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Inst. Oswaldo Cruz"],"abstract":"<jats:p>The 2015-16 Zika virus (ZIKV) epidemic has posed unprecedented concern for maternal-infant health, mainly due to the substantial risk of microcephaly and other neurological birth abnormalities associated with congenital ZIKV syndrome (CZS). As licenced vaccines and effective antivirals are still unavailable, attention has been focused on post-delivery in vitro or translational in vivo studies to understand the impact of maternal ZIKV infection on placentation and neurodevelopmental consequences for the foetus. Here, we review clinical and translational studies highlighting ZIKV-induced maternal-foetal interface dysfunction, adding to our previous observations of experimental ZIKV vertical transmission to pregnant rhesus monkeys and newly published post-epidemic findings about the theme. This comparative review focuses on the mechanisms by which the virus has a cytopathic effect on trophoblasts and macrophages during placentation in humans, nonhuman primates, and rodent transgenic models, crosses the placental barrier, replicates, and establishes a persistent uteroplacental infection. When considering the mechanism of ZIKV-induced birth defects in humans and other susceptible hosts, it becomes apparent how the various stages of the ZIKV cycle in the host (both the parent and offspring) unfold. This understanding presents specific opportunities for pharmacological intervention and the development of preventative vaccines.<\/jats:p>","DOI":"10.1590\/0074-02760240125","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T23:50:52Z","timestamp":1741391452000},"source":"Crossref","is-referenced-by-count":3,"title":["Congenital Zika virus infection in laboratory animals: a comparative review highlights translational studies on the maternal-foetal interface"],"prefix":"10.1590","volume":"120","author":[{"given":"Noemi Rovaris","family":"Gardinali","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil; Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Sergio","family":"Marchevsky","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yara Cavalcante","family":"Vieira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil; The Pennsylvania State University,  USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Pelajo-Machado","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Kugelmeier","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliana Gil","family":"Melga\u00e7o","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00e1rcio Pinto","family":"Castro","sequence":"additional","affiliation":[{"name":"Centro de Diagn\u00f3stico Veterin\u00e1rio,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaqueline Mendes","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Alves","family":"Pinto","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0008527","article-title":"Zika virus transmission by Brazilian Aedes aegypti and Aedes albopictus is virus dose and temperature-dependent","volume":"14","author":"Chouin-Carneiro T","year":"2020","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref2","first-page":"600","article-title":"Uganda S virus A hitherto unrecorded virus isolated from mosquitoes in Uganda. 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