{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:17:28Z","timestamp":1787023048565,"version":"build-2736575974"},"reference-count":71,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2021\/06185-9"],"award-info":[{"award-number":["2021\/06185-9"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p>BACKGROUND Amblyomma sculptum is the main vector implicated in the transmission of Rickettsia rickettsii in southeastern Brazil, where capybaras are known to be the main amplifying hosts of this pathogen. Interestingly, many areas inhabited by large populations of capybaras and A. sculptum remain free of R. rickettsii, suggesting that other drivers may be involved in the pathogen perpetuation. A. sculptum frequently occurs in sympatry with Amblyomma dubitatum ticks, sharing the same hosts with them. Considering that A. dubitatum ticks are frequently infected with Rickettsia bellii, a possible interference of R. bellii in the reservoir competence of capybaras for R. rickettsii could explain the heterogeneous distribution of R. rickettsii in A. sculptum populations in southeastern Brazil.  OBJECTIVES The present study aimed to evaluate the effect of primary exposure to R. bellii-infected A. dubitatum on the reservoir competence for R. rickettsii using guinea pigs as experimental models.  METHODS Three guinea pigs were infested with R. bellii-infected A. dubitatum (Group GB), four guinea pigs with uninfected A. dubitatum (Group GD), and three guinea pigs were not exposed to A. dubitatum (Group GC). After infestation with A. dubitatum, all guinea pigs were exposed to one single R. rickettsii-infected A. sculptum female and then were infested with uninfected A. sculptum larvae. After ecdysis, nymphs were tested for detection of spotted fever group rickettsiae.  FINDINGS Five out of six guinea pigs from GD and GC groups died, while one out of three guinea pigs in the GB group had a fatal outcome. R. rickettsii infection rate among ticks fed on animals from GB group was 21% (17\/80), significantly lower than the rate of 54% (60\/111) recorded in ticks fed on animals from GD and GC groups.  MAIN CONCLUSIONS Prior exposure of guinea pigs to R. bellii-infected A. dubitatum ticks reduced their reservoir competence for R. rickettsii.<\/jats:p>","DOI":"10.1590\/0074-02760250195","type":"journal-article","created":{"date-parts":[[2026,3,23]],"date-time":"2026-03-23T11:05:09Z","timestamp":1774263909000},"source":"Crossref","is-referenced-by-count":3,"title":["Effects of exposure to Rickettsia bellii on reservoir competence of guinea pigs for Rickettsia rickettsii"],"prefix":"10.1590","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2136-7149","authenticated-orcid":false,"given":"Lina de Campos","family":"Binder","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos Eduardo Camargo","family":"Fanchini","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Herbert Sousa","family":"Soares","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil; Universidade Santo Amaro,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talita Beck Strabelli dos","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sueli Akemi","family":"Taniwaki","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelly Bastos","family":"Nassar","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Cristina","family":"Foga\u00e7a","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Carolina de Azevedo","family":"Serpa","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matheus Pasini","family":"Martins","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo Bahia","family":"Labruna","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"Suppl. 1","key":"ref1","first-page":"1","article-title":"Febre maculosa brasileira","volume":"8","author":"Pinter A","year":"2011","journal-title":"Bepa"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"54","DOI":"10.57148\/bepa.2021.v.18.37185","article-title":"Informe t\u00e9cnico sobre febre maculosa brasileira","volume":"18","author":"Pinter 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