{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T22:13:21Z","timestamp":1792016001170,"version":"4.4.0"},"reference-count":49,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2015,8,1]],"date-time":"2015-08-01T00:00:00Z","timestamp":1438387200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract Objective: The present study was aimed at retrospectively reviewing high-resolution computed tomography (HRCT) findings in patients with pulmonary alveolar microlithiasis in order to evaluate the frequency of tomographic findings and their distribution in the lung parenchyma. Materials and Methods: Thirteen patients (9 females and 4 males; age, 9 to 59 years; mean age, 34.5 years) were included in the present study. The HRCT images were independently evaluated by two observers whose decisions were made by consensus. The inclusion criterion was the presence of abnormalities typical of pulmonary alveolar microlithiasis at HRCT, which precludes lung biopsy. However, in 6 cases lung biopsy was performed. Results: Ground-glass opacities and small parenchymal nodules were the predominant tomographic findings, present in 100% of cases, followed by small subpleural nodules (92.3%), subpleural cysts (84.6%), subpleural linear calcifications (69.2%), crazy-paving pattern (69.2%), fissure nodularity (53.8%), calcification along interlobular septa (46.2%) and dense consolidation (46.2%). Conclusion: As regards distribution of the lesions, there was preferential involvement of the lower third of the lungs. No predominance of distribution in axial and anteroposterior directions was observed.<\/jats:p>","DOI":"10.1590\/0100-3984.2014.0123","type":"journal-article","created":{"date-parts":[[2015,9,16]],"date-time":"2015-09-16T23:07:16Z","timestamp":1442444836000},"page":"205-210","source":"Crossref","is-referenced-by-count":25,"title":["Can chest high-resolution computed tomography findings diagnose pulmonary alveolar microlithiasis?"],"prefix":"10.1590","volume":"48","author":[{"given":"Fl\u00e1via Ang\u00e9lica Ferreira","family":"Francisco","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosana Souza","family":"Rodrigues","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam Menna","family":"Barreto","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dante Luiz","family":"Escuissato","sequence":"additional","affiliation":[{"name":"Universidade Federal do Paran\u00e1, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Augusto","family":"Araujo Neto","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Luiz Pereira e","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal da Bahia, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudio S.","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidad del Desarrollo Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Hochhegger","sequence":"additional","affiliation":[{"name":"Universidade Federal de Ci\u00eancias da Sa\u00fade de Porto Alegre, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arthur Soares","family":"Souza Jr.","sequence":"additional","affiliation":[{"name":"Faculdade de Medicina de S\u00e3o Jos\u00e9 do Rio Preto, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gl\u00e1ucia","family":"Zanetti","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edson","family":"Marchiori","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2015,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1159\/000074218","article-title":"Pulmonary alveolar microlithiasis. World cases and review of the literature","volume":"70","author":"Castellana G","year":"2003","journal-title":"Respiration"},{"key":"ref2","first-page":"173","article-title":"Pulmonary alveolar microlithiasis: report on 576 cases published in the literature","volume":"21","author":"Mariotta S","year":"2004","journal-title":"Sarcoidosis Vasc Diffuse Lung Dis"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1164\/rccm.200609-1274OC","article-title":"Mutations in the SLC34A2 gene are associated with pulmonary alveolar microlithiasis","volume":"175","author":"Huqun","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1148\/radiol.2462070712","article-title":"Fleischner Society: glossary of terms for thoracic imaging","volume":"246","author":"Hansell DM","year":"2008","journal-title":"Radiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1590\/S0100-39842002000200016","article-title":"Terminologia para a descri\u00e7\u00e3o de tomografia computadorizada do t\u00f3rax (sugest\u00f5es iniciais para um consenso brasileiro)","volume":"35","author":"Souza Jr AS","year":"2002","journal-title":"Radiol Bras"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1590\/S1806-37132005000200011","article-title":"Consenso Brasileiro sobre Terminologia dos Descritores de Tomografia Computadorizada do T\u00f3rax","volume":"32","author":"Pereira-Silva JL","year":"2005","journal-title":"J Bras Pneumol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1590\/S1806-37132010000100016","article-title":"Consenso brasileiro ilustrado sobre a terminologia dos descritores e padr\u00f5es fundamentais da TC de t\u00f3rax","volume":"36","author":"Silva CIS","year":"2010","journal-title":"J Bras Pneumol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1590\/S0100-39842013000500006","article-title":"Computed tomography findings in patients with H1N1 influenza A infection","volume":"46","author":"Amorim VB","year":"2013","journal-title":"Radiol Bras"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1590\/S0100-39842013000300011","article-title":"Rendu-Osler-Weber