{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:37:56Z","timestamp":1775043476142,"version":"3.50.1"},"reference-count":27,"publisher":"FapUNIFESP (SciELO)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract Objective: To evaluate the association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC). Materials and Methods: The patients were evaluated by ultrasonography-guided fine needle aspiration cytology. Typical cytopathological aspects and\/or classical histopathological findings were taken into consideration in the diagnosis of HT, and only histopathological results were considered in the diagnosis of PTC. Results: Among 1,049 patients with multi- or uninodular goiter (903 women and 146 men), 173 (16.5%) had cytopathological features of thyroiditis. Thirty-three (67.4%) out of the 49 operated patients had PTC, 9 (27.3%) of them with histopathological features of HT. Five (31.3%) out of the 16 patients with non-malignant disease also had HT. In the groups with HT, PTC, and PCT+HT, the female prevalence rate was 100%, 91.6%, and 77.8%, respectively. Mean age was 41.5, 43.3, and 48.5 years, respectively. No association was observed between the two diseases in the present study where HT occurred in 31.1% of the benign cases and in 27.3% of malignant cases (p = 0.8). Conclusion: In spite of the absence of association between HT and PCT, the possibility of malignancy in HT should always be considered because of the coexistence of the two diseases already reported in the literature.<\/jats:p>","DOI":"10.1590\/0100-3984.2014.0072","type":"journal-article","created":{"date-parts":[[2015,7,8]],"date-time":"2015-07-08T19:34:02Z","timestamp":1436384042000},"page":"148-153","source":"Crossref","is-referenced-by-count":13,"title":["Is there any association between Hashimoto\u2019s thyroiditis and thyroid cancer? A retrospective data analysis"],"prefix":"10.1590","volume":"48","author":[{"given":"Daysi Maria de","family":"Alc\u00e2ntara-Jones","sequence":"first","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tania Freitas de","family":"Alc\u00e2ntara-Nunes","sequence":"additional","affiliation":[{"name":"Universidade Salvador,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno de Oliveira","family":"Rocha","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rafael Daltro de","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan Chastinet Pitangueira","family":"Santana","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fernanda Tavares de","family":"Alc\u00e2ntara","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thais Magalh\u00e3es de","family":"Faria","sequence":"additional","affiliation":[{"name":"Escola Bahiana de Medicina e Sa\u00fade P\u00fablica,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Campos da","family":"Silva","sequence":"additional","affiliation":[{"name":"Hospital S\u00e3o Rafael,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leila Maria Batista","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2015,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/jc.2013-2409","article-title":"The incidence and prevalence of thyroid dysfunction in Europe: a meta-analysis","volume":"99","author":"Garmendia Madariaga A","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1481","DOI":"10.1016\/j.jpeds.2014.01.059","article-title":"Increase in the incidence of differentiated thyroid carcinoma in children, adolescents, and young adults: a population-based study","volume":"164","author":"Vergamini LB","year":"2014","journal-title":"J Pediatr"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1056\/NEJM199302253280807","article-title":"Management of a solitary thyroid nodule","volume":"328","author":"Mazzaferri EL","year":"1993","journal-title":"N Engl J Med"},{"key":"ref4","series-title":"Valor diagn\u00f3stico da bi\u00f3psia da tire\u00f3ide. Estudo comparativo","author":"Alc\u00e2ntara DMF","year":"1985"},{"key":"ref5","author":"Alc\u00e2ntara-Jones DM"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1001\/archsurg.1955.01270080137023","article-title":"Relation of thyroid neoplasms to Hashimoto disease of the thyroid gland","volume":"70","author":"Dailey ME","year":"1955","journal-title":"Arch Surg"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1210\/jcem.84.2.5443","article-title":"Influence of lymphocytic thyroiditis on the prognostic outcome of patients with papillary thyroid carcinoma","volume":"84","author":"Loh KC","year":"1999","journal-title":"J Clin Endocrinol Metab"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1210\/jc.2012-2978","article-title":"Clinical review: Hashimoto's thyroiditis and papillary thyroid carcinoma: is there a correlation?","volume":"98","author":"Jankovic B","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1288\/00005537-198601000-00015","article-title":"Autoimmune thyroiditis: pathophysiology and relationship to thyroid cancer","volume":"96","author":"Maceri DR","year":"1986","journal-title":"Laryngoscope"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1089\/thy.2009.0450","article-title":"Hashimoto's thyroiditis is not associated with increased risk of thyroid cancer in patients with thyroid nodules: a single-center prospective study","volume":"20","author":"Anil C","year":"2010","journal-title":"Thyroid"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1148\/rg.287085033","article-title":"US-guided fine-needle aspiration of thyroid nodules: indications, techniques, results","volume":"28","author":"Kim