{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:04:28Z","timestamp":1787882668113,"version":"build-2784847793"},"reference-count":67,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760230070","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:19:45Z","timestamp":1697195985000},"source":"Crossref","is-referenced-by-count":5,"title":["Differences in responses to the intracellular macrophage environment between Mycobacterium bovis BCG vaccine strains Moreau and Pasteur"],"prefix":"10.1590","volume":"118","author":[{"given":"Paloma Rezende","family":"Corr\u00eaa","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcos Gustavo Araujo","family":"Schwarz","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata Monteiro","family":"Maia","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F\u00e1tima Maria Figueroa","family":"Vergara","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milton Oz\u00f3rio","family":"Moraes","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4388-5083","authenticated-orcid":false,"given":"Leila","family":"Mendon\u00e7a-Lima","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"key":"ref1","year":"2021"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/35085034","article-title":"Mycobacterium tuberculosis here today, and here tomorrow","volume":"2","author":"Russell DG","year":"2001","journal-title":"Nat Rev Mol Cell Biol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1007\/s00018-016-2422-8","article-title":"Molecular basis of mycobacterial survival in macrophages","volume":"74","author":"Awuh JA","year":"2017","journal-title":"Cell Mol Life Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1038\/nm.1795","article-title":"A membrane protein preserves intrabacterial pH in intraphagosomal Mycobacterium tuberculosis","volume":"14","author":"Vandal OH","year":"2008","journal-title":"Nat Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/mmi.12688","article-title":"Slow growth of M ycobacterium tuberculosis at acidic pH is regulated by phoPR and host-associated carbon sources","volume":"94","author":"Baker JJ","year":"2014","journal-title":"Mol Microbiol"},{"key":"ref6","article-title":"Lipid body-phagosome interaction in macrophages during infectious diseases host defense or pathogen survival strategy?","volume":"8","author":"Melo RCN","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"3087","DOI":"10.4049\/jimmunol.176.5.3087","article-title":"Mycobacterium bovis Bacillus Calmette-Gu\u00e9rin induces TLR2-mediated formation of lipid bodies intracellular domains for eicosanoid synthesis in vivo","volume":"176","year":"2006","journal-title":"J Immunol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"70","DOI":"10.4161\/hv.5.2.7210","article-title":"BCG vaccines their mechanisms of attenuation and impact on safety and protective efficacy","volume":"5","author":"Liu J","year":"2009","journal-title":"Hum Vaccin"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1542\/peds.96.1.29","article-title":"The efficacy of Bacillus Calmette-Gue\u00b4rin vaccination of newborns and infants in the prevention of tuberculosis meta-analyses of the published literature","volume":"96","author":"Colditz GA","year":"1995","journal-title":"Pediatrics"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0140-6736(06)68507-3","article-title":"Effect of BCG vaccination on childhood tuberculous meningitis and miliary tuberculosis worldwide a meta-analysis and assessment of cost-effectiveness","volume":"367","author":"Trunz BB","year":"2006","journal-title":"Lancet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1016\/S0140-6736(06)68384-0","article-title":"Global epidemiology of tuberculosis","volume":"367","author":"Dye C","year":"2006","journal-title":"Lancet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1093\/cid\/cit790","article-title":"Protection by BCG vaccine against tuberculosis a systematic review of randomized controlled trials","volume":"58","author":"Mangtani P","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref13","article-title":"Mycobacterium bovis BCG and new vaccines for the prevention of tuberculosis","author":"Lahey T","year":"2016","journal-title":"Microbiol Spectr"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1001\/jama.1994.03510330076038","article-title":"Efficacy of BCG vaccine in the prevention of tuberculosis","volume":"271","author":"Colditz GA","year":"1994","journal-title":"JAMA"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"S64","DOI":"10.1086\/314072","article-title":"Preventing tuberculosis with Bacillus Calmette-Gu\u00e9rin vaccine a meta-analysis of the literature","volume":"31","author":"Brewer TF","year":"2000","journal-title":"Clin Infect Dis"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1016\/S1473-3099(02)00182-2","article-title":"BCG - different strains, different vaccines","volume":"2","author":"Behr MA","year":"2002","journal-title":"Lancet Infect Dis"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2833","DOI":"10.1128\/IAI.01826-06","article-title":"Environmental