syndrome: what radiologists should know. Literature review and three cases report","volume":"46","author":"Agnollitto PM","year":"2013","journal-title":"Radiol Bras"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1590\/S0100-39842013000600003","article-title":"Classification of chronic obstructive pulmonary disease based on chest radiography","volume":"46","author":"Marcos L","year":"2013","journal-title":"Radiol Bras"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1590\/S0100-39842013000100008","article-title":"Endobronchial valves in severe emphysematous patients: CT evaluation of lung fissures completeness, treatment radiological response and quantitative emphysema analysis","volume":"46","author":"Koenigkam-Santos M","year":"2013","journal-title":"Radiol Bras"},{"key":"ref12","first-page":"198","article-title":"2-[18F]-fluoro-2-deoxy- D-glucose positron-emission tomography is cost-effective in the initial staging of non-small cell lung cancer patients in Brazil","volume":"45","author":"Cerci JJ","year":"2012","journal-title":"Radiol Bras"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1590\/S0100-39842012000500013","article-title":"Spontaneous regression of pulmonary alveolar proteinosis: a case report","volume":"45","author":"Canellas R","year":"2012","journal-title":"Radiol Bras"},{"key":"ref14","first-page":"191","article-title":"Neuroendocrine tumors of the lung: major radiologic findings in a series of 22 histopathologically confirmed cases","volume":"45","author":"Koenigkam-Santos M","year":"2012","journal-title":"Radiol Bras"},{"issue":"1","key":"ref15","first-page":"xi","article-title":"Pulmonary paracoccidioidomycosis","volume":"47","author":"Zanetti G","year":"2014","journal-title":"Radiol Bras"},{"issue":"3","key":"ref16","first-page":"xi","article-title":"Rhodococcus equi pneumonia in an AIDS patient","volume":"47","author":"Fernandes MC","year":"2014","journal-title":"Radiol Bras"},{"issue":"2","key":"ref17","first-page":"xi","article-title":"Williams-Campbell syndrome","volume":"47","author":"Man\u00e7ano AD","year":"2014","journal-title":"Radiol Bras"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1590\/S0100-39842014000100019","article-title":"Pulmonary tuberculosis in a patient with rheumatoid arthritis undergoing immunosuppressive treatment: case report","volume":"47","author":"Ceratti S","year":"2014","journal-title":"Radiol Bras"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1179\/146532809X402042","article-title":"Pulmonary alveolar microlithiasis in an 8- month-old infant","volume":"29","author":"Dahabreh M","year":"2009","journal-title":"Ann Trop Paediatr"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"221","DOI":"10.5005\/ijcdas-53-4-221","article-title":"Bone scintigraphy in pulmonary alveolar microlithiasis","volume":"53","author":"Shah M","year":"2011","journal-title":"Indian J Chest Dis Allied Sci"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1016\/S0954-6111(03)00140-9","article-title":"Pulmonary alveolar microlithiasis: an overview of clinical and pathological features together with possible therapies","volume":"97","author":"Lauta VM","year":"2003","journal-title":"Respir Med"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1093\/ejcts\/ezt531","article-title":"Right single-lung transplantation for pulmonary alveolar microlithiasis","volume":"45","author":"Borrelli R","year":"2014","journal-title":"Eur J Cardiothorac Surg"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"981","DOI":"10.2214\/ajr.158.5.1566701","article-title":"Pulmonary alveolar microlithiasis: findings on high-resolution CT","volume":"158","author":"Korn MA","year":"1992","journal-title":"AJR Am J Roentgenol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1097\/MCP.0b013e32832d03bb","article-title":"Pulmonary alveolar microlithiasis: review and management","volume":"15","author":"Tachibana T","year":"2009","journal-title":"Curr Opin Pulm Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1159\/000050494","article-title":"Pulmonary alveolar microlithiasis: a rare familial inheritance with report of six cases in a family. Contribution of six new cases to the number of case reports in Turkey","volume":"68","author":"Senyigit A","year":"2001","journal-title":"Respiration"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1002\/(SICI)1099-0496(199601)21:1<62::AID-PPUL11>3.0.CO;2-B","article-title":"Pulmonary alveolar microlithiasis in childhood: diagnosis by transbronchial biopsy","volume":"21","author":"Wallis C","year":"1996","journal-title":"Pediatr Pulmonol"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1159\/000325688","article-title":"Familial pulmonary alveolar microlithiasis diagnosed by bronchoalveolar lavage. A case report","volume":"51","author":"Monabati A","year":"2007","journal-title":"Acta Cytol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"63","DOI":"10.2214\/ajr.168.1.8976922","article-title":"Pulmonary alveolar microlithiasis in children: radiographic and high-resolution CT findings","volume":"168","author":"Helbich TH","year":"1997","journal-title":"AJR Am J Roentgenol"},{"key":"ref29","first-page":"552","article-title":"Pulmonary alveolar microlithiasis: high-resolution computed tomography findings in 10 patients","volume":"33","author":"Marchiori E","year":"2007","journal-title":"J Bras Pneumol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"819242","DOI":"10.1155\/2010\/819242","article-title":"Pulmonary alveolar microlithiasis: a case report