{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,27]],"date-time":"2025-04-27T13:22:45Z","timestamp":1745760165945},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To evaluate SPECT\/CT with radiolabeled somatostatin analogues (RSAs) in systemic granulomatous infections in comparison with gallium-67 (67Ga) citrate scintigraphy.  Materials and Methods: We studied 28 patients with active systemic granulomatous infections, including tuberculosis, paracoccidioidomycosis, pneumocystosis, cryptococcosis, aspergillosis, leishmaniasis, infectious vasculitis, and an unspecified opportunistic infection. Of the 28 patients, 23 had started specific treatment before the study outset. All patients underwent whole-body SPECT\/CT imaging: 7 after injection of 99mTc-EDDA-HYNIC-TOC, and 21 after injection of 111In-DTPA-octreotide. All patients also underwent 67Ga citrate imaging, except for one patient who died before the 67Ga was available.  Results: In 20 of the 27 patients who underwent imaging with both tracers, 27 sites of active disease were detected by 67Ga citrate imaging and by SPECT\/CT with an RSA. Both tracers had negative results in the other 7 patients. RSA uptake was visually lower than 67Ga uptake in 11 of the 20 patients with positive images and similar to 67Ga uptake in the other 9 patients. The only patient who did not undergo 67Ga scintigraphy underwent 99mTc-EDDA-HYNIC-TOC SPECT\/CT-guided biopsy of a lung cavity with focal RSA uptake, which turned to be positive for aspergillosis.  Conclusion: SPECT\/CT with 99mTc-EDDA-HYNIC-TOC or 111In-DTPA-octreotide seems to be a good alternative to 67Ga citrate imaging for the evaluation of patients with systemic granulomatous disease.<\/jats:p>","DOI":"10.1590\/0100-3984.2016.0076","type":"journal-article","created":{"date-parts":[[2017,10,21]],"date-time":"2017-10-21T22:29:14Z","timestamp":1508624954000},"page":"378-382","source":"Crossref","is-referenced-by-count":7,"title":["SPECT\/CT with radiolabeled somatostatin analogues in the evaluation of systemic granulomatous infections"],"prefix":"10.1590","volume":"50","author":[{"given":"Paulo Henrique Silva","family":"Monteiro","sequence":"first","affiliation":[{"name":"State University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thiago Ferreira de","family":"Souza","sequence":"additional","affiliation":[{"name":"State University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Luiza","family":"Moretti","sequence":"additional","affiliation":[{"name":"State University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariangela Ribeiro","family":"Resende","sequence":"additional","affiliation":[{"name":"State University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jair","family":"Mengatti","sequence":"additional","affiliation":[{"name":"Nuclear Energy and Research Institute,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana da Cunha Lopes de","family":"Lima","sequence":"additional","affiliation":[{"name":"State University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allan Oliveira","family":"Santos","sequence":"additional","affiliation":[{"name":"State University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Celso Dar\u00edo","family":"Ramos","sequence":"additional","affiliation":[{"name":"State University of Campinas,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2017,10,23]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"S105","DOI":"10.1093\/annonc\/12.suppl_2.S105","article-title":"The clinical management of neuroendocrine tumors with long-acting repeatable (LAR) octreotide: comparison with standard subcutaneous octreotide therapy","volume":"12","author":"Dogliotti L","year":"2001","journal-title":"Ann Oncol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/BF00181765","article-title":"Somatostatin receptor scintigraphy with [111In-DTPA-D-Phe1]- and [123I-Tyr3]-octreotide: the Rotterdam experience with more than 1000 patients","volume":"20","author":"Krenning EP","year":"1993","journal-title":"Eur J Nucl 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