{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T13:46:06Z","timestamp":1765547166626,"version":"3.41.2"},"reference-count":47,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-02760230071","type":"journal-article","created":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T11:37:07Z","timestamp":1695037027000},"source":"Crossref","is-referenced-by-count":9,"title":["First report of putative Leishmania RNA virus 2 (LRV2) in Leishmania infantum strains from canine and human visceral leishmaniasis cases in the southeast of Brazil"],"prefix":"10.1590","volume":"118","author":[{"given":"Felipe Dutra","family":"R\u00eago","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo S\u00e9rgio","family":"da Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valeriana Valadares","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Gon\u00e7alves","family":"Teixeira-Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vin\u00edcius Silva","family":"Belo","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ant\u00f4nio Augusto","family":"Fonseca J\u00fanior","sequence":"additional","affiliation":[{"name":"Minist\u00e9rio da Agricultura, Pecu\u00e1ria e Abastecimento,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Andrade","family":"Pereira","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Heber Paulino","family":"Pena","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Jo\u00e3o Del Rei,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M\u00e1rcia Dalastra","family":"Laurenti","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriela V","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V\u00e2nia L\u00facia Ribeiro","family":"da Matta","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Islam Hussein","family":"Chouman","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thain\u00e1 Bergantin","family":"Burrin","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen M","family":"Sandoval","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stella Maria","family":"Barrouin-Melo","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flaviane Alves","family":"de Pinho","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H\u00e9lida Monteiro","family":"de Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramon Vieira","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C\u00e9lia Maria Ferreira","family":"Gontijo","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanete Thomaz","family":"Soccol","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donnamae","family":"Klocek","sequence":"additional","affiliation":[{"name":"University of Ostrava,  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Danyil","family":"Grybchuk","sequence":"additional","affiliation":[{"name":"University of Ostrava,  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diego Henrique","family":"Macedo","sequence":"additional","affiliation":[{"name":"University of Ostrava,  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rubens Lima","family":"do Monte-Neto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vyacheslav","family":"Yurchenko","sequence":"additional","affiliation":[{"name":"University of Ostrava,  Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7966-3629","authenticated-orcid":false,"given":"Rodrigo Pedro","family":"Soares","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2023]]},"reference":[{"journal-title":"Epidemiological report of the Americas","article-title":"Leishmaniases","year":"2020","key":"ref1"},{"key":"ref2","series-title":"The leishmaniases: old neglected tropical diseases","author":"Bruschi F","year":"2018","edition":"1"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1016\/S0035-9203(01)90223-8","article-title":"The increase in risk factors for leishmaniasis worldwide","volume":"95","author":"Desjeux P","year":"2001","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1007\/s40475-021-00232-7","article-title":"A review of leishmaniasis current knowledge and future directions","volume":"8","author":"Mann S","year":"2021","journal-title":"Curr Trop Med Reports"},{"issue":"6018","key":"ref5","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1126\/science.1199326","article-title":"Leishmania RNA virus controls the severity of mucocutaneous leishmaniasis","volume":"331","author":"Ives A","year":"2011","journal-title":"Science"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3389\/fcimb.2012.00099","article-title":"Leishmania RNA virus when the host pays the toll","volume":"2","author":"Hartley MA","year":"2012","journal-title":"Front Cell Infect Microbiol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"200407","DOI":"10.1098\/rsob.200407","article-title":"Euglenozoa taxonomy, diversity and ecology, symbioses and viruses","volume":"11","author":"Kostygov AY","year":"2021","journal-title":"Open Biol"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1017\/S0031182017001810","article-title":"An overview on Leishmania (Mundinia) enriettii biology, immunopathology, LRV and extracellular vesicles during the host-parasite interaction","volume":"145","author":"Paranaiba LF","year":"2018","journal-title":"Parasitology"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"2305","DOI":"10.3390\/v13112305","article-title":"Analyses of Leishmania-LRV co-phylogenetic patterns and evolutionary variability of viral proteins","volume":"13","author":"Kostygov AY","year":"2021","journal-title":"Viruses"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"657","DOI":"10.3390\/genes12050657","article-title":"The maze pathway of coevolution a critical review over the Leishmania and its endosymbiotic history","volume":"12","author":"Cantanh\u00eade