{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T08:03:46Z","timestamp":1759565026510,"version":"3.37.3"},"reference-count":13,"publisher":"FapUNIFESP (SciELO)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract Objective: To describe head computed tomography (CT) findings in neonates with congenital Zika virus infection confirmed in cerebrospinal fluid. Materials and Methods: This was a study of 16 newborn infants who exhibited abnormal head CT findings during an outbreak of Zika virus infection. Those infants had the following features: brain imaging suggestive of congenital infection; brain calcifications and negative results on tests for other main infectious causes of primary microcephaly, namely toxoplasmosis, cytomegalovirus, rubella, and HIV; positivity for Zika virus on IgM antibody capture enzyme-linked immunosorbent assay in cerebrospinal fluid. Results: Decreased brain volume was observed in 13 (81.2%) of the infants. All of the infants showed cortico-subcortical calcifications, mainly located in the frontal lobe. In 15 neonates (93.7%), ventriculomegaly was observed. Colpocephaly was a common finding, being observed in 10 patients (62.5%). A prominent occipital bone was identified in 9 patients (56.2%). Conclusion: Our study proves that Zika virus infection can cause congenital brain damage, with or without microcephaly. Some predominant head CT findings in neonates with congenital Zika virus infection, although not pathognomonic, are strongly suggestive of a pattern.<\/jats:p>","DOI":"10.1590\/0100-3984.2017.0119","type":"journal-article","created":{"date-parts":[[2018,11,17]],"date-time":"2018-11-17T19:09:24Z","timestamp":1542481764000},"page":"366-371","source":"Crossref","is-referenced-by-count":10,"title":["Common findings on head computed tomography in neonates with confirmed congenital Zika syndrome"],"prefix":"10.1590","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4418-9429","authenticated-orcid":false,"given":"Natacha Calheiros de Lima","family":"Petribu","sequence":"first","affiliation":[{"name":"Hospital Bar\u00e3o de Lucena, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6221-2127","authenticated-orcid":false,"given":"Andrezza Christine Vieira","family":"Fernandes","sequence":"additional","affiliation":[{"name":"Hospital Bar\u00e3o de Lucena, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2621-7067","authenticated-orcid":false,"given":"Mar\u00edlia de Brito","family":"Abath","sequence":"additional","affiliation":[{"name":"Hospital Bar\u00e3o de Lucena, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5072-8487","authenticated-orcid":false,"given":"Luziany Carvalho","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Hospital Bar\u00e3o de Lucena, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2184-167X","authenticated-orcid":false,"given":"Felipe Reis Silva de","family":"Queiroz","sequence":"additional","affiliation":[{"name":"Hospital Bar\u00e3o de Lucena, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2929-3129","authenticated-orcid":false,"given":"Janni\u00ea de Miranda","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Imago, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2707-6817","authenticated-orcid":false,"given":"Glauber Barbosa de","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Hospital Bar\u00e3o de Lucena, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1641-9386","authenticated-orcid":false,"given":"Vanessa van der","family":"Linden","sequence":"additional","affiliation":[{"name":"Hospital Bar\u00e3o de Lucena, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2018,11,14]]},"reference":[{"series-title":"Epidemiological alert: increase of microcephaly in the northeast of Brazil - 17 November 2015","key":"ref1"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"O595","DOI":"10.1111\/1469-0691.12707","article-title":"Rapid spread of emerging Zika virus in the Pacific area","volume":"20","author":"Musso D","year":"2014","journal-title":"Clin Microbiol Infect"},{"series-title":"Informe epidemiol\u00f3gico n\u00ba 08 - Monitoramento dos casos de microcefalia no Brasil","key":"ref3"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1016\/S1473-3099(16)00095-5","article-title":"Detection and sequencing of Zika virus from amniotic fluid of fetuses with microcephaly in Brazil: a case study","volume":"16","author":"Calvet G","year":"2016","journal-title":"Lancet Infect Dis"},{"series-title":"WHO statement on the first meeting of the International Health Regulations (2005) (IHR 2005) Emergency Committee on Zika virus and observed increase in neurological disorders and neonatal malformations","key":"ref5"},{"series-title":"Epidemiological update: neurological syndrome, congenital anomalies and Zika virus infection. 17 January 2016","key":"ref6"},{"series-title":"Protocolo cl\u00ednico e epidemiol\u00f3gico - microcefalia. Vers\u00e3o n\u00ba 02.","key":"ref7"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1823","DOI":"10.1128\/JCM.38.5.1823-1826.2000","article-title":"Standardization of immunoglobulin M capture enzyme-linked immunosorbent assays for routine diagnosis of arboviral infections","volume":"38","author":"Martin DA","year":"2000","journal-title":"J Clin Microbiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1056\/NEJMc1603617","article-title":"Computed tomographic findings in microcephaly associated with Zika virus","volume":"374","author":"Hazin AN","year":"2016","journal-title":"N Engl J Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"i1901","DOI":"10.1136\/bmj.i1901","article-title":"Clinical features and neuroimaging (CT and MRI) findings in presumed Zika virus related congenital infection and microcephaly: retrospective case series study","volume":"353","author":"Arag\u00e3o MFV","year":"2016","journal-title":"BMJ"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1007\/s00381-016-3074-6","article-title":"Microcephaly and Zika virus: neonatal neuroradiological aspects","volume":"32","author":"Cavalheiro S","year":"2016","journal-title":"Childs Nerv Syst"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1186\/s13578-016-0096-4","article-title":"Studies using IPS cells support a possible link between ZIKA and microcephaly","volume":"6","author":"Guo J","year":"2016","journal-title":"Cell Biosci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1016\/j.cell.2016.04.026","article-title":"Zika research shifts into high gear","volume":"165","year":"2016","journal-title":"Cell"}],"container-title":["Radiologia Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rb\/2018nahead\/0100-3984-rb-20170119.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,15]],"date-time":"2020-11-15T12:12:07Z","timestamp":1605442327000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842018000600006&lng=en&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,11,14]]},"references-count":13,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,12]]}},"alternative-id":["S0100-39842018000600006"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2017.0119","relation":{},"ISSN":["1678-7099","0100-3984"],"issn-type":[{"type":"electronic","value":"1678-7099"},{"type":"print","value":"0100-3984"}],"subject":[],"published":{"date-parts":[[2018,11,14]]}}}