{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,7]],"date-time":"2025-08-07T21:08:32Z","timestamp":1754600912297,"version":"3.37.3"},"reference-count":41,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To evaluate and reconstruct three-dimensional images of vascularization along the fallopian tube (FT), as well as to determine its relationship with the ovary and ovarian fimbria, and to quantify the blood vessels along the FT according to its anatomical segments, using confocal microtomography (micro-CT).  Materials and Methods: Nine specimens (six FTs and three FTs with ovaries) were fixed in a solution of 10% formalin for &gt; 24 h at room temperature. Iodine staining was performed by soaking the specimens in 10% Lugol\u2019s solution for 24 h. All specimens were evaluated using micro-CT. A morphometric analysis was performed on the reconstructed images to quantify the vascular distribution along the FT.  Results: In the FTs evaluated, the density of blood vessels was significantly greater in the fimbrial segments than in the isthmic segments (p &lt; 0.05). The ovarian fimbria was clearly identified, demonstrating the important relationship between these vessels and the FT fimbriae.  Conclusion: We believe that the vascularization in the fimbriae is greater than and disproportional that in the other segments of FT, and that the ovarian fimbria plays an important role in the development of that difference.<\/jats:p>","DOI":"10.1590\/0100-3984.2019.0080","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T12:32:30Z","timestamp":1588336350000},"page":"161-166","source":"Crossref","is-referenced-by-count":4,"title":["Proportional vascularization along the fallopian tubes and ovarian fimbria: assessment by confocal microtomography"],"prefix":"10.1590","volume":"53","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2350-6587","authenticated-orcid":false,"given":"Pedro Teixeira","family":"Castro","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ),  Brazil; Cl\u00ednica Diagn\u00f3stico por Imagem (CDPI),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1184-2804","authenticated-orcid":false,"given":"Osvaldo Luiz","family":"Aranda","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ),  Brazil; Universidade de Vassouras,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8797-7380","authenticated-orcid":false,"given":"Edson","family":"Marchiori","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3758-2011","authenticated-orcid":false,"given":"Luiz Felipe Bittencourt de","family":"Ara\u00fajo","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense (UFF),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3319-744X","authenticated-orcid":false,"given":"Haimon Diniz Lopes","family":"Alves","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ),  Brazil; Universidade do Estado do Rio de Janeiro (UERJ),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6535-7236","authenticated-orcid":false,"given":"Ricardo Tadeu","family":"Lopes","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro (UFRJ),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8620-7293","authenticated-orcid":false,"given":"Heron","family":"Werner","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Diagn\u00f3stico por Imagem (CDPI),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6145-2532","authenticated-orcid":false,"given":"Edward","family":"Araujo J\u00fanior","sequence":"additional","affiliation":[{"name":"Universidade Federal de S\u00e3o Paulo (EPM-Unifesp),  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"ref1","series-title":"The fallopian tubes: their role in fertility and infertility","first-page":"1","volume-title":"Discovery of the fallopian tubes and subsequent historical landmarks","author":"Hunter RHF","year":"1988"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3322\/caac.21208","article-title":"Cancer statistics, 2014","volume":"64","author":"Siegel R","year":"2014","journal-title":"CA Cancer J Clin"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1097\/01.pas.0000213335.40358.47","article-title":"Intraepithelial carcinoma of the fimbria and pelvic serous carcinoma: evidence for a causal relationship","volume":"31","author":"Kindelberger DW","year":"2007","journal-title":"Am J Surg Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"3921","DOI":"10.1073\/pnas.1117135109","article-title":"High-grade serous ovarian cancer arises from fallopian tube in a mouse model","volume":"109","author":"Kim J","year":"2012","journal-title":"Proc Natl Acad Sci USA"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/his.12046","article-title":"Fallopian tube precursors of ovarian low- and high-grade serous neoplasms","volume":"62","author":"Vang R","year":"2013","journal-title":"Histopathology"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.ijgo.2013.10.001","article-title":"Staging classification for cancer of the ovary, fallopian tube, and peritoneum","volume":"124","author":"Prat J","year":"2014","journal-title":"Int J Gynaecol Obstet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"6116","DOI":"10.1158\/1078-0432.CCR-04-2509","article-title":"Patterns of gene expression in different histotypes of epithelial ovarian cancer correlate with those in normal fallopian tube, endometrium, and colon","volume":"11","author":"Marquez RT","year":"2005","journal-title":"Clin Cancer Res"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"8989","DOI":"10.1038\/ncomms9989","article-title":"The Notch and Wnt pathways regulate stemness and differentiation in human fallopian tube organoids","volume":"6","author":"Kessler M","year":"2015","journal-title":"Nat Commun"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"2487","DOI":"10.1002\/stem.1207","article-title":"Stem-like epithelial cells are concentrated in the distal end of the fallopian tube: a site for injury and serous cancer initiation","volume":"30","author":"Paik DY","year":"2012","journal-title":"Stem Cells"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1038\/nrc.2016.113","article-title":"The