{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,14]],"date-time":"2025-10-14T07:00:54Z","timestamp":1760425254642},"reference-count":53,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Mem. Inst. Oswaldo Cruz"],"DOI":"10.1590\/0074-0276140339","type":"journal-article","created":{"date-parts":[[2014,3,31]],"date-time":"2014-03-31T17:11:19Z","timestamp":1396285879000},"page":"174-181","source":"Crossref","is-referenced-by-count":3,"title":["Metallothionein-1 and nitric oxide expression are inversely correlated in a murine model of Chagas disease"],"prefix":"10.1590","volume":"109","author":[{"given":"Martha Elba","family":"Gonzalez-Mejia","sequence":"first","affiliation":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Enrique","family":"Torres-Rasgado","sequence":"additional","affiliation":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo M","family":"Porchia","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hilda Rosas","family":"Salgado","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9-Luis","family":"Totolhua","sequence":"additional","affiliation":[{"name":"Instituto Mexicano del Seguro Social, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arturo","family":"Ortega","sequence":"additional","affiliation":[{"name":"Unidad Zacatenco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa Clara Regina","family":"Hern\u00e1ndez-Kelly","sequence":"additional","affiliation":[{"name":"Unidad Zacatenco, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guadalupe","family":"Ruiz-Vivanco","sequence":"additional","affiliation":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca G","family":"B\u00e1ez-Duarte","sequence":"additional","affiliation":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"P\u00e9rez-Fuentes","sequence":"additional","affiliation":[{"name":"Benem\u00e9rita Universidad Aut\u00f3noma de Puebla, M\u00e9xico; Instituto Mexicano del Seguro Social, M\u00e9xico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2014,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1590\/S0074-02761986000100004","article-title":"Chronic murine myocarditis due to Trypanosoma cruzi - an ultrastructural study and immunochemical characterization of cardiac interstitial matrix","volume":"81","author":"Andrade SG","year":"1986","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref2","first-page":"49","article-title":"Nitric oxide mediated metallothionein induction by lipopolysaccharide","volume":"90","author":"Arizono K","year":"1995","journal-title":"Res Commun Mol Pathol Pharmacol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1042\/BJ20111565","article-title":"Metallothioneins protect cytosolic creatine kinases against stress induced by nitrogen-based oxidants","volume":"441","author":"Chen Z","year":"2012","journal-title":"Biochem J"},{"key":"ref4","series-title":"International guiding principles for biomedical research involving animals","year":"2012"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1590\/S0074-02762012000200010","article-title":"Acute experimental Trypanosoma cruzi infection: establishing a murine model that utilises non-invasive measurements of disease parameters","volume":"107","author":"da Silva DR","year":"2012","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref6","first-page":"295","article-title":"Laboratory animals and official Mexican Norms (NOM-062-ZOO-1999)","volume":"138","author":"de Aluja AS","year":"2002","journal-title":"Gac Med Mex"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1006\/expr.2000.4552","article-title":"Trypanosoma cruzi: infectivity of clonal genotype infections in acute and chronic phases in mice","volume":"96","author":"de Lana M","year":"2000","journal-title":"Exp Parasitol"},{"key":"ref8","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/890672","article-title":"Mexican Trypanosoma cruzi. T. cruzi I strains with different degrees of virulence induce diverse humoral and cellular immune responses in a murine experimental infection model","volume":"2010","author":"Espinoza B","year":"2010","journal-title":"J Biomed Biotechnol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1128\/IAI.72.1.359-363.2004","article-title":"Intracellular growth of Trypanosoma cruzi in cardiac myocytes is inhibited by cytokine-induced nitric oxide release","volume":"72","author":"Fichera LE","year":"2004","journal-title":"Infect Immun"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"684","DOI":"10.1590\/S0037-86822011005000058","article-title":"Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model","volume":"44","author":"G\u00f3mez-Hern\u00e1ndez C","year":"2011","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0003-2697(82)90118-X","article-title":"Analysis of nitrate, nitrite and [15N] nitrate in biological fluids","volume":"126","author":"Green LC","year":"1982","journal-title":"Anal Biochem"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"152","DOI":"10.4269\/ajtmh.2001.65.152","article-title":"Mouse model for Chagas disease: immunohistochemical distribution of different stages of Trypanosoma cruzi in tissues throughout infection","volume":"65","author":"Guarner J","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1111\/j.1476-5381.2009.00576.x","article-title":"Nitric oxide donor trans-[RuCl([15]aneN)NO] as a possible therapeutic approach for Chagas disease","volume":"160","author":"Guedes PM","year":"2010","journal-title":"Br J Pharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1017\/S0031182000066889","article-title":"A quick, simple method for purifying Leishmania mexicana amastigotes in large numbers","volume":"82","author":"Hart DT","year":"1981","journal-title":"Parasitology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1006\/cyto.1999.0629","article-title":"Metallothionein