{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T14:34:44Z","timestamp":1792420484691,"version":"4.5.0"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"published-print":{"date-parts":[[2017,10]]},"abstract":"<jats:p>Abstract  Objective: To describe the spectrum of magnetic resonance imaging (MRI) findings in patients with neurological manifestations of dengue.  Materials and Methods: We included nine patients with dengue fever (three females and six males; age range, 9\u201330 years), all of whom presented with neurological manifestations. The MRI examinations, performed in 1.5 T or 3 T scanners, included T1-weighted, T2-weighted, and fluid-attenuated inversion recovery (FLAIR) sequences. Diffusion-weighted imaging with apparent diffusion coefficient mapping was also employed. Fast low-angle shot and susceptibility-weighted gradient-recalled echo sequences, as well as contrast-enhanced T1-weighted scans, were also obtained in order to assess parenchymal enhancement. MRI scans were analyzed for lesion distribution and imaging features.  Results: All patients showed areas of altered signal intensity that appeared as hyperintensity on T2-weighted and FLAIR sequences. The most commonly affected site was the basal ganglia-thalamus complex. Other affected sites were the cerebellum, cerebral cortex, white matter, and brainstem. In all cases, we observed patchy areas of restricted diffusion and focal areas of hemorrhage.  Conclusion: Dengue encephalitis commonly affects the basal ganglia, thalamus, cerebellum, cerebral cortex, and white matter. Therefore, MRI should be an indispensable part of the evaluation of patients with neurological complications of dengue fever.<\/jats:p>","DOI":"10.1590\/0100-3984.2016.0048","type":"journal-article","created":{"date-parts":[[2017,11,1]],"date-time":"2017-11-01T10:06:48Z","timestamp":1509530808000},"page":"285-290","source":"Crossref","is-referenced-by-count":33,"title":["Spectrum of findings on magnetic resonance imaging of the brain in patients with neurological manifestations of dengue fever"],"prefix":"10.1590","volume":"50","author":[{"given":"Tejeshwar Singh","family":"Jugpal","sequence":"first","affiliation":[{"name":"Maulana Azad Medical College,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Dixit","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anju","family":"Garg","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Swati","family":"Gupta","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virendra","family":"Jain","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronak","family":"Patel","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobhit","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Maulana Azad Medical College,  India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1038\/nature12060","article-title":"The global distribution and burden of dengue","volume":"496","author":"Bhatt S","year":"2013","journal-title":"Nature"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"848","DOI":"10.4269\/ajtmh.2001.65.848","article-title":"Prospective case-control study of encephalopathy in children with dengue hemorrhagic fever","volume":"65","author":"Cam BV","year":"2001","journal-title":"Am J Trop Med Hyg"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1111\/j.1442-200X.1992.tb00971.x","article-title":"Dengue encephalopathy","volume":"34","author":"Hendarto SK","year":"1992","journal-title":"Acta Paediatr Jpn"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"228","DOI":"10.4103\/0976-3147.98267","article-title":"Dengue encephalitis in children","volume":"3","author":"Arora SK","year":"2012","journal-title":"J Neurosci Rural Pract"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"906","DOI":"10.1016\/S1474-4422(13)70150-9","article-title":"Neurological complications of dengue virus infection","volume":"12","author":"Carod-Artal FJ","year":"2013","journal-title":"Lancet Neurol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.4103\/0972-2327.91946","article-title":"Neurological complications of dengue fever: experience from a tertiary center of north India","volume":"14","author":"Verma R","year":"2011","journal-title":"Ann Indian Acad Neurol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"719","DOI":"10.1007\/s00330-014-3473-6","article-title":"Dengue encephalitis with predominant cerebellar involvement: report of eight cases with MR and CT imaging features","volume":"25","author":"Hegde V","year":"2015","journal-title":"Eur Radiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.jns.2014.04.018","article-title":"Cranial imaging findings in dengue virus infection","volume":"342","author":"Bhoi SK","year":"2014","journal-title":"J Neurol Sci"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"52","DOI":"10.4103\/0971-3026.150145","article-title":"Acute hemorrhagic encephalitis: an unusual presentation of dengue viral infection","volume":"25","author":"Nadarajah J","year":"2015","journal-title":"Indian J Radiol Imaging"},{"key":"ref10","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/690835","article-title":"Understanding the dengue viruses and progress towards their control","volume":"2013","author":"Rodriguez-Roche R","year":"2013","journal-title":"Biomed Res