{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T15:01:42Z","timestamp":1753887702223,"version":"3.41.2"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006181","name":"FAPESB","doi-asserted-by":"crossref","award":["APP.0048\/2023"],"award-info":[{"award-number":["APP.0048\/2023"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006181","name":"FAPESB","doi-asserted-by":"crossref","award":["PROPG\/UFBA 007\/2022"],"award-info":[{"award-number":["PROPG\/UFBA 007\/2022"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100006181","name":"FAPESB","doi-asserted-by":"crossref","award":["101878\/2022-2"],"award-info":[{"award-number":["101878\/2022-2"]}],"id":[{"id":"10.13039\/501100006181","id-type":"DOI","asserted-by":"crossref"}]},{"name":"PROPCI","award":["APP.0048\/2023"],"award-info":[{"award-number":["APP.0048\/2023"]}]},{"name":"PROPCI","award":["PROPG\/UFBA 007\/2022"],"award-info":[{"award-number":["PROPG\/UFBA 007\/2022"]}]},{"name":"PROPCI","award":["101878\/2022-2"],"award-info":[{"award-number":["101878\/2022-2"]}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["APP.0048\/2023"],"award-info":[{"award-number":["APP.0048\/2023"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["PROPG\/UFBA 007\/2022"],"award-info":[{"award-number":["PROPG\/UFBA 007\/2022"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["101878\/2022-2"],"award-info":[{"award-number":["101878\/2022-2"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p> BACKGROUND  The HTLV-1 affects 5 to 10 million people worldwide. It is estimated that 5 to 10% of the infected individuals develop severe diseases, such as HTLV-Associated Myelopathy\/Tropical Spastic Paraparesis (HAM\/TSP) or Adult T-Cell Leukaemia\/Lymphoma (ATLL). HTLV-1 transmission can occur mainly through unprotected sexual contact and from mother to child during breastfeeding. No vaccines can contain this infection, and strategies to prevent transmission become a priority. Therefore, it is important to know the main dissemination routes of each region to design the best public health strategies for controlling the spread of this virus.  OBJECTIVES  This study aimed to evaluate the prevalence of family aggregation in HTLV-1 infection among patients treated at a reference centre in Brazil.  METHODS  A cross-sectional study was conducted with patients between July 2021 and August 2022. A total of 67 individuals were attended, of which 17 were classified as index cases due to a history of family aggregation, with 120 family contacts.  FINDINGS  We found a prevalence of 36% of individuals positive for HTLV-1 and the same for HTLV-1 negative, while 28% of the family members had unknown serology. The possible transmission routes were identified, and the familial transmission histories within each family were hypothesised.  MAIN CONCLUSIONS  These data can support specific decisions regarding the local reality, such as a better health strategy, especially in preventing new HTLV-1 cases.<\/jats:p>","DOI":"10.1590\/0074-02760240191","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T21:45:57Z","timestamp":1743198357000},"source":"Crossref","is-referenced-by-count":1,"title":["Silent dissemination of HTLV-1: evidence of intrafamilial transmission in a Brazilian reference centre"],"prefix":"10.1590","volume":"120","author":[{"given":"Daniele Leite","family":"Alves","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil; Laborat\u00f3rio Central de Vit\u00f3ria da Conquista,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Muniz Luz","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o Pedro Melo de Freitas","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rebeca Le\u00e3o","family":"Amorim","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina Souza","family":"Santana","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felipe de Oliveira","family":"Andrade","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saadia Oliveira","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro de Suporte e Apoio \u00e0 Vida,  Brasil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giselle Calasans de Souza","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciane Amorim","family":"Santos","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davi Tanajura","family":"Costa","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil; Universidade Estadual do Sudoeste da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0088-9036","authenticated-orcid":false,"given":"Fernanda Khouri","family":"Barreto","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"388","DOI":"10.3389\/fmicb.2012.00388","article-title":"Epidemiological aspects and world distribution of HTLV-1 infection","volume":"3","author":"Gessain A","year":"2012","journal-title":"Front Microbiol"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1590\/S0102-311X2005000300027","article-title":"Heterogeneous geographic distribution of human T-cell lymphotropic viruses I and II (HTLV-I\/II) serological screening prevalence rates in blood donors from large urban areas in Brazil","volume":"21","author":"Catalan-Soares B","year":"2005","journal-title":"Cad Sa\u00fade Publica"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1097\/00126334-200312150-00013","article-title":"HTLV-I in the general population of Salvador, Brazil 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