{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T15:33:18Z","timestamp":1765553598235,"version":"3.48.0"},"reference-count":51,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,1,1]],"date-time":"2025-01-01T00:00:00Z","timestamp":1735689600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p>Malaria was one of the main research themes of Le\u00f4nidas de Mello Deane (1914-1993) and Maria Jos\u00e9 von Paumgartten Deane (1916-1995), a couple of parasitologists - known among their peers as \u201cthe Deanes\u201d - who in the late 1930s and 1940s ventured into areas of the Amazon, where the disease was endemic, and of the northeastern Brazil, where an important epidemic outbreak ecloded. Despite their knowledge of the disease and the adoption of preventive measures, both contracted malaria, he the malignant tertian fever (Plasmodium falciparum) and she the benign form of the disease (Plasmodium vivax). This article describes the circumstances in which they became infected and the evolution and outcome of their malaria. The years subsequent to the period in which they became ill witnessed extraordinary progress in the pharmacological treatment of malaria. The Deanes\u2019 two episodes of malaria are contextualised in relation to the treatment alternatives available at the time and the couple\u2019s suspicions regarding the development of resistance to existing antimalarial drugs in view of the persistence of recurrences of the disease despite treatment.<\/jats:p>","DOI":"10.1590\/0074-02760250232","type":"journal-article","created":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T15:04:44Z","timestamp":1765551884000},"source":"Crossref","is-referenced-by-count":0,"title":["The Deanes\u2019 malarias and the antimalarial drugs in 1939 and the 1940s"],"prefix":"10.1590","volume":"120","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6207-0149","authenticated-orcid":false,"given":"Francisco Jos\u00e9 Roma","family":"Paumgartten","sequence":"first","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cecilia Amado Xavier","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9075-1470","authenticated-orcid":false,"given":"Cl\u00e1udio Tadeu","family":"Daniel-Ribeiro","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Funda\u00e7\u00e3o Oswaldo Cruz-Fiocruz,  Brazil; Minist\u00e9rio da Sa\u00fade,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2025]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20072290","article-title":"Yellow fever and Max Theiler: the only Nobel Prize for a virus vaccine","author":"Norrby E","year":"2007","journal-title":"J Exp Med"},{"key":"ref2","article-title":"The yellow fever vaccine: a history","author":"Frierson JG","year":"2010","journal-title":"Yale J Biol Med"},{"key":"ref3","series-title":"Cr\u00f4nicas subversivas de um cientista","volume-title":"Ex\u00edlio e ci\u00eancia","author":"Silva LHP","year":"2012"},{"key":"ref4","series-title":"Anopheles gambiae in Brazil - 1930 to 1940","author":"Soper FL","year":"1943"},{"key":"ref5","first-page":"212","article-title":"Anopheles gambiae en Brasil In: Andanzas por el Mundo de la Salud. 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