{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:08:54Z","timestamp":1765811334589,"version":"3.48.0"},"reference-count":40,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009730","name":"UFOP","doi-asserted-by":"crossref","award":["APQ-02511-22"],"award-info":[{"award-number":["APQ-02511-22"]}],"id":[{"id":"10.13039\/501100009730","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004901","name":"FAPEMIG","doi-asserted-by":"crossref","award":["APQ-02511-22"],"award-info":[{"award-number":["APQ-02511-22"]}],"id":[{"id":"10.13039\/501100004901","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["APQ-02511-22"],"award-info":[{"award-number":["APQ-02511-22"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100003593","name":"CNPq","doi-asserted-by":"crossref","award":["APQ-02511-22"],"award-info":[{"award-number":["APQ-02511-22"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004809","name":"FINEP","doi-asserted-by":"crossref","award":["APQ-02511-22"],"award-info":[{"award-number":["APQ-02511-22"]}],"id":[{"id":"10.13039\/501100004809","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p>BACKGROUND  Parasitic diseases may increase the risk of metabolic abnormalities through persistent inflammation. However, the effects of a hyperglycaemic diet during Trypanosoma cruzi infection remain poorly understood.  OBJECTIVES  This study aimed to investigate the metabolic, parasitological, immunological, and histological effects of a hyperglycaemic diet during acute T. cruzi infection in mice.  METHODS  C57BL\/6 mice were divided into four groups: non-infected with standard diet (NISD), infected with a standard diet (ISD), non-infected with hyperglycaemic diet (NIHD), and infected with hyperglycaemic diet (IHD). Animals were fed their respective diets for eight weeks prior to infection and monitored up to 30 days post-infection (DPI) for blood glucose, body mass, biochemical markers, parasitaemia, tissue alterations, and immune cell profiles.  FINDINGS  At the time of infection, hyperglycaemic diet groups showed higher blood glucose and body mass. By 30 DPI, these animals exhibited lower glucose, increased parasitaemia, adipose tissue hypertrophy, and reduced cholesterol levels compared with controls. Infected groups showed an increased CD4+ IFN-\u03b3+ T cells at 10 DPI, whereas macrophage expansion was observed only in ISD mice. Cardiac parasitism was higher at 30 DPI than at 10 DPI.  MAIN CONCLUSIONS These results show that T. cruzi infection affects metabolic parameters and that a hyperglycaemic diet worsens parasitological outcomes during the acute phase of infection and appears to downregulate the immune response.<\/jats:p>","DOI":"10.1590\/0074-02760250092","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:04:21Z","timestamp":1765811061000},"source":"Crossref","is-referenced-by-count":0,"title":["Influence of a hyperglycaemic diet on Trypanosoma cruzi infection in mice model"],"prefix":"10.1590","volume":"120","author":[{"given":"Aline Coelho","family":"das Merc\u00eas","sequence":"first","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fl\u00e1via de Souza","family":"Marques","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Teixeira","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriel Jos\u00e9 Lucas","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno Mendes","family":"Roatt","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cl\u00e1udia Martins","family":"Carneiro","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil; Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Silvia de","family":"Paula-Gomes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joana Ferreira","family":"do Amaral","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7033-7686","authenticated-orcid":false,"given":"Paula Melo de Abreu","family":"Vieira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ouro Preto,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","article-title":"Nova tripanozomiaze humana. 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AK","year":"2004","journal-title":"Kinetoplastid Biol Dis"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0074-02762025000101160&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:04:28Z","timestamp":1765811068000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762025000101160&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025]]},"references-count":40,"alternative-id":["S0074-02762025000101160"],"URL":"https:\/\/doi.org\/10.1590\/0074-02760250092","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2025]]},"article-number":"e250092"}}