{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T20:51:20Z","timestamp":1792788680605,"version":"4.5.0"},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"BMZ - Bundesministerium f\u00fcr wirtschaftliche Zusammenarbeit und Entwicklung","id":[{"id":"https:\/\/ror.org\/00e0ttj68","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Doctors Without Borders"},{"name":"Takeda Japan"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"abstract":"<jats:p>BACKGROUND In 2017, an estimated 1.2% of the population at risk for Chagas disease (CD) in Colombia was screened, and only 0.4% were treated. The recent implementation of CD-related Care roadmap has improved access to diagnosis and treatment. However, a therapeutic gap (TG) persists.  OBJECTIVES In this work, we aim to analyse the TG for Trypanosoma cruzi\/CD infection in Colombia over the last years.  METHODS This is a descriptive study estimating the TG for T. cruzi\/CD infection between 2012 and 2022. TG is defined as the number of people with a confirmed infection who have the indication of treatment but do not receive it. Two scenarios were considered in the TG analysis: (A) antiparasitic treatment is indicated in 70% of people with confirmed infection; (B) antiparasitic treatment indication in 85%. Data sources were official National and Departmental databases.  FINDINGS In scenario A, the TG was 77.5% in 2012, and by 2022, decreased to 48.1%. Two phases in the TG dynamics were observed: between 2012 and 2014, there was an increase of 4.5%; from 2014 onwards, there was a reduction of 40.7%. The most important reduction of TG was observed in 2018 and 2019. Linear projections from 2014-2022 indicate a potential reduction to 13.7% by 2030. Nevertheless, there are differences in terms of the reduction observed in different departments.  MAIN CONCLUSION TG calculation allows monitoring of treatment coverage, and its analysis facilitates target interventions to improve it, by reducing TG. Implementing interventions aimed at reducing the TG allows countries like Colombia to take a step forward in CD control.<\/jats:p>","DOI":"10.1590\/0074-02760260007","type":"journal-article","created":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T10:57:09Z","timestamp":1791802629000},"source":"Crossref","is-referenced-by-count":0,"title":["Analysis of the therapeutic gap for Trypanosoma cruzi infection in Colombia (2012 - 2022)"],"prefix":"10.1590","volume":"121","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-2900-9024","authenticated-orcid":false,"given":"Rafael","family":"Herazo","sequence":"first","affiliation":[{"name":"Drugs for Neglected Diseases initiative","place":["Rio de Janeiro, RJ, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo Andr\u00e9s","family":"Caicedo D\u00edaz","sequence":"additional","affiliation":[{"name":"Drugs for Neglected Diseases initiative","place":["Rio de Janeiro, RJ, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauricio Javier","family":"Vera Soto","sequence":"additional","affiliation":[{"name":"Ministerio de Salud y Protecci\u00f3n Social","place":["Colombia"]},{"name":"Universidad Aut\u00f3noma de Manizales","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea Liliana","family":"Sarmiento Ospina","sequence":"additional","affiliation":[{"name":"Ministerio de Salud y Protecci\u00f3n Social","place":["Colombia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diogo","family":"Galv\u00e3o","sequence":"additional","affiliation":[{"name":"Drugs for Neglected Diseases initiative","place":["Rio de Janeiro, RJ, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Marchiol","sequence":"additional","affiliation":[{"name":"Drugs for Neglected Diseases initiative","place":["Rio de Janeiro, RJ, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria-Jesus","family":"Pinazo","sequence":"additional","affiliation":[{"name":"Drugs for Neglected Diseases initiative","place":["Rio de Janeiro, RJ, Brazil"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2026]]},"reference":[{"issue":"6","key":"ref1","first-page":"33","article-title":"Chagas disease in Latin America: an epidemiological update based on 2010 estimates","volume":"90","year":"2015","journal-title":"Wkly Epidemiol Rec"},{"key":"ref2","article-title":"Atenci\u00f3n integral de casos de enfermedad de Chagas, poblaciones a riesgo para enfermedad de Chagas y meta de tamizaje de las gestantes para enfermedad de Chagas","year":"2021","journal-title":"Ministerio de Salud y Protecci\u00f3n Social"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"344","DOI":"10.7705\/biomedica.v20i4.1078","article-title":"Distribuci\u00f3n actual e importancia epidemiol\u00f3gica de las especies de triatominos (Reduviidae: Triatominae) en Colombia","volume":"20","author":"Molina JA","year":"2000","journal-title":"Biomedica"},{"key":"ref4","article-title":"Otros 33 municipios de Colombia bloquearon la transmisi\u00f3n de la enfermedad de Chagas","year":"2019","journal-title":"Ministerio de Salud y Protecci\u00f3n Social"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.socscimed.2017.01.002","article-title":"How universal is coverage and access to diagnosis and treatment for Chagas disease in Colombia? 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