{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:04:53Z","timestamp":1753887893953,"version":"3.41.2"},"reference-count":55,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760220203","type":"journal-article","created":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T18:32:56Z","timestamp":1680287576000},"source":"Crossref","is-referenced-by-count":1,"title":["Influence of killer immunoglobulin-like receptors genes on the recurrence rate of ocular toxoplasmosis in Brazil"],"prefix":"10.1590","volume":"118","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9596-9505","authenticated-orcid":false,"given":"Daiana de Souza","family":"Perce-da-Silva","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Centro Universit\u00e1rio Arthur S\u00e1 Earp Neto,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thays Euzebio","family":"Joaquim","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Luisa Quintella do Couto","family":"Aleixo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Pessanha Rodrigues","family":"Motta","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Josu\u00e9 da Costa","family":"Lima-Junior","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcelo","family":"Ribeiro-Alves","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joseli","family":"de Oliveira-Ferreira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu\u00eds Crist\u00f3v\u00e3o de Moraes Sobrino","family":"Porto","sequence":"additional","affiliation":[{"name":"Universidade do Estado do Rio de Janeiro,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dalma Maria","family":"Banic","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0867-1445","authenticated-orcid":false,"given":"Maria Regina Reis","family":"Amendoeira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.preteyeres.2013.12.005","article-title":"Ocular toxoplasmosis past, present and new aspects of an old disease","volume":"39","author":"Maenz M","year":"2014","journal-title":"Prog Retin Eye Res"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1017\/S0950268813000526","article-title":"Risk factors for ocular toxoplasmosis in Brazil","volume":"142","author":"Ferreira AI","year":"2014","journal-title":"Epidemiol Infect"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1051\/parasite\/2010173177","article-title":"Factors of occurrence of ocular toxoplasmosis A review","volume":"17","author":"Talabani H","year":"2010","journal-title":"Parasite"},{"key":"ref4","first-page":"100882","article-title":"Pathogenesis of ocular toxoplasmosis","volume":"24","author":"Smith JR","year":"2020","journal-title":"Prog Retin Eye Res"},{"issue":"10","key":"ref5","doi-asserted-by":"crossref","first-page":"e00069","DOI":"10.1128\/IAI.00069-17","article-title":"Down modulation of effector functions in NK cells upon Toxoplasma gondii infection","volume":"85","author":"Sultana MA","year":"2017","journal-title":"Infect Immun"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s12276-019-0353-9","article-title":"Innate, adaptive, and cell-autonomous immunity against Toxoplasma gondii infection","volume":"51","author":"Sasai M","year":"2019","journal-title":"Exp Mol Med"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"1639","DOI":"10.1128\/iai.62.5.1639-1642.1994","article-title":"Interleukin-12 enhances murine survival against acute toxoplasmosis","volume":"62","author":"Khan IA","year":"1994","journal-title":"Infect Immun"},{"issue":"13","key":"ref8","doi-asserted-by":"crossref","first-page":"6115","DOI":"10.1073\/pnas.90.13.6115","article-title":"Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts","volume":"90","author":"Gazzinelli RT","year":"1993","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1038\/s41423-018-0192-y","article-title":"Tissue-resident lymphocytes from adaptive to innate immunity","volume":"16","author":"Sun H","year":"2019","journal-title":"Cell Mol Immunol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.trsl.2021.05.005","article-title":"Immune responses to injury and their links to eye disease","volume":"236","author":"Stepp MA","year":"2021","journal-title":"Transl Res"},{"key":"ref11","article-title":"Immunogenomics of Killer Cell Immunoglobulin-Like Receptor (KIR) and HLA class I: coevolution and consequences for human health","author":"Pollock NR","year":"2022","journal-title":"J Allergy Clin Immunol Pract"},{"issue":"10","key":"ref12","article-title":"Targeted resequencing of candidate genes reveals novel variants associated with severe Beh\u00e7et's uveitis","volume":"45","author":"Kim SJ","year":"2013","journal-title":"Exp Mol Med"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1167\/iovs.09-4232","article-title":"Killer cell immunoglobulin-like receptors in HLA-B27-associated acute anterior uveitis, with and without axial spondyloarthropathy","volume":"51","author":"Levinson RD","year":"2010","journal-title":"Invest Ophthalmol Vis Sci"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3109\/09273948.2010.538798","article-title":"Killer immunoglobulin-like receptor genes in uveitis","volume":"19","author":"Levinson RD","year":"2011","journal-title":"Ocul Immunol Inflamm"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00430-020-00685-z","article-title":"The effect of KIR and HLA polymorphisms on dengue infection and disease severity in northeastern Thais","volume":"209","author":"Chaisri S","year":"2020","journal-title":"Med Microbiol Immunol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.ijid.2020.05.033","article-title":"Natural killer cell receptor variants and chronic hepatitis B virus infection in the Vietnamese population","volume":"96","author":"Auer ED","year":"2020","journal-title":"Int J Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"577241","DOI":"10.1016\/j.jneuroim.2020.577241","article-title":"Protective and causative killer Ig-like receptor (KIR) and metalloproteinase genetic patterns associated with Herpes simplex virus 1 (HSV-1) encephalitis occurrence","volume":"344","author":"Tuttolomondo A","year":"2020","journal-title":"J Neuroimmunol"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1089\/omi.2019.0173","article-title":"Killer Cell Immunoglobulin-Like Receptor genotypes and haplotypes contribute to susceptibility to hepatitis B virus and hepatitis C virus infection in Cameroon","volume":"24","author":"Torimiro J","year":"2020","journal-title":"OMICS"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12879-020-4786-5","article-title":"Clinical and genetic markers associated with tuberculosis, HIV-1 infection, and TB\/HIV-immune reconstitution inflammatory syndrome outcomes","volume":"20","author":"de S\u00e1 NBR","year":"2020","journal-title":"BMC Infect Dis"},{"issue":"9","key":"ref20","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0007696","article-title":"The impact of KIR\/HLA genes on the risk of developing multibacillary leprosy","volume":"13","author":"Alves HV","year":"2019","journal-title":"PLoS Negl Trop Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.actatropica.2017.10.026","article-title":"KIR-like activating natural killer cell receptors and their association with complicated malaria in north India","volume":"178","author":"Prakash S","year":"2018","journal-title":"Acta Trop"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1111\/tan.12523","article-title":"Killer cell immunoglobulin-like receptor (KIR) gene diversity in a population naturally exposed to malaria in Porto Velho, Northern Brazil","volume":"85","author":"Perce-da-Silva DS","year":"2015","journal-title":"Tissue Antigens"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"36632","DOI":"10.1038\/srep36632","article-title":"Ocular toxoplasmosis susceptibility in respect to the genes encoding the KIR receptors and their HLA class I ligands","volume":"6","author":"Ayo CM","year":"2016","journal-title":"Sci Rep"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1016\/j.ijpara.2013.09.007","article-title":"New clinical and experimental insights into Old World and neotropical ocular toxoplasmosis","volume":"44","author":"Pfaff AW","year":"2014","journal-title":"Int J Parasitol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"104465","DOI":"10.1016\/j.micpath.2020.104465","article-title":"Serotyping, host genes and cytokines response in human ocular toxoplasmosis","volume":"148","author":"Mantilla-Muriel LE","year":"2020","journal-title":"Microb Pathog"},{"issue":"5","key":"ref26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004685","article-title":"Toxoplasmic retinochoroiditis clinical characteristics and visual outcome in a prospective study","volume":"10","author":"Aleixo AL","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref27","article-title":"Toxoplasmic retinochoroiditis the influence of age, number of retinochoroidal lesions and genetic polymorphism for IFN-? +874 T\/A as risk factors for recurrence in a survival analysis","volume":"14","author":"Aleixo ALQDC","year":"2019","journal-title":"PLoS One"},{"issue":"1","key":"ref28","first-page":"1","article-title":"Ocular toxoplasmosis a global reassessment. Part II: disease manifestations and management","volume":"137","author":"Holland GN","year":"2004","journal-title":"Am J Ophthalmol"},{"key":"ref29","series-title":"Pepose JS, Holland GN, Wilhelmus KR, editors","first-page":"1183","volume-title":"Toxoplasmosis","author":"Holland GOCG","year":"1996"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1016\/j.ajo.2003.09.040","article-title":"Ocular toxoplasmosis: a global reassessment. Part I: epidemiology and course of disease","volume":"136","author":"Holland GN","year":"2003","journal-title":"Am J Ophthalmol"},{"issue":"9","key":"ref31","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ng2077","article-title":"Global diversity and evidence for coevolution of KIR and HLA","volume":"39","author":"Single RM","year":"2007","journal-title":"Nat Genet"},{"key":"ref32","article-title":"Theory of Point Estimation. Springer Texts in Statistics","author":"Lehmann EL","year":"1998","journal-title":"Springer"},{"journal-title":"R Foundation for Statistical Computing","article-title":"R: a language and environment for statistical computing","year":"2013","key":"ref33"},{"issue":"7","key":"ref34","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.3390\/cells10071777","article-title":"KIR Receptors as key regulators of NK cells activity in health and disease","volume":"10","author":"Debska-Zielkowska J","year":"2021","journal-title":"Cells"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1177\/0961203310385266","article-title":"Systemic lupus erythematosus association with KIR and SLC11A1 polymorphisms, ethnic predisposition and influence in clinical manifestations at onset revealed by ancestry genetic markers in an urban Brazilian population","volume":"20","author":"Pedroza LS","year":"2011","journal-title":"Lupus"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1007\/s00251-011-0565-1","article-title":"Diversity of the KIR gene cluster in an urban Brazilian population","volume":"64","author":"Augusto DG","year":"2012","journal-title":"Immunogenetics"},{"issue":"7","key":"ref37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0039991","article-title":"Activating KIR and HLA Bw4 ligands are associated to decreased susceptibility to pemphigus foliaceus, an autoimmune blistering skin disease","volume":"7","author":"Augusto