LM","year":"2021","journal-title":"Genes (Basel)"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002836","article-title":"Leishmania aethiopica field isolates bearing an endosymbiontic dsRNA virus induce pro-inflammatory cytokine response","volume":"8","author":"Zangger H","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"425","DOI":"10.4269\/ajtmh.1996.54.425","article-title":"Leishmania RNA viruses in Leishmania of the Viannia subgenus","volume":"54","author":"Salinas G","year":"1996","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"ref13","first-page":"e01932","article-title":"RNA viruses in Blechomonas (Trypanosomatidae) and evolution of","volume":"9","author":"Grybchuk D","year":"2018","journal-title":"Leishmaniavirus. mBio"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"168","DOI":"10.3390\/v12020168","article-title":"The first non-LRV RNA virus in Leishmania","volume":"12","author":"Grybchuk D","year":"2020","journal-title":"Viruses"},{"key":"ref15","article-title":"First report of Leishmania (Mundinia) martiniquensis in South American territory and confirmation of Leishbunyavirus infecting this parasite in a mare","volume":"118","author":"Mendes Jr AAV","year":"2023","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"43","key":"ref16","doi-asserted-by":"crossref","first-page":"11998","DOI":"10.1073\/pnas.1615085113","article-title":"Tilting the balance between RNA interference and replication eradicates Leishmania RNA virus 1 and mitigates the inflammatory response","volume":"113","author":"Brettmann EA","year":"2016","journal-title":"Proc Natl Acad Sci USA"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"5273","DOI":"10.1038\/s41467-019-13356-2","article-title":"Leishmania RNA virus exacerbates leishmaniasis by subverting innate immunity via TLR3-mediated NLRP3 inflammasome inhibition","volume":"10","author":"de Carvalho RVH","year":"2019","journal-title":"Nat Commun"},{"issue":"19","key":"ref18","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.1073\/pnas.1621447114","article-title":"Type I interferons induced by endogenous or exogenous viral infections promote metastasis and relapse of leishmaniasis","volume":"114","author":"Rossi M","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005852","article-title":"Leishmaniavirus-dependent metastatic leishmaniasis is prevented by blocking IL-17A","volume":"12","author":"Hartley MA","year":"2016","journal-title":"PLoS Pathog"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.chom.2016.08.001","article-title":"Mammalian innate immune response to a Leishmania-resident RNA virus increases macrophage survival to promote parasite persistence","volume":"20","author":"Eren RO","year":"2016","journal-title":"Cell Host Microbe"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/s41564-018-0352-y","article-title":"Exploitation of the Leishmania exosomal pathway by Leishmania RNA virus 1","volume":"4","author":"Atayde VD","year":"2019","journal-title":"Nat Microbiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.coi.2020.08.004","article-title":"Leishmania viannia guyanensis, LRV1 virus and extracellular vesicles a dangerous trio influencing the faith of immune response during muco-cutaneous leishmaniasis","volume":"66","author":"Olivier M","year":"2020","journal-title":"Curr Opin Immunol"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1010910","article-title":"Viral endosymbiotic infection of protozoan parasites how it influences the development of cutaneous leishmaniasis","volume":"18","author":"Lafleur A","year":"2022","journal-title":"PLOS Pathog"},{"issue":"4","key":"ref24","article-title":"Elimination of LRVs elicits different responses in","volume":"7","author":"Saura A","year":"2022","journal-title":"Leishmania spp. mSphere"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"2244","DOI":"10.1111\/tbed.13316","article-title":"Global status of synchronizing Leishmania RNA virus in Leishmania parasites a systematic review with meta-analysis","volume":"66","author":"Saberi R","year":"2019","journal-title":"Transbound Emerg Dis"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1093\/infdis\/jiv354","article-title":"Association of the endobiont double-stranded RNA virus LRV1 with treatment failure for human leishmaniasis caused by Leishmania braziliensis in Peru and Bolivia","volume":"213","author":"Adaui V","year":"2016","journal-title":"J Infect Dis"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1093\/infdis\/jix416","article-title":"Influence of Leishmania RNA Virus 1 on proinflammatory biomarker expression in a human macrophage model of American tegumentary leishmaniasis","volume":"216","author":"Kariyawasam R","year":"2017","journal-title":"J Infect Dis"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"102","DOI":"10.4269\/ajtmh.15-0419","article-title":"Prevalence and distribution of Leishmania RNA virus 1 in Leishmania parasites from French Guiana","volume":"94","author":"Ginouv\u00e8s M","year":"2016","journal-title":"Am J Trop Med Hyg"},{"issue":"1-2","key":"ref29","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.molbiopara.2016.08.005","article-title":"Low frequency of LRV1 in Leishmania braziliensis strains isolated from typical and atypical lesions in the State of Minas Gerais, Brazil","volume":"210","author":"Macedo DH","year":"2016","journal-title":"Mol Biochem Parasitol"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1590\/0074-02760210107","article-title":"First report of Leishmania RNA virus 1 in Leishmania (Viannia) braziliensis clinical isolates from Rio de Janeiro State - Brazil","volume":"117","author":"Zabala-Pe\u00f1afiel