{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T03:30:16Z","timestamp":1778902216202,"version":"3.51.4"},"reference-count":45,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p>The history of the plague, caused by Yersinia pestis, is marked by some of the most devastating pandemics. Its arrival in Brazil on the turn of the 19-20th century led to significant public health challenges and responses. Here, we discuss a comprehensive perspective on the history of the plague in Brazil, emphasising epidemiological trends, public health responses and scientific advances. Understanding the history of the plague in Brazil provides valuable insights into infectious disease control. The study highlights the importance of early detection, robust public health infrastructure, and ongoing research, emphasising the lasting influence of epidemic diseases on society.<\/jats:p>","DOI":"10.1590\/0074-02760240220","type":"journal-article","created":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:30:17Z","timestamp":1738582217000},"source":"Crossref","is-referenced-by-count":4,"title":["125 years of the plague in Brazil: lessons learnt, historical insights and contemporary challenges"],"prefix":"10.1590","volume":"120","author":[{"given":"Igor Vasconcelos","family":"Rocha","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matheus Filgueira","family":"Bezerra","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marise","family":"Sobreira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8304-3182","authenticated-orcid":false,"given":"Alzira Maria Paiva","family":"de Almeida","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"issue":"1","key":"ref1","first-page":"1","article-title":"Yersinia pestis the natural history of Plague","volume":"34","author":"Barbieri R","year":"2021","journal-title":"Clin Microbiol Rev"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"820","DOI":"10.1111\/1749-4877.12511","article-title":"Plague reservoir species throughout the world","volume":"16","author":"Mahmoudi A","year":"2021","journal-title":"Integr Zoology"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3390\/biom11050724","article-title":"Antibiotic therapy of Plague a review","volume":"11","author":"Sebbane F","year":"2021","journal-title":"Biomolecules"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"65","DOI":"10.4321\/S0211-95362011000100004","article-title":"La llegada de la peste al Estado de S\u00e3o Paulo en 1899","volume":"31","author":"Nascimento DR","year":"2011","journal-title":"Dynamis"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1007\/978-1-4614-3561-7_10","article-title":"Plague in Brazil from now and then","volume":"954","author":"Tavares C","year":"2012","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"ref6","first-page":"35","article-title":"Journey(s) to Santos","volume":"5","author":"Cukierman HL","year":"1998","journal-title":"Hist Cienc Saude-Manguinhos"},{"issue":"6","key":"ref7","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1111\/1749-4877.12480","article-title":"Rodent hosts and flea vectors in Brazilian plague foci a review","volume":"16","author":"Fernandes DLRS","year":"2021","journal-title":"Integr Zool"},{"key":"ref8","series-title":"A vaccina\u00e7\u00e3o anti-pestosa - Trabalho do Instituto S\u00f4rother\u00e1pico Federal do Rio de Janeiro (Instituto de Manguinhos)","author":"Cruz OG","year":"1901"},{"key":"ref9","series-title":"Peste","author":"Cruz OG","year":"1906"},{"key":"ref10","article-title":"Important infectious diseases in Latin America and the Caribbean: Plague","author":"Bezerra MF","year":"2022","journal-title":"Springer"},{"issue":"4","key":"ref11","first-page":"64","article-title":"Spatiotemporal analysis of bubonic plague in Pernambuco, northeast of Brazil case study in the municipality of Exu","volume":"16","author":"Fernandes DLRS","year":"2021","journal-title":"PLoS One"},{"key":"ref12","article-title":"Nota T\u00e9cnica 001","year":"2007","journal-title":"Programa de Controle da Peste"},{"key":"ref13","series-title":"Hist\u00f3rias da Peste e de outras endemias","author":"Freitas CA","year":"1988"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1590\/S0074-02761909000100003","article-title":"O s\u00f4ro anti-pestozo","volume":"1","author":"Vasconcellos