{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,5]],"date-time":"2025-11-05T21:08:33Z","timestamp":1762376913302,"version":"3.37.3"},"reference-count":29,"publisher":"FapUNIFESP (SciELO)","issue":"2","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To investigate the correlations among the extent of bone involvement, splenic volume, and quality of life in patients with Gaucher disease.  Materials and Methods: This was a descriptive, prospective cross-sectional study of 18 patients with Gaucher disease who underwent 3-T magnetic resonance imaging of both femurs and the lumbar spine. Semiquantitative analyses were performed on the basis of the bone marrow burden (BMB) score. We looked for linear relationships among the variables splenic volume, quality of life score, and BMB score.  Results: We identified a linear relationship between the BMB scores and splenic volume. The quality of life score showed no statistically significant relationship with splenic volume or the BMB score.  Conclusion: The linear relationship between the BMB score and the splenic volume indicates that the extent of bone disease is greater in individuals with splenomegaly. No correlation was found between the BMB and quality of life scores, illustrating the insidious and silent progression of Gaucher disease.<\/jats:p>","DOI":"10.1590\/0100-3984.2020.0014","type":"journal-article","created":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T11:34:33Z","timestamp":1616758473000},"page":"71-76","source":"Crossref","is-referenced-by-count":4,"title":["Skeletal involvement in Gaucher disease: extent of bone disease, splenic volume, and quality of life"],"prefix":"10.1590","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7723-189X","authenticated-orcid":false,"given":"Ricardo Andrade Fernandes de","family":"Mello","sequence":"first","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6284-1097","authenticated-orcid":false,"given":"Melissa Bosi Nonato","family":"Mello","sequence":"additional","affiliation":[{"name":"Centro Capixaba de Oncologia,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8998-3028","authenticated-orcid":false,"given":"La\u00eds Bastos","family":"Pessanha","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7112-7787","authenticated-orcid":false,"given":"Ana Paula Alves","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Universidade Federal do Esp\u00edrito Santo,  Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"530","published-online":{"date-parts":[[2021,4]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"A13","DOI":"10.1259\/bjr.75.suppl_1.750013","article-title":"Imaging and quantifying skeletal involvement in Gaucher disease","volume":"75","author":"Maas M","year":"2002","journal-title":"Br J Radiol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1590\/S1516-84842003000200004","article-title":"Tratamento da doen\u00e7a de Gaucher: um consenso brasileiro","volume":"25","author":"Martins AM","year":"2003","journal-title":"Rev Bras Hematol Hemoter"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1148\/radiol.2292020296","article-title":"Quantification of bone involvement in Gaucher disease: MR imaging bone marrow burden score as an alternative to Dixon quantitative chemical shift MR imaging-initial experience","volume":"229","author":"Maas M","year":"2003","journal-title":"Radiology"},{"key":"ref4","first-page":"318","article-title":"Radiology of Gaucher disease (type 1) and bone manifestations: the Dutch experience","volume":"89","author":"Maas M","year":"2006","journal-title":"J Belg Soc Radiol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1353","DOI":"10.1007\/s00256-014-1891-9","article-title":"Skeletal improvement in patients with Gaucher disease type 1: a phase 2 trial of oral eliglustat","volume":"43","author":"Kamath RS","year":"2014","journal-title":"Skeletal Radiol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"S81","DOI":"10.1016\/S0149-2918(08)00361-5","article-title":"Bone metabolism: implications for Gaucher disease","volume":"30","author":"Mariani G","year":"2008","journal-title":"Clin Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1006\/bcmd.1995.0012","article-title":"The clinical course of treated and untreated Gaucher disease. 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Current issues in diagnosis and treatment","volume":"275","author":"McCabe ERB","year":"1996","journal-title":"JAMA"},{"key":"ref28","first-page":"46","article-title":"Newer aspects of some interesting lipid storage diseases: Tay-Sachs and Gaucher's diseases","volume":"126","author":"Beutler E","year":"1977","journal-title":"West J Med"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1148\/radiology.170.1.2909087","article-title":"Bone and bone marrow changes in Gaucher disease: evaluation with quantitative CT","volume":"170","author":"Rosenthal DI","year":"1989","journal-title":"Radiology"}],"container-title":["Radiologia Brasileira"],"original-title":[],"deposited":{"date-parts":[[2021,3,26]],"date-time":"2021-03-26T11:35:02Z","timestamp":1616758502000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842021000200071&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2021,4]]}},"alternative-id":["S0100-39842021000200071"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2020.0014","relation":{},"ISSN":["1678-7099"],"issn-type":[{"type":"electronic","value":"1678-7099"}],"subject":[],"published":{"date-parts":[[2021,4]]}}}