induction by restraint stress: role of glucocorticoids and IL-6","volume":"12","author":"Hern\u00e1ndez J","year":"2000","journal-title":"Cytokine"},{"key":"ref16","doi-asserted-by":"crossref","DOI":"10.1155\/2009\/101659","article-title":"Metallothionein as an anti-inflammatory mediator","volume":"2009","author":"Inoue K","year":"2009","journal-title":"Mediators Inflamm"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1046\/j.1365-2249.1998.00637.x","article-title":"IL-10 up-regulates nitric oxide (NO) synthesis by lipopolysaccharide (LPS)-activated macrophages: improved control of Trypanosoma cruzi infection","volume":"113","author":"Jacobs F","year":"1998","journal-title":"Clin Exp Immunol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1046\/j.1365-2249.1996.d01-632.x","article-title":"Administration of anti-CD3 monoclonal antibody during experimental Chagas disease induces CD8+ cell-dependent lethal shock","volume":"103","author":"Jacobs F","year":"1996","journal-title":"Clin Exp Immunol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1128\/MMBR.59.4.533-547.1995","article-title":"Role of nitric oxide in parasitic infections","volume":"59","author":"James SL","year":"1995","journal-title":"Microbiol Rev"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1459","DOI":"10.1177\/153537020623100903","article-title":"Metallothionein redox cycle and function","volume":"231","author":"Kang YJ","year":"2006","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/S0378-4274(00)00301-5","article-title":"Nitric oxide induces metallothionein (MT) gene expression apparently by displacing zinc bound to MT","volume":"119","author":"Katakai K","year":"2001","journal-title":"Toxicol Lett"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1055\/s-2005-864185","article-title":"Involvement of cytokines in the hepatic metallothionein expression by alpha-hederin","volume":"71","author":"Kim JY","year":"2005","journal-title":"Planta Med"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1859","DOI":"10.1248\/bpb.28.1859","article-title":"Induction of hepatic metallothionein by trivalent cerium: role of interleukin-6","volume":"28","author":"Kobayashi K","year":"2005","journal-title":"Biol Pharm Bull"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1515\/BC.2011.199","article-title":"Ammonia increases nitric oxide, free Zn(2+) and metallothionein mRNA expression in cultured rat astrocytes","volume":"392","author":"Kruczek C","year":"2011","journal-title":"Biol Chem"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0041-008X(91)90171-A","article-title":"Endotoxin induction of hepatic metallothionein is mediated through cytokines","volume":"109","author":"Liu J","year":"1991","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"10265","DOI":"10.1158\/0008-5472.CAN-10-2839","article-title":"Loss of metallothionein predisposes mice to diethylnitrosamine-induced hepatocarcinogenesis by activating NF-kappaB target genes","volume":"70","author":"Majumder S","year":"2010","journal-title":"Cancer Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.micinf.2009.07.011","article-title":"Infection by the Sylvio X10\/4 clone of Trypanosoma cruzi: relevance of a low-virulence model of Chagas disease","volume":"11","author":"Marinho CR","year":"2009","journal-title":"Microbes Infect"},{"key":"ref28","first-page":"143","article-title":"Morfometria de tripomastigotas sangu\u00edneos de Trypanosoma cruzi Chagas, 1909 (Kinetoplastidae, Trypanosomatidae)","volume":"37","author":"Martins LA","year":"2008","journal-title":"Rev Patol Reg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1016\/0006-291X(81)90885-8","article-title":"Cloning and sequencing of cDNA for mouse liver metallothionein-I","volume":"103","author":"Mbikay M","year":"1981","journal-title":"Biochem Biophys Res Commun"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"475","DOI":"10.2307\/3279787","article-title":"Tissue tropism of different Trypanosoma cruzi strains","volume":"64","author":"Melo RC","year":"1978","journal-title":"J Parasitol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1080\/10409230091169168","article-title":"Induction, regulation, degradation and biological significance of mammalian metallothioneins","volume":"35","author":"Miles AT","year":"2000","journal-title":"Crit Rev Biochem Mol Biol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1006\/expr.1999.4472","article-title":"Trypanosoma cruzi: the effect of nitric oxide synthesis inhibition on the CD4 T cell response to the trans-sialidase superfamily","volume":"94","author":"Millar AE","year":"2000","journal-title":"Exp Parasitol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/S0197-0186(98)00065-5","article-title":"Effect of nitric oxide synthesis inhibition on mouse liver and brain metallothionein expression","volume":"33","author":"Molinero A","year":"1998","journal-title":"Neurochem Int"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1002\/immu.200390009","article-title":"Concerted action of perforin and granzymes is critical for the elimination of Trypanosoma cruzi from mouse tissues, but prevention of early host death is in addition dependent on the FasL\/Fas pathway","volume":"33","author":"M\u00fcller U","year":"2003","journal-title":"Eur J Immunol"},{"key":"ref35","first-page":"133","article-title":"Nitro-L-arginine inteferes with the cadmium reduction of nitrate\/griess reaction method of measuring nitric oxide production","volume":"34","author":"Nithipatikom K","year":"1996","journal-title":"Eur J Clin Chem Clin Biochem"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1002\/dmrr.1254","article-title":"The combination of