MJ","year":"2008","journal-title":"Radiographics"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1089\/thy.2009.0110","article-title":"Revised American Thyroid Association Management Guidelines for patients with thyroid nodules and differentiated thyroid cancer","volume":"19","author":"Cooper DS","year":"2009","journal-title":"Thyroid"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1148\/radiol.2373050220","article-title":"Management of thyroid nodules detected at US: Society of Radiologists in Ultrasound consensus conference statement","volume":"237","author":"Frates MC","year":"2005","journal-title":"Radiology"},{"key":"ref14","series-title":"Guide to clinical aspiration biopsy: thyroid","first-page":"13","volume-title":"Adequacy, reporting system, and cytopreparatory technique","author":"Kini SR","year":"1996","edition":"2nd ed"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"2312","DOI":"10.1002\/1097-0142(19951201)76:11<2312::AID-CNCR2820761120>3.0.CO;2-H","article-title":"Association of chronic lymphocytic thyroiditis and thyroid papillary carcinoma. A study of surgical cases among Japanese, and white and African Americans","volume":"76","author":"Okayasu I","year":"1995","journal-title":"Cancer"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"77","DOI":"10.5935\/1808-8694.20120037","article-title":"Thyroid pappilary carcinoma associated to Hashimoto's thyroiditis","volume":"78","author":"Campos LA","year":"2012","journal-title":"Braz J Otorhinolaryngol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"312","DOI":"10.14310\/horm.2002.1282","article-title":"Coexistence of Hashimoto's thyroiditis with papillary thyroid carcinoma. A retrospective study","volume":"9","author":"Mazokopakis EE","year":"2010","journal-title":"Hormones"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/j.jamcollsurg.2006.12.037","article-title":"Incresed incidence of well-differentiated thyroid cancer associated with Hashimoto thyroiditis and the role of the PI3k\/Akt pathway","volume":"204","author":"Larson SD","year":"2007","journal-title":"J Am Coll Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1210\/jc.2006-0240","article-title":"RET\/papillary thyroid cancer rearrangement in nonneoplastic thyrocytes: follicular cells of Hashimoto's thyroiditis share low-level recombination events with a subset of papillary carcinoma","volume":"91","author":"Rhoden KJ","year":"2006","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1001\/archoto.2010.20","article-title":"Genetic alterations in papillary thyroid carcinoma and Hashimoto thyroiditis: an analysis of hOGG1 loss of heterozygosity","volume":"136","author":"Royer MC","year":"2010","journal-title":"Arch Otolaryngol Head Neck Surg"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"2409","DOI":"10.1210\/jc.2013-1309","article-title":"Differentiated thyroid cancer is associated with less aggressive disease and better outcome in patients with coexisting Hashimoto thyroiditis","volume":"98","author":"Dvorkin S","year":"2013","journal-title":"J Clin Endocrinol Metab"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1089\/thy.2009.0155","article-title":"The Bethesda thyroid fine-needle aspiration classification system: year 1 at an academic institution","volume":"19","author":"Theoharis CG","year":"2009","journal-title":"Thyroid"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"510","DOI":"10.1210\/jc.2013-3160","article-title":"Determination of the optimal time interval for repeat evaluation after a benign thyroid nodule aspiration","volume":"99","author":"Nou E","year":"2014","journal-title":"J Clin Endocrinol Metab"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"993","DOI":"10.1089\/thy.2010.0458","article-title":"The diagnostic accuracy of ultrasound-guided fine-needle aspiration biopsy and the sonographic differences between benign and malignant thyroid nodules 3 cm or larger","volume":"21","author":"Yoon JH","year":"2011","journal-title":"Thyroid"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1016\/j.surg.2011.09.006","article-title":"The impact of atypia\/follicular lesion of undetermined significance on the rate of malignancy in thyroid fine-needle aspiration: evaluation of the Bethesda System for Reporting Thyroid Cytopathology","volume":"150","author":"Broome JT","year":"2011","journal-title":"Surgery"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jss.2011.02.048","article-title":"Fine needle aspiration of the thyroid: a contemporary experience of 3981 cases","volume":"170","author":"Coorough N","year":"2011","journal-title":"J Surg Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1089\/thy.2008.0403","article-title":"Medullary thyroid cancer: management guidelines of the American Thyroid Association","volume":"19","author":"Kloos RT","year":"2009","journal-title":"Thyroid"}],"container-title":["Radiologia Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rb\/v48n3\/0100-3984-rb-48-03-0148.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,3,5]],"date-time":"2018-03-05T19:07:40Z","timestamp":1520276860000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842015000300006&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,6]]},"references-count":27,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2015,6]]}},"alternative-id":["S0100-39842015000300006"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2014.0072","relation":{},"ISSN":["1678-7099","0100-3984"],"issn-type":[{"value":"1678-7099","type":"electronic"},{"value":"0100-3984","type":"print"}],"subject":[],"published":{"date-parts":[[2015,6]]}}}