{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,16]],"date-time":"2025-06-16T14:31:45Z","timestamp":1750084305218,"version":"3.37.3"},"reference-count":12,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,6,1]],"date-time":"2019-06-01T00:00:00Z","timestamp":1559347200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To emphasize the most appropriate magnetic resonance imaging (MRI) diffusion protocol for the detection of lesions that cause transient global amnesia, in order to perform an accurate examination, as well as to determine the ideal time point after the onset of symptoms to perform the examination.  Materials and Methods: We evaluated five patients with a diagnosis of transient global amnesia treated between 2012 and 2015. We analyzed demographic characteristics, clinical data, symptom onset, diffusion techniques, and radiological findings. Examination techniques included a standard diffusion sequence (b value = 1000 s\/mm2; slice thickness = 5 mm) and a optimized diffusion sequence (b value = 2000 s\/mm2; slice thickness = 3 mm).  Results: Brain MRI was performed at 24 h or 36 h after symptom onset, except in one patient, in whom it was performed at 12 h after (at which point no changes were seen) and repeated at 36 h after symptom onset (at which point it showed alterations in the right hippocampus). The standard and optimized diffusion sequences were both able to demonstrate focal changes in the hippocampi in all of the patients but one, in whom the changes were demonstrated only in the optimized sequence.  Conclusion: MRI can confirm a clinical hypothesis of transient global amnesia. Knowledge of the optimal diffusion parameters and the ideal timing of diffusion-weighted imaging (&gt; 24 h after symptom onset) are essential to improving diagnostic efficiency.<\/jats:p>","DOI":"10.1590\/0100-3984.2018.0028","type":"journal-article","created":{"date-parts":[[2019,5,8]],"date-time":"2019-05-08T16:02:46Z","timestamp":1557331366000},"page":"161-165","source":"Crossref","is-referenced-by-count":9,"title":["Optimization of magnetic resonance imaging protocol for the diagnosis of transient global amnesia"],"prefix":"10.1590","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7750-6948","authenticated-orcid":false,"given":"Luiz de","family":"Abreu Junior","sequence":"first","affiliation":[{"name":"Grupo Fleury,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5956-5741","authenticated-orcid":false,"given":"Laiz Laura de","family":"Godoy","sequence":"additional","affiliation":[{"name":"Grupo Fleury,  Brazil; Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-592X","authenticated-orcid":false,"given":"Luciana Pinheiro dos Santos","family":"Vaz","sequence":"additional","affiliation":[{"name":"Grupo Fleury,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8789-5262","authenticated-orcid":false,"given":"Andr\u00e9 Evangelista","family":"Torres","sequence":"additional","affiliation":[{"name":"Grupo Fleury,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2049-818X","authenticated-orcid":false,"given":"Angela Maria Borri","family":"Wolosker","sequence":"additional","affiliation":[{"name":"Grupo Fleury,  Brazil; Universidade Federal de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1911-9090","authenticated-orcid":false,"given":"Ulysses Santos","family":"Torres","sequence":"additional","affiliation":[{"name":"Grupo Fleury,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3348-7401","authenticated-orcid":false,"given":"Maria Lucia","family":"Borri","sequence":"additional","affiliation":[{"name":"Grupo Fleury,  Brazil; Universidade Federal de S\u00e3o Paulo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,6]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/j.mayocp.2014.12.001","article-title":"Transient global amnesia","volume":"90","author":"Arena JE","year":"2015","journal-title":"Mayo Clin Proc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1093\/brain\/awl248","article-title":"Selective affection of hippocampal CA-1 neurons in patients with transient global amnesia without long-term sequelae","volume":"129","author":"Bartsch T","year":"2006","journal-title":"Brain"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/S1474-4422(09)70344-8","article-title":"Transient global amnesia: functional anatomy and clinical implications","volume":"9","author":"Bartsch T","year":"2010","journal-title":"Lancet Neurol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neurol.2015.01.003","article-title":"Hippocampal modifications in transient global amnesia","volume":"171","author":"Quinette P","year":"2015","journal-title":"Rev Neurol (Paris)"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1212\/01.WNL.0000130504.88404.C9","article-title":"Detection of delayed focal MR changes in the lateral hippocampus in transient global amnesia","volume":"62","author":"Sedlaczek O","year":"2004","journal-title":"Neurology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.3174\/ajnr.A1105","article-title":"Optimal diffusion-weighted imaging protocol for lesion detection in transient global amnesia","volume":"29","author":"Weon YC","year":"2008","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref7","series-title":"Handbook of clinical neurology","first-page":"2015","volume-title":"Transient global amnesia","author":"Caplan L","year":"1985"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/jnnp.53.10.834","article-title":"Syndromes of transient amnesia: towards a classification. A study of 153 cases","volume":"53","author":"Hodges JR","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1111\/ene.12346","article-title":"Migraine is associated with a higher risk of transient global amnesia: a nationwide cohort study","volume":"21","author":"Lin KH","year":"2014","journal-title":"Eur J Neurol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1640","DOI":"10.1093\/brain\/awl105","article-title":"What does transient global amnesia really mean? Review of the literature and thorough study of 142 cases","volume":"129","author":"Quinette P","year":"2006","journal-title":"Brain"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1136\/jnnp.53.10.834","article-title":"Syndromes of transient amnesia: towards a classification. A study of 153 cases","volume":"53","author":"Hodges JR","year":"1990","journal-title":"J Neurol Neurosurg Psychiatry"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/S0140-6736(98)01442-1","article-title":"Aetiology of transient global amnesia","volume":"352","author":"Lewis SL","year":"1998","journal-title":"Lancet"}],"container-title":["Radiologia Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rb\/v52n3\/0100-3984-rb-20180028.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T14:28:00Z","timestamp":1581085680000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842019000300161&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,6]]},"references-count":12,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2019,6]]}},"alternative-id":["S0100-39842019000300161"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2018.0028","relation":{},"ISSN":["1678-7099"],"issn-type":[{"type":"electronic","value":"1678-7099"}],"subject":[],"published":{"date-parts":[[2019,6]]}}}