F","year":"1909","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref15","article-title":"Plague. World Health Organization monograph series","author":"Pollitzer R","year":"1954","journal-title":"World Health Organization"},{"issue":"1","key":"ref16","first-page":"576","article-title":"Plague in the Americas an historical and quasi-epidemiological survey","volume":"19","author":"Moll AA","year":"1940","journal-title":"Pan Am Health Org"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1093\/cid\/ciz1230","article-title":"Treatment of human plague a systematic review of published aggregate data on antimicrobial efficacy, 1939-2019","volume":"70","author":"Godfred-Cato S","year":"2020","journal-title":"Clin Infect Dis"},{"key":"ref18","series-title":"Manual de vigil\u00e2ncia e controle da Peste","year":"2008"},{"issue":"294","key":"ref19","first-page":"92","article-title":"Guerra \u00e0 Peste","volume":"21","author":"Fioravanti C","year":"2020","journal-title":"Pesq Fapesp"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1371\/journal.pntd.0000421","article-title":"Development and evaluation of two simple, rapid immunochromatographic tests for the detection of Yersinia pestis antibodies in humans and reservoirs","volume":"3","author":"Rajerison M","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"1465","DOI":"10.1111\/jam.12465","article-title":"Application of r-PFE hyperimmune sera for concurrent detection of Bacillus anthracis, Yersinia pestis and staphylococcal enterotoxin B","volume":"116","author":"Balakrishna K","year":"2014","journal-title":"J Appl Microbiol"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1371\/journal.pntd.0009805","article-title":"Evaluation of a multi-species Protein A-ELISA assay for plague serologic diagnosis in humans and other mammal hosts","volume":"16","author":"Bezerra MF","year":"2022","journal-title":"PLoS Negl Trop Dis"},{"issue":"1","key":"ref23","first-page":"23","article-title":"Technical report series WHO Expert Committee on Plague. Fourth Report","volume":"447","year":"1970","journal-title":"World Health Organization Bulletin"},{"issue":"4","key":"ref24","first-page":"22","article-title":"Approaches for the inactivation of Yersinia pestis","volume":"1","author":"Brady A","year":"2024","journal-title":"Appl Biosaf"},{"key":"ref25","article-title":"Laboratory manual of plague diagnostic tests","author":"Chu M","year":"2000","journal-title":"Centers for Disease Control and Prevention\/World Health Organization"},{"issue":"1","key":"ref26","first-page":"105","article-title":"A new recombinant F1 antigen as a cost and time-effective tool for plague diagnosis","volume":"172","author":"Tavares DHC","year":"2020","journal-title":"J Microbiol Methods"},{"issue":"2","key":"ref27","first-page":"126","article-title":"Estudo comparativo entre as t\u00e9cnicas de hemaglutina\u00e7\u00e3o e aglutina\u00e7\u00e3o bacteriana no diagn\u00f3stico da peste humana","volume":"18","author":"Almeida AMP","year":"1987","journal-title":"Rev Bras Microbiol"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1590\/S0074-02761996000200014","article-title":"The use of polyvinyl alcohol glutaraldehyde as solid-phase in ELISA for plague","volume":"91","author":"Araujo AM","year":"1996","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1590\/S0100-879X2000000700013","article-title":"The use of filter paper plasticized with polyvinyl alcohol-glutaraldehyde in ELISA","volume":"33","author":"Barbosa GHTS","year":"2000","journal-title":"Braz J Med Biol Res"},{"issue":"4","key":"ref30","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1590\/S0074-02761991000400016","article-title":"The use of dacron plates for DOT enzyme-linked immunosorbent assay (DOT-ELISA)","volume":"86","author":"Montenegro SML","year":"1991","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1590\/S0074-02761992000100014","article-title":"Evaluation of three serological tests for the detection of human plague in northeast Brazil","volume":"87","author":"Almeida AMP","year":"1992","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1590\/S0074-02761998000100020","article-title":"Rapid Elisa for Plague","volume":"93","author":"Araujo AM","year":"1998","journal-title":"Mem Inst Oswaldo Cruz"},{"issue":"1","key":"ref33","first-page":"42","article-title":"Performance assessment of a