DG","year":"2012","journal-title":"PLoS One"},{"issue":"5","key":"ref38","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1111\/j.1399-0039.2008.01127.x","article-title":"Association between killer-cell immunoglobulin-like receptor genotypes and leprosy in Brazil","volume":"72","author":"Franceschi DS","year":"2008","journal-title":"Tissue Antigens"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1111\/j.1399-0039.2005.00473.x","article-title":"Genetic diversity of KIR natural killer cell markers in populations from France, Guadeloupe, Finland, Senegal and R\u00e9union","volume":"66","author":"Denis L","year":"2005","journal-title":"Tissue Antigens"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1038\/ni1114","article-title":"Interplay of natural killer cells and their receptors with the adaptive immune response","volume":"5","author":"Raulet DH","year":"2004","journal-title":"Nat Immunol"},{"issue":"10","key":"ref41","article-title":"KIR2DL2 enhances protective and detrimental HLA class I-mediated immunity in chronic viral infection","volume":"7","author":"Seich Al","year":"2011","journal-title":"PLoS Pathog"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005396","article-title":"The diverse role of NK cells in immunity to Toxoplasma gondii infection","volume":"12","author":"Gigley JP","year":"2016","journal-title":"PLoS Pathog"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fcimb.2020.00313","article-title":"NK cells negatively regulate CD8 T cells to promote immune exhaustion and chronic Toxoplasma gondii infection","volume":"10","author":"Ivanova DL","year":"2020","journal-title":"Front Cell Infect Microbiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"2796","DOI":"10.3389\/fimmu.2018.02796","article-title":"Memory-like NK cells remembering a previous activation by cytokines and NK cell receptors","volume":"9","author":"Pahl JHW","year":"2018","journal-title":"Front Immunol"},{"issue":"4","key":"ref45","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1007\/s00251-021-01247-0","article-title":"High-resolution human KIR genotyping","volume":"74","author":"Downing J","year":"2022","journal-title":"Immunogenetics"},{"issue":"7","key":"ref46","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1007\/s00436-021-07204-w","article-title":"The role of IL-12 in stimulating NK cells against Toxoplasma gondii infection a mini-review","volume":"120","author":"Mahmoudzadeh S","year":"2021","journal-title":"Parasitol Res"},{"issue":"13-14","key":"ref47","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.1016\/j.ijpara.2004.10.006","article-title":"Natural killer cells and innate immunity to protozoan pathogens","volume":"34","author":"Korbel DS","year":"2004","journal-title":"Int J Parasitol"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"379","DOI":"10.4049\/jimmunol.2101139","article-title":"KIR2DS2 expression identifies NK cells with enhanced anticancer activity","volume":"209","author":"Blunt MD","year":"2022","journal-title":"J Immunol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0117420","article-title":"Genetic diversity of the KIR\/HLA system and susceptibility to hepatitis C virus-related diseases","volume":"10","author":"De Re V","year":"2015","journal-title":"PLoS One"},{"issue":"16","key":"ref50","doi-asserted-by":"crossref","first-page":"8202","DOI":"10.1128\/JVI.00116-10","article-title":"Influence of HLA class I and HLA-KIR compound genotypes on HIV-2 infection and markers of disease progression in a Manjako community in West Africa","volume":"84","author":"Yindom L-M","year":"2010","journal-title":"J Virol"},{"issue":"11-12","key":"ref51","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1007\/s00251-010-0478-4","article-title":"Linkage disequilibrium organization of the human KIR superlocus implications for KIR data analyses","volume":"62","author":"Gourraud PA","year":"2010","journal-title":"Immunogenetics"},{"issue":"9","key":"ref52","doi-asserted-by":"crossref","first-page":"1114","DOI":"10.1038\/ng2077","article-title":"Global diversity and evidence for coevolution of KIR and HLA","volume":"39","author":"Single RM","year":"2007","journal-title":"Nat Genet"},{"issue":"2","key":"ref53","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1111\/j.1399-0039.2011.01818.x","article-title":"Killer-cell immunoglobulin-like receptors and malaria caused by Plasmodium falciparum in The Gambia","volume":"79","author":"Yindom LM","year":"2012","journal-title":"Tissue Antigens"},{"issue":"1","key":"ref54","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1515\/bmc-2019-0024","article-title":"Role of killer cell immunoglobulin-like receptors (KIR) genes in stages of HIV-1 infection among patients from Burkina Faso","volume":"10","author":"Sorgho PA","year":"2019","journal-title":"Biomol Concepts"},{"issue":"8","key":"ref55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0255608","article-title":"Natural killer-cell immunoglobulin-like receptors trigger differences in immune response to SARS-CoV-2 infection","volume":"16","author":"Littera R","year":"2021","journal-title":"PLoS One"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0074-02762023000101103&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,31]],"date-time":"2023-03-31T18:33:36Z","timestamp":1680287616000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762023000101103&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":55,"alternative-id":["S0074-02762023000101103"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760220203","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"type":"electronic","value":"1678-8060"},{"type":"print","value":"0074-0276"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e220203"}}