{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:02:06Z","timestamp":1753887726783,"version":"3.41.2"},"reference-count":26,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p> BACKGROUND  The experience of the USP Tropical Medicine Centre (NUMETROP) team in providing medical care during acute Chagas disease (ACD) outbreaks in Santar\u00e9m, Par\u00e1, motivated this study.  OBJECTIVES  To study the epidemiological, clinical-laboratory, and socio-cultural aspects of confirmed cases of ACD in outbreaks in Santar\u00e9m from March 2016 to March 2018.  METHODS  Observational case series study of ACD outbreaks in two communities: Marimarituba in 2016 and Cachoeira do Aru\u00e3 in 2017. Diagnostic characterisation included classification into discrete typing units (DTUs).  FINDINGS  Eight cases were diagnosed as ACD TcIV in Marimarituba and seven cases were identified as ACD TcI in Cachoeira do Aru\u00e3. Women of childbearing age were numerous in both groups, and one miscarriage and two possible vertical transmissions were observed. Fever and rash were the most common findings in Marimarituba, with a fatality rate of 12.5%. In both outbreaks, serological surveillance was performed three to 21 months after treatment, with no confirmation of a \u201cserological cure\u201d.  MAIN CONCLUSIONS  We observed possible vertical transmission, diverse DTUs in the same municipality, and a lack of knowledge about patient outcomes. We highlight that, despite the importance of ACD in the Amazon region, there is no institutional follow-up of patients from diagnosis to cure.<\/jats:p>","DOI":"10.1590\/0074-02760240108","type":"journal-article","created":{"date-parts":[[2025,4,30]],"date-time":"2025-04-30T02:16:29Z","timestamp":1745979389000},"source":"Crossref","is-referenced-by-count":0,"title":["Acute Chagas disease in Amazonia, western Par\u00e1: perspectives from medical assistance to genetic elucidation"],"prefix":"10.1590","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9270-044X","authenticated-orcid":false,"given":"Helena Rangel","family":"Esper","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade de S\u00e3o Paulo,  Brazil; Secretaria Municipal de Sa\u00fade de Santar\u00e9m,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vera L\u00facia Teixeira","family":"de Freitas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Guilherme Pontes Lima","family":"Assy","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Secretaria Municipal de Sa\u00fade de Santar\u00e9m,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ol\u00edvia Campos Pinheiro","family":"Berreta","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Secretaria Municipal de Sa\u00fade de Santar\u00e9m,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alisson dos Santos","family":"Brand\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Secretaria Municipal de Sa\u00fade de Santar\u00e9m,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika Yoshie 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