","DOI":"10.1046\/j.1365-2141.2002.03904.x","article-title":"Changes in white blood cells and platelets in children with falciparum malaria relationship to disease outcome","volume":"119","author":"Ladhani S","year":"2002","journal-title":"Br J Haematol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12916-015-0324-5","article-title":"The clinical implications of thrombocytopenia in adults with severe falciparum malaria a retrospective analysis","volume":"13","author":"Hanson J","year":"2015","journal-title":"BMC Med"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1016\/j.thromres.2013.09.030","article-title":"Coagulopathy in malaria","volume":"133","author":"Angchaisuksiri P","year":"2014","journal-title":"Thromb Res"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1086\/380761","article-title":"Platelets reorient Plasmodium falciparum-infected erythrocyte cytoadhesion to activated endothelial cells","volume":"189","author":"Wassmer SC","year":"2004","journal-title":"J Infect Dis"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1086\/381900","article-title":"Platelet-induced autoagglutination of Plasmodium falciparum-infected red blood cells and disease severity in Thailand","volume":"189","author":"Chotivanich K","year":"2004","journal-title":"J Infect Dis"},{"key":"ref52","first-page":"2483","article-title":"Mortality after fluid bolus in African children with severe infection","volume":"26","author":"Maitland K","year":"2011","journal-title":"Kenya Med Res Inst (KEMRI)-Well-Come Trust Res Program"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1139","DOI":"10.1097\/CCM.0b013e318283cab1","article-title":"Management of severe malaria enthusiasm for fluid resuscitation dampened by lung water","volume":"41","author":"Ackermann H","year":"2013","journal-title":"Crit Care Med"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0074-02762022000101142&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,1,27]],"date-time":"2023-01-27T08:14:58Z","timestamp":1674807298000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762022000101142&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022]]},"references-count":53,"alternative-id":["S0074-02762022000101142"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760220184","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.12.26.474205","asserted-by":"object"}]},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2022]]},"article-number":"e220184"}}