A","year":"2022","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/viro.1995.1456","article-title":"The complete sequence of Leishmania RNA Virus LRV2-1, a virus of an old world parasite strain","volume":"212","author":"Scheffter SM","year":"1995","journal-title":"Virology"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"3385","DOI":"10.1007\/s00705-016-3044-z","article-title":"Detection and molecular identification of Leishmania RNA virus (LRV) in Iranian Leishmania species","volume":"161","author":"Hajjaran H","year":"2016","journal-title":"Arch Virol"},{"issue":"7","key":"ref33","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1093\/trstmh\/trz023","article-title":"Detection of Leishmania RNA virus 2 in Leishmania species from Turkey","volume":"113","author":"Nal\u00e7aci M","year":"2019","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"10","key":"ref34","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3390\/genes10100830","article-title":"Molecular characterization of Leishmania RNA virus 2 in Leishmania major from Uzbekistan","volume":"10","author":"Kleschenko Y","year":"2019","journal-title":"Genes (Basel)"},{"issue":"2","key":"ref35","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1017\/S0031182022001640","article-title":"Revisiting epidemiology of leishmaniasis in Central Asia lessons learnt","volume":"150","author":"Yurchenko V","year":"2022","journal-title":"Parasitology"},{"issue":"12","key":"ref36","doi-asserted-by":"crossref","first-page":"2300","DOI":"10.1093\/nar\/23.12.2300","article-title":"Phylogenetic analysis of Leishmania RNA virus and Leishmania suggests ancient virus-parasite association","volume":"23","author":"Widmer G","year":"1995","journal-title":"Nucleic Acids Res"},{"issue":"5","key":"ref37","doi-asserted-by":"crossref","first-page":"2294","DOI":"10.1128\/JCM.42.5.2294-2297.2004","article-title":"Culture-independent species typing of neotropical Leishmania for clinical validation of a PCR-based assay targeting heat shock protein 70 genes","volume":"42","author":"Garcia L","year":"2004","journal-title":"J Clin Microbiol"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1093\/molbev\/mst010","article-title":"MAFFT multiple sequence alignment software version 7 improvements in performance and usability","volume":"30","author":"Katoh K","year":"2013","journal-title":"Mol Biol Evol"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1093\/molbev\/msaa015","article-title":"IQ-TREE 2 new models and efficient methods for phylogenetic inference in the genomic era","volume":"37","author":"Minh BQ","year":"2020","journal-title":"Mol Biol Evol"},{"issue":"7","key":"ref40","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1093\/molbev\/msab120","article-title":"MEGA11 molecular evolutionary genetics analysis version 11","volume":"38","author":"Tamura K","year":"2021","journal-title":"Mol Biol Evol"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0255-0857(21)02226-X","article-title":"An insight into the Leishmania RNA virus","volume":"25","author":"Gupta V","year":"2007","journal-title":"Indian J Med Microbiol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.ijid.2020.08.033","article-title":"Presence and diversity of Leishmania RNA virus in an old zoonotic cutaneous leishmaniasis focus, northeastern Iran haplotype and phylogenetic based approach","volume":"101","author":"Saberi R","year":"2020","journal-title":"Int J Infect Dis"},{"issue":"5","key":"ref43","doi-asserted-by":"crossref","first-page":"E811","DOI":"10.1073\/pnas.1619114114","article-title":"Antiviral screening identifies adenosine analogs targeting the endogenous dsRNA Leishmania RNA virus 1 (LRV1) pathogenicity factor","volume":"114","author":"Kuhlmann FM","year":"2017","journal-title":"Proc Natl Acad Sci USA"},{"issue":"17","key":"ref44","doi-asserted-by":"crossref","first-page":"6460","DOI":"10.1074\/jbc.RA117.001515","article-title":"Concentration of 2'C-methyladenosine triphosphate by Leishmania guyanensis enables specific inhibition of Leishmania RNA virus 1 via its RNA polymerase","volume":"293","author":"Robinson JI","year":"2018","journal-title":"J Biol Chem"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004079","article-title":"Further evidence of an association between the presence of Leishmania RNA virus 1 and the mucosal manifestations in tegumentary leishmaniasis patients","volume":"9","author":"Cantanh\u00eade LM","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"309","DOI":"10.4269\/ajtmh.2003.69.309","article-title":"Short report quantification of Leishmaniavirus RNA in clinical samples and it possible role in pathogenesis","volume":"69","author":"Ogg MM","year":"2003","journal-title":"Am J Trop Med Hyg"},{"issue":"5","key":"ref47","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1590\/0074-0276108052013021","article-title":"Severity of tegumentary leishmaniasis is not exclusively associated with Leishmania RNA virus 1 infection in Brazil","volume":"108","author":"Pereira LOR","year":"2013","journal-title":"Mem Inst Oswaldo Cruz"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0074-02762023000101123&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,18]],"date-time":"2023-09-18T11:37:22Z","timestamp":1695037042000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762023000101123&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023]]},"references-count":47,"alternative-id":["S0074-02762023000101123"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760230071","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"type":"electronic","value":"1678-8060"},{"type":"print","value":"0074-0276"}],"subject":[],"published":{"date-parts":[[2023]]},"article-number":"e230071"}}