strains of Mycobacterium avium interfere with immune responses associated with Mycobacterium bovis BCG vaccination","volume":"75","author":"Young SL","year":"2007","journal-title":"Infect Immun"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"15443","DOI":"10.1038\/srep15443","article-title":"Genomic expression catalogue of a global collection of BCG vaccine strains show evidence for highly diverged metabolic and cell-wall adaptations","volume":"5","author":"Abdallah AM","year":"2015","journal-title":"Sci Rep"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1038\/s41598-021-81643-4","article-title":"Leprosy incidence and risk estimates in a 33-year contact cohort of leprosy patients","volume":"11","author":"Hacker MA","year":"2021","journal-title":"Sci Rep"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"5600","DOI":"10.1128\/JB.05827-11","article-title":"Genome sequence of Mycobacterium bovis BCG Moreau, the Brazilian vaccine strain against tuberculosis","volume":"193","author":"Gomes LHF","year":"2011","journal-title":"J Bacteriol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/1471-2180-11-80","article-title":"Proteomic profile of culture filtrate from the Brazilian vaccine strain Mycobacterium bovis BCG Moreau compared to M bovis BCG Pasteur","volume":"11","author":"Berr\u00eado-Pinho M","year":"2011","journal-title":"BMC Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.tube.2013.11.004","article-title":"The BCG Moreau RD16 deletion inactivates a repressor reshaping transcription of an adjacent gene","volume":"94","author":"Galv\u00e3o TC","year":"2014","journal-title":"Tuberculosis"},{"key":"ref23","article-title":"Exploring the potential role of moonlighting function of the surface-associated proteins from Mycobacterium bovis BCG Moreau and Pasteur by comparative proteomic","author":"Pagani TD","year":"2019","journal-title":"Front Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"101956","DOI":"10.1016\/j.tube.2020.101956","article-title":"Mycobacterium bovis BCG Moreau is naturally deficient in homologous recombination","volume":"123","author":"Schwarz MGA","year":"2020","journal-title":"Tuberculosis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"5596","DOI":"10.1073\/pnas.0700869104","article-title":"Genome plasticity of BCG and impact on vaccine efficacy","volume":"104","author":"Brosch R","year":"2007","journal-title":"PNAS"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1080\/21645515.2017.1382788","article-title":"The patterns of in vitro cell-death and inflammatory cytokines induced by distinct BCG vaccine strains are differentially induced in human mononuclear cells","volume":"14","author":"Ponte C","year":"2018","journal-title":"Hum Vaccin Immunother"},{"issue":"11","key":"ref27","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760180267","article-title":"Gain of function in Mycobacterium bovis BCG Moreau due to loss of a transcriptional repressor","volume":"113","author":"Monteiro-Maia R","year":"2018","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"7","key":"ref28","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1590\/S0074-02762001000700015","article-title":"Mycobacterium bovis BCG but not Mycobacterium leprae induces TNF-a Secretion in Human Monocytic THP-1 Cells","volume":"96","author":"Oliveira MM","year":"2001","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"3816","DOI":"10.1038\/s41467-021-24127-3","article-title":"Intracellular localisation of Mycobacterium tuberculosis affects efficacy of the antibiotic pyrazinamide","volume":"12","author":"Santucci P","year":"2021","journal-title":"Nat Commun"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0171817","article-title":"A novel mycobacterial in vitro infection assay identifies differences of induced macrophage apoptosis between CD4+ and CD8+ T cells","volume":"12","author":"Nkwouano V","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"ref31","first-page":"429","article-title":"Mycobacterium leprae infection of human Schwann cells depends on selective host kinases and pathogen-modulated endocytic pathways","volume":"238","author":"Alves L","year":"2004","journal-title":"FEMS Microbiol Lett"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/978-1-60761-950-5_9","article-title":"Imaging lipid bodies within leukocytes with different light microscopy techniques","volume":"689","author":"Melo RCN","year":"2011","journal-title":"Methods Mol Biol"},{"key":"ref33","article-title":"Lipid droplets fuel SARS-CoV-2 replication and production of inflammatory mediators","volume":"16","author":"Dias SSG","year":"2020","journal-title":"PLoS Pathog"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1497","DOI":"10.1128\/iai.65.4.1497-1504.1997","article-title":"Differential trafficking of live and dead Mycobacterium marinum organisms in macrophages","volume":"65","author":"Barker LP","year":"1997","journal-title":"Infect