{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:29:17Z","timestamp":1792787357604,"version":"4.5.0"},"reference-count":39,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Universidade Federal do Cear\u00e1","award":["309\/2013"],"award-info":[{"award-number":["309\/2013"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p> BACKGROUND  Single nucleotide polymorphisms (SNP) in genes encoding cytokines influence tuberculosis (TB) outcomes.  OBJECTIVES  To characterise genotypes of the SNPs IFN-gamma +874 T &gt; A, TNF-alpha -308 G &gt; A, IL-6 -174 G &gt; C, IL-10 -1082A &gt; G, TGF-beta codon 10 T &gt; C, and TGF-beta codon 25 G &gt; C in patients with pulmonary (PTB) and extrapulmonary TB (EPTB).  METHODS  82 PTB and 45 EPTB cases were compared, concerning genotype distribution of the mentioned SNPs, characterised via sequence-specific primer polymerase chain reaction (PCR).  FINDINGS  Regarding IFN-gamma +874 T &gt; A, AA genotype was the most frequent in both groups, TA was more frequent in PTB and TT in EPTB, with no statistical significance. For SNP TNF-alpha -308 G &gt; A, GG was more frequent in both groups of patients. Regarding the IL-6 -174 G &gt; C polymorphism, GG predominated in both groups, while CG and GG were significantly more frequent in patients with PTB and EPTB, respectively. Concerning IL-10 -1082 A &gt; G, AA predominated in both PTB and EPTB. Concerning TGF-beta codon 10 T &gt; C, CC predominated in PTB while TC predominated in EPTB, but the differences were not statistically significant. Genotype GG of TGF-beta codon 25 G &gt; C predominated among PTB and EPTB patients.  MAIN CONCLUSIONS  Except for IL-6, the genotype profile could not differentiate PTB and EPTB. Hence, the studied SNPs are not significantly associated with the extrapulmonary involvement of TB.<\/jats:p>","DOI":"10.1590\/0074-02760240147","type":"journal-article","created":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T10:57:57Z","timestamp":1747393077000},"source":"Crossref","is-referenced-by-count":4,"title":["Single nucleotide polymorphisms in IFN-gamma, TNF-alpha, IL-6, IL-10, and TGF-beta in pulmonary and extrapulmonary tuberculosis in the State of Cear\u00e1, northeastern Brazil"],"prefix":"10.1590","volume":"120","author":[{"given":"Roberta dos Santos Silva","family":"Luiz","sequence":"first","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thales Alves","family":"Campelo","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroliny Soares","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas de Lima","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya de Oliveira","family":"Sancho","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Karolliny Alves","family":"da Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristiane Cunha","family":"Frota","sequence":"additional","affiliation":[{"name":"Universidade Federal do Cear\u00e1,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8083-2840","authenticated-orcid":false,"given":"Filipe Anibal","family":"Carvalho-Costa","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.1016\/S0140-6736(19)30308-3","article-title":"Tuberculosis","volume":"393","author":"Furin J","year":"2019","journal-title":"Lancet"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.ijtb.2020.02.005","article-title":"A systemic review on tuberculosis","volume":"67","author":"Natarajan A","year":"2020","journal-title":"Indian J Tuberc"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.jctube.2016.03.003","article-title":"Miliary tuberculosis a 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