{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T02:44:28Z","timestamp":1761965068063,"version":"3.37.3"},"reference-count":23,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,4,1]],"date-time":"2019-04-01T00:00:00Z","timestamp":1554076800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract Objective: To evaluate chest X-ray findings in pediatric patients diagnosed with influenza A (H1N1) virus infection. Materials and Methods: We retrospectively reviewed chest X-ray findings in 17 cases of pulmonary infection with the H1N1 virus (in 7 males and 10 females) examined between 2012 and 2016. The mean age of the patients was 14 months (range, 2-89 months). The diagnosis was established on the basis of clinical and radiographic criteria, and the virus was detected by polymerase chain reaction. The radiographic findings were categorized by type\/pattern of opacity and by lung zone. The patients were divided into two groups: those not requiring ventilatory support; and those requiring ventilatory support or evolving to death. Results: The abnormality most often seen on chest X-rays was that of peribronchovascular opacities, the majority of which affected less than 25% of the lung, the involvement being bilateral and asymmetric. The lung zone most frequently involved was the middle third, with central and peripheral distribution, without pleural effusion. There was a statistically significant difference between the groups in terms of the symmetry of pulmonary involvement, asymmetric findings predominating in the group that required ventilatory support (p = 0.029). Conclusion: In pediatric patients with H1N1 virus infection, the main alterations on the initial chest X-rays are peribronchovascular opacities, nonspecific alveolar opacities, and consolidations. Although the definitive diagnosis of H1N1 virus infection cannot be made on the basis of imaging characteristics alone, using a combination of clinical and radiographic findings can substantially improve the diagnostic accuracy.<\/jats:p>","DOI":"10.1590\/0100-3984.2018.0030","type":"journal-article","created":{"date-parts":[[2019,3,20]],"date-time":"2019-03-20T20:36:52Z","timestamp":1553114212000},"page":"78-84","source":"Crossref","is-referenced-by-count":5,"title":["Initial chest X-ray findings in pediatric patients diagnosed with H1N1 virus infection"],"prefix":"10.1590","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2106-1211","authenticated-orcid":false,"given":"Isa F\u00e9lix","family":"Ad\u00f4rno","sequence":"first","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-1383","authenticated-orcid":false,"given":"Tiago Kojun","family":"Tibana","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8679-7369","authenticated-orcid":false,"given":"R\u00f4mulo Flor\u00eancio Trist\u00e3o","family":"Santos","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0153-777X","authenticated-orcid":false,"given":"Victor Machado Mendes","family":"Le\u00e3o","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7597-1547","authenticated-orcid":false,"given":"Yvone Maia","family":"Brustoloni","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1115-3312","authenticated-orcid":false,"given":"Pedro Augusto Ign\u00e1cio","family":"Silva","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5806-9954","authenticated-orcid":false,"given":"Marco Ant\u00f4nio","family":"Ferreira","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0006-3725","authenticated-orcid":false,"given":"Thiago Franchi","family":"Nunes","sequence":"additional","affiliation":[{"name":"Universidade Federal de Mato Grosso do Sul, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2019,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejrad.2009.11.005","article-title":"High-resolution computed tomography findings from adult patients with influenza A (H1N1) virus-associated pneumonia","volume":"74","author":"Marchiori E","year":"2010","journal-title":"Eur J Radiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"235","DOI":"10.5858\/134.2.235","article-title":"Pulmonary pathologic findings of fatal 2009 pandemic influenza A\/H1N1 viral infections","volume":"134","author":"Gill JR","year":"2010","journal-title":"Arch Pathol Lab Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1590\/S1678-9946201658078","article-title":"A descriptive study of pandemic influenza A (H1N1) pdm09 in Brazil, 2009-2010","volume":"58","author":"Rossetto EV","year":"2016","journal-title":"Rev Inst Med Trop Sao Paulo"},{"key":"ref4","first-page":"4","article-title":"Investiga\u00e7\u00e3o de \u00f3bito relacionado \u00e0 influenza pand\u00eamica H1N1 2009 no munic\u00edpio de Osasco, SP, junho e julho de 2009","volume":"8","author":"Marques D","year":"2011","journal-title":"BEPA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1494","DOI":"10.2214\/AJR.09.3625","article-title":"Swine-origin influenza A (H1N1) viral infection: radiographic and CT findings","volume":"193","author":"Ajlan AM","year":"2009","journal-title":"AJR Am J Roentgenol"},{"series-title":"Interim guidance on specimen collection, processing, and testing for patients with suspected novel influenza