{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,27]],"date-time":"2025-11-27T02:52:29Z","timestamp":1764211949134},"reference-count":8,"publisher":"FapUNIFESP (SciELO)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"published-print":{"date-parts":[[2016,4]]},"abstract":"<jats:p>Abstract Hypersensitivity pneumonitis is a diffuse interstitial and granulomatous lung disease caused by the inhalation of any one of a number of antigens. The objective of this study was to illustrate the spectrum of abnormalities in high-resolution computed tomography and histopathological findings related to hypersensitivity pneumonitis. We retrospectively evaluated patients who had been diagnosed with hypersensitivity pneumonitis (on the basis of clinical-radiological or clinical-radiological-pathological correlations) and had undergone lung biopsy. Hypersensitivity pneumonitis is clinically divided into acute, subacute, and chronic forms; high-resolution computed tomography findings correlate with the time of exposure; and the two occasionally overlap. In the subacute form, centrilobular micronodules, ground-glass opacities, and air trapping are characteristic high-resolution computed tomography findings, whereas histopathology shows lymphocytic inflammatory infiltrates, bronchiolitis, variable degrees of organizing pneumonia, and giant cells. In the chronic form, high-resolution computed tomography shows traction bronchiectasis, honeycombing, and lung fibrosis, the last also being seen in the biopsy sample. A definitive diagnosis of hypersensitivity pneumonitis can be made only through a multidisciplinary approach, by correlating clinical findings, exposure history, high-resolution computed tomography findings, and lung biopsy findings.<\/jats:p>","DOI":"10.1590\/0100-3984.2014.0062","type":"journal-article","created":{"date-parts":[[2016,5,4]],"date-time":"2016-05-04T23:32:53Z","timestamp":1462404773000},"page":"112-116","source":"Crossref","is-referenced-by-count":17,"title":["High-resolution computed tomography and histopathological findings in hypersensitivity pneumonitis: a pictorial essay"],"prefix":"10.1590","volume":"49","author":[{"given":"Pedro Paulo Teixeira e Silva","family":"Torres","sequence":"first","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marise Amaral Rebou\u00e7as","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela Graner Schuwartz Tannus","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta Rodrigues Monteiro da","family":"Gama","sequence":"additional","affiliation":[{"name":"Hospital do C\u00e2ncer de Barretos, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis Masashi","family":"Sugita","sequence":"additional","affiliation":[{"name":"An\u00e1polis Unievang\u00e9lica, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Auxiliadora do Carmo","family":"Moreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Goi\u00e1s, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1921","DOI":"10.1148\/rg.297095707","article-title":"Hypersensitivity pneumonitis: a historical, clinical, and radiologic review","volume":"29","author":"Hirschmann JV","year":"2009","journal-title":"Radiographics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.2214\/AJR.05.1826","article-title":"Hypersensitivity pneumonitis: spectrum of high-resolution CT and pathologic findings","volume":"188","author":"Silva CIS","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1097\/00005382-200210000-00003","article-title":"Clinical and radiologic manifestations of hypersensitivity pneumonitis","volume":"17","author":"Glazer CS","year":"2002","journal-title":"J Thorac 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nonspecific interstitial pneumonia by using thin-section CT","volume":"246","author":"Silva CIS","year":"2008","journal-title":"Radiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1148\/radiol.2442060640","article-title":"Chronic hypersensitivity pneumonitis: CT features comparison with pathologic evidence of fibrosis and survival","volume":"244","author":"Sahin H","year":"2007","journal-title":"Radiology"}],"container-title":["Radiologia 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