disparate origins of ovarian cancers: pathogenesis and prevention strategies","volume":"17","author":"Karnezis AN","year":"2017","journal-title":"Nat Rev Cancer"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/BF00986093","article-title":"Zur funktionellen Morphologie des Fimbrienendes des menschlichen Tube und des Epoophoron","volume":"182","author":"Stange HH","year":"1952","journal-title":"Arch Gynak"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1097\/00000478-200007000-00014","article-title":"Effect of formalin tissue fixation and processing of immunohistochemistry","volume":"24","author":"Werner M","year":"2000","journal-title":"Am J Surg Pathol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"632","DOI":"10.1002\/dvdy.21857","article-title":"MicroCT for developmental biology: a versatile tool for high-contrast 3D imaging at histological resolutions","volume":"238","author":"Metscher BD","year":"2009","journal-title":"Dev Dyn"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"H302","DOI":"10.1152\/ajpheart.00928.2003","article-title":"Quantitative microcomputed tomography analysis of collateral vessel development after ischemic injury","volume":"287","author":"Duvall CL","year":"2004","journal-title":"Am J Physiol Heart Circ Physiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"918","DOI":"10.1016\/j.humpath.2011.03.003","article-title":"Molecular pathogenesis and extraovarian origin of epithelial ovarian cancer-shifting the paradigm","volume":"42","author":"Kurman RJ","year":"2011","journal-title":"Hum Pathol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1097\/PGP.0b013e31826a6446","article-title":"Clinically occult tubal and ovarian high-grade serous carcinomas presenting in uterine samples: diagnostic pitfalls and clues to improve recognition of tumor origin","volume":"32","author":"Bagby C","year":"2013","journal-title":"Int J Gynecol Pathol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2008.e5","DOI":"10.1016\/j.fertnstert.2008.01.071","article-title":"Does the fimbria have an embryologic origin distinct from that of the rest of the fallopian tube?","volume":"90","author":"Garrett LA","year":"2008","journal-title":"Fertil Steril."},{"key":"ref18","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/s10397-012-0773-1","article-title":"Unilateral ovarian absence","volume":"10","author":"Tzitzimikas S","year":"2013","journal-title":"Gynecol Surg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/j.ygyno.2008.05.031","article-title":"The origin of ovarian carcinomas: a developmental view","volume":"110","author":"Auersperg N","year":"2008","journal-title":"Gynecol Oncol"},{"key":"ref20","first-page":"7","article-title":"Temperature gradients in female reproductive tissues and their potential significance","volume":"6","author":"Hunter RHF","year":"2009","journal-title":"Anim Reprod"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1016\/j.rbmo.2011.12.007","article-title":"Temperature gradients in female reproductive tissues","volume":"24","author":"Hunter RHF","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1590\/0100-3984.2016.0208","article-title":"Pitfalls of diffusion-weighted imaging of the female pelvis","volume":"51","author":"Duarte AL","year":"2018","journal-title":"Radiol 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for predicting lumpectomy margin status intraoperatively","volume":"19","author":"Tang R","year":"2013","journal-title":"Breast J"},{"key":"ref30","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20150581","article-title":"Intraoperative micro-computed tomography (micro-CT): a novel method for determination of primary tumour dimensions in breast cancer specimens","volume":"89","author":"Tang R","year":"2016","journal-title":"Br J Radiol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1164\/rccm.201507-1281OC","article-title":"Morphometric analysis of explant lungs in cystic fibrosis","volume":"193","author":"Boon M","year":"2016","journal-title":"Am J Respir Crit Care Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"481","DOI":"10.2215\/CJN.04810515","article-title":"Micro-CT in the assessment of pediatric renal osteodystrophy by bone histomorphometry","volume":"11","author":"Pereira RC","year":"2016","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1111\/clr.12799","article-title":"MicroCT assessment of bone microarchitecture in implant sites reconstructed with autogenous and xenogenous grafts: a pilot study","volume":"28","author":"de Faria Vasconcelos K","year":"2017","journal-title":"Clin Oral Implants Res"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.joen.2016.11.013","article-title":"Micro-computed tomography assessment of dentinal micro-cracks after root canal preparation with TRUShape and Self-Adjusting File systems","volume":"43","author":"Zuolo ML","year":"2017","journal-title":"J Endod"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s40478-016-0321-8","article-title":"Imaging invasion: micro-CT imaging of adamantinomatous craniopharyngioma highlights cell type specific spatial relationships of tissue invasion","volume":"4","author":"Apps JR","year":"2016","journal-title":"Acta Neuropathol Commun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1002\/uog.15764","article-title":"Clinical utility of postmortem microcomputed tomography of the fetal heart: diagnostic imaging vs macroscopic dissection","volume":"47","author":"Hutchinson JC","year":"2016","journal-title":"Ultrasound Obstet Gynecol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"405","DOI":"10.2350\/13-08-1359-OA.1","article-title":"Microtomographic analysis of lower urinary tract obstruction","volume":"16","author":"Siebert JR","year":"2013","journal-title":"Pediatr Dev Pathol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/uog.13330","article-title":"Postmortem microcomputed tomography (micro-CT) of small fetuses and hearts","volume":"44","author":"Lombardi CM","year":"2014","journal-title":"Ultrasound Obstet 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