new indirect rapid diagnostic test for plague detection in humans and other mammalian hosts","volume":"231","author":"Bezerra MF","year":"2022","journal-title":"Acta Trop"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s10482-024-01949-x","article-title":"Lyophilization for bacteria preservation a promising approach for Yersinia pestis strains from an unique collection in Brazil (Fiocruz-CYP)","volume":"117","author":"Rocha IV","year":"2024","journal-title":"Anton Van Leeuwenhoek"},{"issue":"1","key":"ref35","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1017\/S0950268800029228","article-title":"Identification of encapsulated and non-encapsulated Yersinia pestis by immunofluorescence tests using polyclonal and monoclonal antibodies","volume":"101","author":"Phillips AP","year":"1988","journal-title":"Epidemiol Infect"},{"issue":"8","key":"ref36","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1128\/JCM.00564-21","article-title":"Improved selective BIN agar for a better rate of Yersinia pestis isolation from primary clinical specimens in suspected Madagascar plague cases","volume":"59","author":"Aftalion M","year":"2021","journal-title":"J Clin Microbiol"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.mimet.2010.03.019","article-title":"Selective isolation of Yersinia pestis from plague-infected fleas","volume":"82","author":"Sarovich DS","year":"2010","journal-title":"J Microbiol Methods"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"2653","DOI":"10.1007\/s00253-023-12452-0","article-title":"CYP broth a tool for Yersinia pestis isolation in ancient culture collections and field samples","volume":"107","author":"Rocha IV","year":"2023","journal-title":"Appl Microbiol Biotechnol"},{"issue":"1","key":"ref39","first-page":"122","article-title":"Effective discrimination of Yersinia pestis and Yersinia pseudotuberculosis by MALDI-TOF MS using multivariate analysis","volume":"234","author":"Feng B","year":"2021","journal-title":"Talanta"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1007\/978-0-387-72124-8_32","article-title":"Development and evaluation of a single tube nested PCR based approach (STNPCR) for the diagnosis of plague","volume":"603","author":"Souza G","year":"2007","journal-title":"Adv Exp Med Biol"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"1069","DOI":"10.4236\/ajac.2014.516114","article-title":"The development of a loop-mediated isothermal amplification (LAMP) procedure for plague diagnostic","volume":"05","author":"Lira-Nunes M","year":"2014","journal-title":"Am J Anal Chem"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1590\/S0036-46651999000600002","article-title":"Diagnosis of plague and identification of virulence markers in Yersinia pestis by multiplex-PCR","volume":"41","author":"Leal NC","year":"1999","journal-title":"Rev Inst Med Trop S\u00e3o Paulo"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1002\/mbo3.1105","article-title":"Pentaplex real-time PCR for differential detection of Yersinia pestis and Y pseudotuberculosis and application for testing fleas collected during plague epizootics","volume":"9","author":"Bai Y","year":"2020","journal-title":"Microbiologyopen"},{"issue":"5","key":"ref44","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1371\/journal.pntd.0012167","article-title":"Development and evaluation of a multi-target droplet digital PCR assay for highly sensitive and specific detection of Yersinia pestis","volume":"18","author":"Zhao Y","year":"2024","journal-title":"PLoS Negl Trop Dis"},{"issue":"9","key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3201\/eid3009.240468","article-title":"Ecologic, geoclimatic, and genomic factors modulating plague epidemics in primary natural focus, Brazil","volume":"30","author":"Bezerra MF","year":"2024","journal-title":"Emerg Infect Dis"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0074-02762025000100850&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,2,3]],"date-time":"2025-02-03T11:30:30Z","timestamp":1738582230000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762025000100850&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":45,"alternative-id":["S0074-02762025000100850"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760240220","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e240220"}}