Immun"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"8114","DOI":"10.1016\/j.vaccine.2007.09.041","article-title":"Differential productions of lipid virulence factors among BCG vaccine strains and implications on BCG safety","volume":"25","author":"Chen JM","year":"2007","journal-title":"Vaccine"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"29076","DOI":"10.1038\/srep29076","article-title":"Loss of lipid virulence factors reduces the efficacy of the BCG vaccine","volume":"6","author":"Tran V","year":"2016","journal-title":"Sci Rep"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1574-695X.2009.00559.x","article-title":"Comparable studies of immunostimulating activities in vitro among Mycobacterium bovis bacillus Calmette-Gu\u00e9rin (BCG) substrains","volume":"56","author":"Hayashi D","year":"2009","journal-title":"FEMS Immunol Med Microbiol"},{"key":"ref38","article-title":"Roles for phthiocerol dimycocerosate lipids in Mycobacterium tuberculosis pathogenesis","author":"Rens C","year":"2021","journal-title":"Microbiology"},{"key":"ref39","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000289","article-title":"Phthiocerol dimycocerosates of M tuberculosis participate in macrophage invasion by inducing changes in the organization of plasma membrane lipids","volume":"5","author":"Astarie-Dequeker C","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref40","article-title":"The cell wall lipid PDIM contributes to phagosomal escape and host cell exit of Mycobacterium tuberculosis","author":"Quigley J","year":"2017","journal-title":"mBio"},{"key":"ref41","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1000545","article-title":"Mycobacterium tuberculosis whiB3 maintains redox homeostasis by regulating virulence lipid anabolism to modulate macrophage response","volume":"5","author":"Singh A","year":"2009","journal-title":"PLoS Pathog"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.micpath.2012.06.002","article-title":"A new Mycobacterium tuberculosis smooth colony reduces growth inside human macrophages and represses PDIM operon gene expression Does an heterogeneous population exist in intracellular mycobacteria?","volume":"53","author":"Giovannini D","year":"2012","journal-title":"Microb Pathog"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.4049\/jimmunol.164.4.2016","article-title":"Virulent Mycobacterium tuberculosis strains evade apoptosis of infected alveolar macrophages","volume":"164","author":"Keane J","year":"2000","journal-title":"J Immunol"},{"issue":"2","key":"ref44","first-page":"529","article-title":"On the killing of mycobacteria by macrophages","volume":"10","author":"Jordao L","year":"2008","journal-title":"Cell Microbiol"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1086\/653533","article-title":"Decrease in the effectiveness of Bacille Calmette-Gu\u00e9rin vaccine against pulmonary tuberculosis a consequence of increased immune suppression by microbial antioxidants, not overattenuation","volume":"51","author":"Kernodle DS","year":"2010","journal-title":"Clin Infect Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1054\/tube.2002.0373","article-title":"Characterization of virulence, colony morphotype and the glycopeptidolipid of Mycobacterium avium strain 104","volume":"82","author":"Torrelles JB","year":"2002","journal-title":"Tuberculosis"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1038\/ng.2517","article-title":"Genomic analysis of smooth tubercle bacilli provides insights into ancestry and pathoadaptation of Mycobacterium tuberculosis","volume":"45","author":"Supply P","year":"2013","journal-title":"Nat Genet"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/mmi.12387","article-title":"Identification and characterization of the genetic changes responsible for the characteristic smooth-to-rough morphotype alterations of clinically persistent Mycobacterium abscessus","volume":"90","author":"Pawlik A","year":"2013","journal-title":"Mol Microbiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/j.tube.2005.08.017","article-title":"The role of trehalose dimycolate (cord factor) on morphology of virulent M tuberculosis in vitro","volume":"86","author":"Hunter RL","year":"2006","journal-title":"Tuberculosis"},{"issue":"8","key":"ref50","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1016\/j.tim.2004.06.006","article-title":"Bacterial linguistic communication and social intelligence","volume":"12","author":"Jacob EB","year":"2004","journal-title":"Trends Microbiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1016\/j.arcmed.2010.10.009","article-title":"Reactive oxygen species-activated p38\/ERK 1\/2 MAPK signaling pathway in the Mycobacterium bovis Bacillus Calmette Gu\u00e9rin (BCG)-induced CCL2 secretion in human monocytic cell line THP-1","volume":"41","author":"M\u00e9ndez-Samperio P","year":"2010","journal-title":"Arch Med Res"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"4196","DOI":"10.4049\/jimmunol.1202688","article-title":"IL-1\u00df promotes antimicrobial immunity