with emphasis on imaging findings","volume":"2010","author":"Abdalla G","year":"2010","journal-title":"Case Rep Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.rmed.2012.10.014","article-title":"Pulmonary alveolar microlithiasis. State-of-the-art review","volume":"107","author":"Ferreira Francisco FA","year":"2013","journal-title":"Respir Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/BF01403701","article-title":"Pulmonary alveolar microlithiasis in children","volume":"26","author":"Schmidt H","year":"1996","journal-title":"Pediatr Radiol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1097\/00004728-199803000-00016","article-title":"Pulmonary alveolar microlithiasis: high-resolution CT and MR findings","volume":"22","author":"Hoshino H","year":"1998","journal-title":"J Comput Assist Tomogr"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1097\/00004728-199111000-00006","article-title":"Pulmonary alveolar microlithiasis: CT findings","volume":"15","author":"Cluzel P","year":"1991","journal-title":"J Comput Assist Tomogr"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ejrad.2005.01.010","article-title":"High resolution computed tomographic features of pulmonary alveolar microlithiasis","volume":"55","author":"Deniz O","year":"2005","journal-title":"Eur J Radiol"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1259\/bjr\/96331922","article-title":"Pulmonary alveolar microlithiasis presenting with crazy-paving pattern on high resolution CT","volume":"77","author":"Gasparetto EL","year":"2004","journal-title":"Br J Radiol"},{"key":"ref37","first-page":"317","article-title":"An enlarged heart with hyperdense consolidation","volume":"71","author":"Hochhegger B","year":"2013","journal-title":"Neth J Med"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/01.rti.0000141353.39373.01","article-title":"Unusual manifestations of metastatic pulmonary calcification: high-resolution CT and pathological findings","volume":"20","author":"Marchiori E","year":"2005","journal-title":"J Thorac Imaging"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"e69","DOI":"10.1259\/bjr\/53649455","article-title":"MRI and CT findings of metastatic pulmonary calcification","volume":"85","author":"Hochhegger B","year":"2012","journal-title":"Br J Radiol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1590\/S0100-39842012000500014","article-title":"Pulmonary metastatic calcification: a case report","volume":"45","author":"Bozi LCF","year":"2012","journal-title":"Radiol Bras"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1016\/j.rmed.2014.01.012","article-title":"Metastatic pulmonary calcification: state-of-the-art review focused on imaging findings","volume":"108","author":"Bel\u00e9m LC","year":"2014","journal-title":"Respir Med"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1402","DOI":"10.2214\/AJR.07.2402","article-title":"Silicoproteinosis: highresolution CT findings in 13 patients","volume":"189","author":"Marchiori E","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.ejrad.2010.12.012","article-title":"Comparative study of clinical, pathological and HRCT findings of primary alveolar proteinosis and silicoproteinosis","volume":"81","author":"Souza CA","year":"2012","journal-title":"Eur J Radiol"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1097\/00005382-200401000-00008","article-title":"Inhalational pulmonary talcosis: high-resolution CT findings in 3 patients","volume":"19","author":"Marchiori E","year":"2004","journal-title":"J Thorac Imaging"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00408-010-9230-y","article-title":"Pulmonary talcosis: imaging findings","volume":"188","author":"Marchiori E","year":"2010","journal-title":"Lung"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e136","DOI":"10.1016\/j.crad.2013.10.022","article-title":"Talcosis in soapstone artisans: high-resolution CT findings in 12 patients","volume":"69","author":"Pereira Faria H","year":"2014","journal-title":"Clin Radiol"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.athoracsur.2011.12.006","article-title":"Cystic amyloidosis or lymphoid interstitial pneumonia associated with amyloidosis? A diagnostic challenge","volume":"94","author":"Marchiori E","year":"2012","journal-title":"Ann Thorac Surg"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"6540","DOI":"10.4076\/1757-1626-2-6540","article-title":"Pulmonary amyloidosis with calcified nodules and masses - a six-year computed tomography follow-up: a case report","volume":"2","author":"Vieira IG","year":"2009","journal-title":"Cases J"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1097\/RTI.0b013e3181788d39","article-title":"Consolidation with diffuse or focal high attenuation: computed tomography findings","volume":"23","author":"Marchiori E","year":"2008","journal-title":"J Thorac Imaging"}],"container-title":["Radiologia Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rb\/v48n4\/0100-3984-rb-48-04-0205.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,14]],"date-time":"2023-08-14T06:23:20Z","timestamp":1691994200000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842015000400004&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,8]]},"references-count":49,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2015,8]]}},"alternative-id":["S0100-39842015000400004"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2014.0123","relation":{},"ISSN":["1678-7099"],"issn-type":[{"value":"1678-7099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,8]]}}}