{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T10:15:17Z","timestamp":1787220917081,"version":"build-2736575974"},"reference-count":51,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100002322","name":"CAPES","doi-asserted-by":"crossref","award":["04\/2022"],"award-info":[{"award-number":["04\/2022"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004916","name":"FAPEAM","doi-asserted-by":"crossref","award":["001"],"award-info":[{"award-number":["001"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100004916","name":"FAPEAM","doi-asserted-by":"crossref","award":["04\/2022"],"award-info":[{"award-number":["04\/2022"]}],"id":[{"id":"10.13039\/501100004916","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p>BACKGROUND  Mosquito-disseminated pyriproxyfen (MD-PPF) is a promising novel tool for urban-mosquito control, yet resistance to PPF (a juvenile-hormone analogue) may arise in exposed mosquito populations. Alternative larvicide\/pupicide molecules suitable for mosquito-driven dissemination, but with distinct modes of action, are therefore needed.  OBJECTIVES  To provide a proof-of-concept evaluation of mosquito-disseminated diflubenzuron (MD-DFB, a chitin-synthesis inhibitor) and spinosad (MD-SPN, a biological neurotoxin composite) as potential alternatives to MD-PPF.  METHODS  We studied Aedes aegypti-driven dissemination in 20 blind, controlled experiments run in 110 \u00d7 90 \u00d7 30-cm cages. Of primary interest was whether and how (a) mosquito-driven dissemination affected adult-mosquito emergence (1705 larvae in 40 open and 20 closed cups set inside cages; generalised linear mixed models) and (b) exposure to larvicide\/pupicide-treated dissemination stations affected adult-female lifespan (400 females released inside cages; proportional-hazards mixed models).  FINDINGS  Adult-mosquito emergence was similar across treatments in closed cups. In open cups, average emergence fell from ~90% [95% confidence interval (CI), 84-95%] in control cages to ~30% (20-43%), ~56% (42-69%), and ~75% (63-85%) in, respectively, MD-PPF, MD-DFB, and MD-SPN cages. Exposure to SPN, but not to DFB or PPF, clearly reduced adult-female lifespan (SPN death-hazard ratio 2.4; 1.2-5.0).  CONCLUSION  Mosquito-disseminated diflubenzuron holds promise as a potential alternative to MD-PPF; further testing in field settings seems warranted.<\/jats:p>","DOI":"10.1590\/0074-02760250160","type":"journal-article","created":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T15:06:39Z","timestamp":1765811199000},"source":"Crossref","is-referenced-by-count":2,"title":["Mosquito-disseminated diflubenzuron and spinosad as alternatives to mosquito-disseminated pyriproxyfen: a proof-of-concept, blind, controlled comparison in experimental cages"],"prefix":"10.1590","volume":"120","author":[{"given":"Gabriela Brandina Aquino","family":"de Abreu","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayrton Sena","family":"Gouveia","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Augusto da Silva","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Joaqu\u00edn","family":"Carvajal-Cort\u00e9s","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cl\u00e1udia Torres","family":"Code\u00e7o","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7715-0328","authenticated-orcid":false,"given":"Fernando","family":"Abad-Franch","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Universidade Federal de Minas Gerais,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5887-7372","authenticated-orcid":false,"given":"S\u00e9rgio Luiz Bessa","family":"Luz","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","series-title":"Global vector control response 2017-2030","year":"2017"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"e302","DOI":"10.1016\/S1473-3099(19)30161-6","article-title":"The effect of global change on mosquito-borne disease","volume":"19","author":"Franklinos LHV","year":"2019","journal-title":"Lancet Infect Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/s40249-017-0288-0","article-title":"The cross-cutting contribution of the end of neglected tropical diseases to the sustainable development 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