in macrophages by regulating TNFR signaling and caspase-3 activation","volume":"190","author":"Jayaraman P","year":"2013","journal-title":"J Immunol"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1128\/iai.65.1.298-304.1997","article-title":"Infection by Mycobacterium tuberculosis promotes human alveolar macrophage apoptosis","volume":"65","author":"Keane J","year":"1997","journal-title":"Infect Immun"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1111\/j.1365-2249.2006.03288.x","article-title":"Mycobacterium bovis bacillus Calmette-Gu\u00e9rin (BCG) induces human CC- and CXC-chemokines in vitro and in vivo","volume":"147","author":"Luo Y","year":"2007","journal-title":"Clin Exp Immunol"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.1111\/j.1462-5822.2010.01463.x","article-title":"Effective generation of reactive oxygen species in the mycobacterial phagosome requires K+ efflux from the bacterium","volume":"12","author":"Butler RE","year":"2010","journal-title":"Cell Microbiol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"137","DOI":"10.5551\/jat.10249","article-title":"Diverse bacteria promote macrophage foam cell formation via toll-like receptor-dependent lipid body biosynthesis","volume":"19","author":"Nicolaou G","year":"2012","journal-title":"J Atheroscler Thromb"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1038\/ncb0903-776","article-title":"Phagosomes, fatty acids and tuberculosis","volume":"5","author":"Russell DG","year":"2003","journal-title":"Nat Cell Biol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"5017","DOI":"10.1128\/JB.186.15.5017-5030.2004","article-title":"Induction of a novel class of diacylglycerol acyltransferases and triacylglycerol accumulation in Mycobacterium tuberculosis as it goes into a dormancy-like state in culture","volume":"186","author":"Daniel J","year":"2004","journal-title":"J Bacteriol"},{"key":"ref59","article-title":"A Novel In vitro multiple-stress dormancy model for Mycobacterium tuberculosis generates a lipid-loaded, drug-tolerant, dormant pathogen","volume":"4","author":"Deb C","year":"2009","journal-title":"PLoS One"},{"issue":"10","key":"ref60","doi-asserted-by":"crossref","first-page":"2951","DOI":"10.1099\/00221287-148-10-2951","article-title":"Intracellular lipophilic inclusions of mycobacteria in vitro and in sputum","volume":"148","author":"Garton NJ","year":"2002","journal-title":"Microbiology (Reading)"},{"key":"ref61","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.0050075","article-title":"Cytological and transcript analyses reveal fat and lazy persister-like bacilli in tuberculous sputum","volume":"5","author":"Garton NJ","year":"2008","journal-title":"PLoS Med"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"3866","DOI":"10.1074\/jbc.M505556200","article-title":"A Novel lipase belonging to the hormone-sensitive lipase family induced under starvation to utilize stored triacylglycerol in Mycobacterium tuberculosis","volume":"281","author":"Deb C","year":"2006","journal-title":"J Biol Chem"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"5037","DOI":"10.1128\/JB.00530-09","article-title":"Triacylglycerol utilization is required for regrowth of in vitro hypoxic nonreplicating Mycobacterium bovis Bacillus Calmette-Guerin","volume":"191","author":"Low KL","year":"2009","journal-title":"J Bacteriol"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"21662","DOI":"10.1074\/jbc.M110.135731","article-title":"Lipid droplet-associated proteins are involved in the biosynthesis and hydrolysis of triacylglycerol in Mycobacterium bovis Bacillus Calmette-Gu\u00e9rin","volume":"285","author":"Low KL","year":"2010","journal-title":"J Biol Chem"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1016\/j.chom.2012.09.012","article-title":"Mycobacterium tuberculosis-driven targeted recalibration of macrophage lipid homeostasis promotes the foamy phenotype","volume":"12","author":"Singh V","year":"2012","journal-title":"Cell Host Microbe"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"S353","DOI":"10.1093\/clinids\/11.Supplement_2.S353","article-title":"The BCG Story Lessons from the Past and Implications for the Future","volume":"11","author":"Fine PEM","year":"1989","journal-title":"Clin Infect Dis"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"6911","DOI":"10.1016\/j.vaccine.2014.10.041","article-title":"Persistent BCG bacilli perpetuate CD4 T effector memory and optimal protection against tuberculosis","volume":"32","author":"Kaveh DA","year":"2014","journal-title":"Vaccine"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0074-02762023000101124&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:20:19Z","timestamp":1697196019000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762023000101124&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":67,"alternative-id":["S0074-02762023000101124"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760230070","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e230070"}}