metallothionein and superoxide dismutase protects pancreatic beta cells from oxidative damage","volume":"27","author":"Park L","year":"2011","journal-title":"Diabetes Metab Res Rev"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/S0020-7519(02)00283-7","article-title":"Severity of chronic Chagas disease is associated with cytokine\/antioxidant imbalance in chronically infected individuals","volume":"33","author":"P\u00e9rez-Fuentes R","year":"2003","journal-title":"Int J Parasitol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1179\/136485907X154593","article-title":"Correlation of the serum concentrations of tumour necrosis factor and nitric oxide with disease severity in chronic Chagas disease (American trypanosomiasis)","volume":"101","author":"P\u00e9rez-Fuentes R","year":"2007","journal-title":"Ann Trop Med Parasitol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"715","DOI":"10.4269\/ajtmh.1998.58.715","article-title":"Humoral nitric oxide levels and antibody immune response of symptomatic and indeterminate Chagas disease patients to commercial and autochthonous Trypanosoma cruzi antigen","volume":"58","author":"P\u00e9rez-Fuentes R","year":"1998","journal-title":"Am J Trop Med Hyg"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1179\/136485908X267858","article-title":"The anti-oxidant defence response in individuals with the indeterminate form of Chagas disease (American trypanosomiasis)","volume":"102","author":"P\u00e9rez-Fuentes R","year":"2008","journal-title":"Ann Trop Med Parasitol"},{"key":"ref41","series-title":"Metallothioneins and related chelators","first-page":"353","volume-title":"Metallothionein toxicology: metal ion trafficking and cellular protection","volume":"5","author":"Petering D","year":"2009"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1016\/0165-2478(95)00083-H","article-title":"Role of nitric oxide in resistance and histopathology during experimental infection with Trypanosoma cruzi","volume":"47","author":"Petray P","year":"1995","journal-title":"Immunol Lett"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1388","DOI":"10.1016\/S0140-6736(10)60061-X","article-title":"Chagas disease","volume":"375","author":"Rassi A","year":"2010","journal-title":"Lancet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1590\/S0074-02762006000600002","article-title":"Trypanosoma cruzi strains isolated from human, vector and animal reservoir in the same endemic region in Mexico and typed as T. cruzi I, discrete typing unit 1 exhibit considerable biological diversity","volume":"101","author":"S\u00e1nchez-Guill\u00e9n MC","year":"2006","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref45","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0000578","article-title":"The liver plays a major role in clearance and destruction of blood trypomastigotes in Trypanosoma cruzi chronically infected mice","volume":"4","author":"Sardinha LR","year":"2010","journal-title":"PLoS Negl Trop Dis"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1080\/01926230390226069","article-title":"The expression and significance of metallothioneins in murine organs and tissues following mercury vapour exposure","volume":"31","author":"Stankovic RK","year":"2003","journal-title":"Toxicol Pathol"},{"key":"ref47","doi-asserted-by":"crossref","DOI":"10.1186\/1477-7819-9-54","article-title":"A review of metallothionein isoforms and their role in pathophysiology","volume":"9","author":"Thirumoorthy N","year":"2011","journal-title":"World J Surg Oncol"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/0167-4838(85)90098-6","article-title":"Possible role for metallothionein in protection against radiation-induced oxidative stress. Kinetics and mechanism of its reaction with superoxide and hydroxyl radicals","volume":"827","author":"Thornalley PJ","year":"1985","journal-title":"Biochim Biophys Acta"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.2307\/3284671","article-title":"One fate of epimastigote forms of Trypanosoma cruzi injected in mice. An ultrastructural study","volume":"84","author":"Umekita LF","year":"1998","journal-title":"J Parasitol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1007\/s00775-011-0799-2","article-title":"Chemistry and biology of mammalian metallothioneins","volume":"16","author":"Vasak M","year":"2011","journal-title":"J Biol Inorg Chem"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"5177","DOI":"10.1128\/IAI.62.11.5177-5182.1994","article-title":"Nitric oxide is involved in control of Trypanosoma cruzi-induced parasitemia and directly kills the parasite in vitro","volume":"62","author":"Vespa GN","year":"1994","journal-title":"Infect Immun"},{"key":"ref52","first-page":"407","article-title":"Antioxidant role of metallothioneins: a comparative overview","volume":"46","author":"Viarengo A","year":"2000","journal-title":"Cell Mol Biol (Noisy-le-grand)"},{"key":"ref53","series-title":"Chagas disease (American trypanosomiasis)","year":"2013"}],"container-title":["Mem\u00f3rias do Instituto Oswaldo Cruz"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/mioc\/v109n2\/0074-0276-mioc-0074-0276140339.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,8,17]],"date-time":"2020-08-17T02:00:17Z","timestamp":1597629617000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0074-02762014000200174&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":53,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2014,4]]}},"alternative-id":["S0074-02762014000200174"],"URL":"https:\/\/doi.org\/10.1590\/0074-0276140339","relation":{},"ISSN":["1678-8060","0074-0276"],"issn-type":[{"value":"1678-8060","type":"electronic"},{"value":"0074-0276","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]}}}