{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T14:40:56Z","timestamp":1788964856168,"version":"build-2803163510"},"reference-count":34,"publisher":"FapUNIFESP (SciELO)","issue":"4","license":[{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2019,8,1]],"date-time":"2019-08-01T00:00:00Z","timestamp":1564617600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract The elastic properties of tissue have always been of interest in clinical practice. In the past, the identification of structures that were stiffer on physical palpation would raise the suspicion that \u201cthere was something wrong\u201d. With the development and advancement of medicine, there proved to be a true correlation in the prediction of malignancy of a lesion: malignant disease tends to stiffen the affected tissue, either by increased cell proliferation or fibrosis. Palpation is the oldest method for the detection of thyroid nodules, which is informed by the knowledge that malignant thyroid lesions tend to be much harder than benign ones. Unfortunately, palpation is a highly subjective method that is dependent on the size and location of the lesion, as well as on the skill of the physician. In cases where these nodules are very small or are located in deep regions, their detection by palpation is difficult or even impossible. In addition, although a malignant lesion differs in terms of elasticity, it may not have echogenic properties, preventing its detection by conventional ultrasound. Imaging that indicates the stiffness or deformation of tissues, through the use of ultrasound elastography techniques, adds new information related to their structural formation. In this article, we review the basic physical principles of elastography and the evolution of the method for the evaluation of thyroid nodules, as well as the limitations of and future perspectives for its use.<\/jats:p>","DOI":"10.1590\/0100-3984.2018.0084","type":"journal-article","created":{"date-parts":[[2019,8,16]],"date-time":"2019-08-16T17:39:25Z","timestamp":1565977165000},"page":"247-253","source":"Crossref","is-referenced-by-count":29,"title":["Ultrasound elastography in the evaluation of thyroid nodules: evolution of a promising diagnostic tool for predicting the risk of malignancy"],"prefix":"10.1590","volume":"52","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0650-8342","authenticated-orcid":false,"given":"Pedro Henrique de Marqui","family":"Moraes","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5780-4136","authenticated-orcid":false,"given":"Rosa","family":"Sigrist","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9489-2844","authenticated-orcid":false,"given":"Marcelo Straus","family":"Takahashi","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3509-883X","authenticated-orcid":false,"given":"Marcelo","family":"Schelini","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7041-3079","authenticated-orcid":false,"given":"Maria Cristina","family":"Chammas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2019,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"1303","DOI":"10.7150\/thno.18650","article-title":"Ultrasound elastography: review of techniques and clinical applications","volume":"7","author":"Sigrist RMS","year":"2017","journal-title":"Theranostics"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1053\/j.ro.2013.03.009","article-title":"New technologies in clinical ultrasound","volume":"48","author":"Kamaya A","year":"2013","journal-title":"Semin Roentgenol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1177\/016173469101300201","article-title":"Elastography: a quantitative method for imaging the elasticity of biological tissues","volume":"13","author":"Ophir J","year":"1991","journal-title":"Ultrason Imaging"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"433","DOI":"10.2217\/iim.11.41","article-title":"What challenges must be overcome before ultrasound elasticity imaging is ready for the clinic?","volume":"3","author":"Palmeri ML","year":"2011","journal-title":"Imaging Med"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"328","DOI":"10.2174\/157340511798038657","article-title":"Acoustic radiation force impulse (ARFI) imaging: a review","volume":"7","author":"Nightingale K","year":"2012","journal-title":"Curr Med Imaging Rev"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2125","DOI":"10.1002\/hep.25936","article-title":"Accuracy of real-time shear wave elastography for assessing liver fibrosis in chronic hepatitis C: a pilot study","volume":"56","author":"Ferraioli G","year":"2012","journal-title":"Hepatology"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1148\/radiol.11110839","article-title":"Diagnostic performance of gray-scale US and elastography in solid thyroid nodules","volume":"262","author":"Moon HJ","year":"2012","journal-title":"Radiology"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1055\/s-0033-1335375","article-title":"EFSUMB guidelines and recommendations on the clinical use of ultrasound elastography. 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