{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T07:42:20Z","timestamp":1791618140942,"version":"4.3.4"},"reference-count":11,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"FAPERJ","doi-asserted-by":"crossref","award":["SEI-260003\/019688\/2022"],"award-info":[{"award-number":["SEI-260003\/019688\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p> BACKGROUND  Non-O1 and non-O139 Vibrio cholerae (NOVC) that cause bacteraemia have attracted the attention of the public health community around the world, mainly due to the prospect of outbreaks and the way to treat such infections.  OBJECTIVES  To identify V. cholerae lineages and their antibiotic resistance and virulence factors associated with bacteraemia.  METHODS Vibrio cholerae genomes associated with strains isolated from blood were retrieved and subjected to core genome-based phylogenomic analysis with Roary. The virulome and resistome were searched with abricate using the VFDB and CARD databases.  FINDINGS  Analysis showed that, in addition to V. cholerae, Vibrio paracholerae also causes bacteraemia. The NOVC group was highly diverse, although genomes from different countries were related. Most bacteraemic Vibrios came from countries not affected by epidemic\/endemic cholera. The NOVCs virulome presented factors, such as type III and VI secretion systems, HapA, HlyA, RTX, and TLH. Importantly, no resistance to third-generation cephalosporin has been identified in the resistome of NOVCs.  MAIN CONCLUSIONS  The presence of multiple NOVC lineages that cause bacteraemia in different parts of the world shows that there is no geographic and socioeconomic restriction for these cases. Therefore, healthcare systems need to be aware of this uncommon but deadly Vibrio infection.<\/jats:p>","DOI":"10.1590\/0074-02760240159","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:30:02Z","timestamp":1738582202000},"source":"Crossref","is-referenced-by-count":5,"title":["Vibrio cholerae and Vibrio paracholerae bacteraemia strains encompass lineages that share resistome and virulome profiles"],"prefix":"10.1590","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4877-7639","authenticated-orcid":false,"given":"Sergio Mascarenhas","family":"Morgado","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erica Louren\u00e7o","family":"da Fonseca","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Carolina Paulo","family":"Vicente","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brasil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.3390\/tropicalmed9050103","article-title":"Vibrio cholerae bacteremia an enigma in cholera-endemic African countries","volume":"9","author":"Agyei FK","year":"2024","journal-title":"Trop Med Infect Dis"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1186\/s40064-015-1346-3","article-title":"Non-O1, non-O139 Vibrio cholerae bacteraemia case report and literature review","volume":"4","author":"Deshayes S","year":"2015","journal-title":"Springerplus"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.2147\/IDR.S245806","article-title":"Non-O1, Non-O139 Vibrio cholerae (NOVC) bacteremia case report and literature review, 2015-2019","volume":"13","author":"Zhang X","year":"2020","journal-title":"Infect Drug Resist"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"105587","DOI":"10.1016\/j.meegid.2024.105587","article-title":"German coasts harbor non-O1\/non-O139 Vibrio cholerae with clinical virulence gene profiles","volume":"120","author":"Zhang Q","year":"2024","journal-title":"Infect Genet Evol"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","DOI":"10.1099\/jmmcr.0.005077","article-title":"Non-O1\/non-O139 Vibrio cholerae septicaemia in a Saudi man a case report","volume":"4","author":"Kaki R","year":"2017","journal-title":"JMM Case Rep"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"323","DOI":"10.7705\/biomedica.6716","article-title":"Bacteremia by non-O1\/non-O139 Vibrio cholerae case description and literature review","volume":"43","author":"Rodr\u00edguez JY","year":"2023","journal-title":"Biomedica"},{"issue":"4","key":"ref7","article-title":"Bacteremia caused by a serotype Ob5 Vibrio cholerae strain in a cirrhotic patient in China","volume":"11","author":"Xu X","year":"2023","journal-title":"Microbiol Spectr"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1111\/imj.16187","article-title":"Vibrio species bloodstream infections in Queensland, Australia","volume":"54","author":"Davidson N","year":"2024","journal-title":"Intern Med J"},{"issue":"17","key":"ref9","doi-asserted-by":"crossref","DOI":"10.1128\/AEM.00422-21","article-title":"Population analysis of Vibrio cholerae in aquatic reservoirs reveals a novel sister species (Vibrio paracholerae sp nov.) with a history of association with humans","volume":"87","author":"Islam MT","year":"2021","journal-title":"Appl Environ Microbiol"},{"issue":"2","key":"ref10","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/1758-2229.13136","article-title":"First report on the occurrence of Vibrio cholerae nonO1\/nonO139 in natural and artificial lakes and ponds in Serbia evidence for a long-distance transfer of strains and the presence of vibrio paracholerae","volume":"15","author":"Rehm C","year":"2023","journal-title":"Environ Microbiol Rep"},{"key":"ref11","first-page":"144","article-title":"The pathogenesis, detection, and prevention of Vibrio parahaemolyticus","volume":"6","author":"Wang R","year":"2015","journal-title":"Front Microbiol"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0074-02762025000101100&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:30:08Z","timestamp":1738582208000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762025000101100&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":11,"alternative-id":["S0074-02762025000101100"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760240159","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e240159"}}