Int"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1212\/WNL.0b013e3181bd8258","article-title":"Neurologic dengue manifestations associated with intrathecal specific immune response","volume":"73","author":"Puccioni-Sohler M","year":"2009","journal-title":"Neurology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1136\/pgmj.2004.019638","article-title":"Dengue viral infections","volume":"80","author":"Malavige GN","year":"2004","journal-title":"Postgrad Med J"},{"key":"ref13","article-title":"Viral aetiology of central nervous system infections in adults admitted to a tertiary referral hospital in southern Vietnam over 12 years","volume":"8","author":"Tan le V","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref14","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0002533","article-title":"Estimating the burden of Japanese encephalitis virus and other encephalitides in countries of the Mekong region","volume":"8","author":"Tarantola A","year":"2014","journal-title":"PLoS Negl Trop Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S0140-6736(00)02036-5","article-title":"Neurological manifestations of dengue infection","volume":"355","author":"Solomon T","year":"2000","journal-title":"Lancet"},{"key":"ref16","first-page":"647","article-title":"Hippocampal involvement in dengue fever","volume":"46","author":"Yeo PS","year":"2005","journal-title":"Singapore Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"418","DOI":"10.4103\/0028-3886.37103","article-title":"Bilateral thalamic involvement in dengue infection","volume":"55","author":"Kamble R","year":"2007","journal-title":"Neurol India"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.clineuro.2008.03.011","article-title":"Encephalitis and myelitis associated with dengue viral infection. Clinical and neuroimaging features","volume":"110","author":"Wasay M","year":"2008","journal-title":"Clin Neurol Neurosurg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1136\/practneurol-2013-000571","article-title":"Spontaneously resolving cerebellar syndrome as a sequelae of dengue viral infection: a case series from Sri Lanka","volume":"14","author":"Weeratunga PN","year":"2014","journal-title":"Pract Neurol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1097\/00004728-200411000-00005","article-title":"Diffusion-weighted MR imaging in Japanese encephalitis","volume":"28","author":"Prakash M","year":"2004","journal-title":"J Comput Assist Tomogr"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e782","DOI":"10.1259\/bjr\/30039090","article-title":"Clinico-radiological spectrum of bilateral temporal lobe hyperintensity: a retrospective review","volume":"85","author":"Sureka J","year":"2012","journal-title":"Br J Radiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"456","DOI":"10.4103\/0028-3886.158269","article-title":"Bilateral isolated basal ganglia bleed: an atypical presentation of Japanese encephalitis","volume":"63","author":"Mahale R","year":"2015","journal-title":"Neurol India"},{"key":"ref23","first-page":"144","article-title":"Bilateral intracerebral haemorrhages: an atypical presentation of Japanese encephalitis","volume":"53","author":"Sarkar N","year":"2005","journal-title":"J Assoc Physicians India"},{"key":"ref24","first-page":"238","article-title":"Acute disseminated encephalomyelitis","volume":"50","author":"Murthy JM","year":"2002","journal-title":"Neurol India"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1007\/s101560200030","article-title":"Acute disseminated encephalomyelitis following dengue fever","volume":"8","author":"Yamamoto Y","year":"2002","journal-title":"J Infect Chemother"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"595","DOI":"10.4103\/0028-3886.68661","article-title":"Acute disseminating encephalomyelitis with hemorrhage following dengue","volume":"58","author":"Gera C","year":"2010","journal-title":"Neurol India"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1186\/1752-1947-6-43","article-title":"Epstein-Barr virus co-infection in a patient with dengue fever presenting with post-infectious cerebellitis: a case report","volume":"6","author":"Karunarathne S","year":"2012","journal-title":"J Med Case Reports"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"465","DOI":"10.3109\/13550289809114548","article-title":"virus in the brain of a fatal case of hemorrhagic dengue fever","volume":"4","author":"Ramos C","year":"1998","journal-title":"J Neurovirol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1080\/14734220260418457","article-title":"Acute cerebellitis","volume":"1","author":"Sawaishi Y","year":"2002","journal-title":"Cerebellum"}],"container-title":["Radiologia Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rb\/v50n5\/0100-3984-rb-50-05-0285.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2017,11,29]],"date-time":"2017-11-29T17:00:34Z","timestamp":1511974834000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842017000500285&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,10]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2017,10]]}},"alternative-id":["S0100-39842017000500285"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2016.0048","relation":{},"ISSN":["0100-3984"],"issn-type":[{"value":"0100-3984","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,10]]}}}