A (H1N1) virus infection","key":"ref6"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1148\/radiol.2462070712","article-title":"Fleischner Society: glossary of terms for thoracic imaging","volume":"246","author":"Hansell DM","year":"2008","journal-title":"Radiology"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"ix","DOI":"10.1590\/0100-3984.2017.50.3e3","article-title":"Chest computed tomography in bronchiolitis obliterans after bone marrow transplantation","volume":"50","author":"Hochhegger B","year":"2017","journal-title":"Radiol Bras"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1590\/0100-3984.2016.0093","article-title":"High-resolution computed tomography findings in eight patients with hantavirus pulmonary syndrome","volume":"50","author":"Barbosa DL","year":"2017","journal-title":"Radiol Bras"},{"issue":"4","key":"ref10","first-page":"vii","article-title":"High-resolution computed tomography findings in hantavirus pulmonary syndrome","volume":"50","author":"von Ranke F","year":"2017","journal-title":"Radiol Bras"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1590\/0100-3984.2017.0223","article-title":"Tomographic assessment of thoracic fungal diseases: a pattern and signs approach","volume":"51","author":"Torres PPTS","year":"2018","journal-title":"Radiol Bras"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"vii","DOI":"10.1590\/0100-3984.2018.51.1e2","article-title":"Chest X-ray: an examination that has been in use for centuries but is still essential, especially in the clinical management of newborns in the neonatal intensive care unit","volume":"51","author":"Teixeira SR","year":"2018","journal-title":"Radiol Bras"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1148\/radiol.11092149","article-title":"Imaging of pulmonary viral pneumonia","volume":"260","author":"Franquet T","year":"2011","journal-title":"Radiology"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"934","DOI":"10.1148\/radiol.09092083","article-title":"Swine-origin influenza A (H1N1) viral infection in children: initial chest radiographic findings","volume":"254","author":"Lee EY","year":"2010","journal-title":"Radiology"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.2214\/AJR.09.3599","article-title":"Chest radiographic and CT findings in novel swine-origin influenza A (H1N1) virus (S-OIV) infection","volume":"193","author":"Agarwal PP","year":"2009","journal-title":"AJR Am J Roentgenol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1148\/radiol.2361041278","article-title":"Interpretation of chest radiographs in infants with cough and fever","volume":"236","author":"Bramson RT","year":"2005","journal-title":"Radiology"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S137","DOI":"10.1148\/radiographics.22.suppl_1.g02oc15s137","article-title":"Viral pneumonias in adults: radiologic and pathologic findings","volume":"22","author":"Kim EA","year":"2002","journal-title":"Radiographics"},{"key":"ref18","series-title":"Fraser and Par\u00e9's diagnosis of diseases of the chest","first-page":"3030","volume-title":"The chest wall","author":"Fraser RS","year":"1999","edition":"4th ed"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1259\/0007-1285-32-373-28","article-title":"Lung changes in the recent influenza epidemic","volume":"32","author":"Galloway RW","year":"1959","journal-title":"Br J Radiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1146\/annurev.pathmechdis.3.121806.154316","article-title":"The pathology of influenza virus infections","volume":"3","author":"Taubenberger JK","year":"2008","journal-title":"Annu Rev Pathol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"e500","DOI":"10.1016\/j.ejrad.2010.10.003","article-title":"Influenza A (H1N1) virus-associated pneumonia: high-resolution computed tomography-pathologic correlation","volume":"80","author":"Marchiori E","year":"2011","journal-title":"Eur J Radiol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1378\/chest.110.2.343","article-title":"Interobserver reliability of the chest radiograph in community-acquired pneumonia","volume":"110","author":"Albaum MN","year":"1996","journal-title":"Chest"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1086\/514675","article-title":"High-resolution computed tomography for the diagnosis of community-acquired pneumonia","volume":"27","author":"Syrj\u00e4l\u00e4 H","year":"1998","journal-title":"Clin Infect Dis"}],"container-title":["Radiologia Brasileira"],"original-title":[],"link":[{"URL":"http:\/\/www.scielo.br\/pdf\/rb\/v52n2\/0100-3984-rb-20180030.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,14]],"date-time":"2022-09-14T02:26:39Z","timestamp":1663122399000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842019000200078&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,4]]},"references-count":23,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2019,4]]}},"alternative-id":["S0100-39842019000200078"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2018.0030","relation":{},"ISSN":["1678-7099"],"issn-type":[{"type":"electronic","value":"1678-7099"}],"subject":[],"published":{"date-parts":[[2019,4]]}}}