{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:07:27Z","timestamp":1790698047478,"version":"4.1.0"},"reference-count":17,"publisher":"FapUNIFESP (SciELO)","issue":"3","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To evaluate the effect that external cooling of the salivary glands (ECSG) has on the uptake of gallium-68-labeled prostate-specific membrane antigen (68Ga-PSMA), as an indirect assessment of the capacity of ECSG to reduce the local dose in lutetium-177-PSMA-617 radioligand therapy.  Materials and Methods: Ten patients with prostate cancer were submitted to 68Ga-PSMA positron emission tomography\/computed tomography with unilateral ECSG. The ECSG was started at 30 min before the injection of the radiotracer and maintained until the end of image acquisition (1 h after injection). Each salivary gland was assessed by determining the maximum, mean, and peak standardized uptake values (SUVmax, SUVmean, and SUVpeak, respectively). The volume of each gland was determined in a volume of interest delineated by a threshold SUVmax of 10%. Paired Student\u2019s t-tests were used in order to compare the results.  Results: In terms of the SUV parameters, there were no statistically significant differences between the cooled and contralateral salivary glands. However, the mean volume was 27% lower in the cooled parotid glands than in the contralateral parotid glands (p = 0.004).  Conclusion: The use of ECSG does not appear to reduce 68Ga-PSMA uptake by the salivary glands. In addition, there is yet no evidence that ECSG is effective in preventing salivary gland toxicity.<\/jats:p>","DOI":"10.1590\/0100-3984.2020.0044","type":"journal-article","created":{"date-parts":[[2021,5,24]],"date-time":"2021-05-24T20:17:23Z","timestamp":1621887443000},"page":"171-176","source":"Crossref","is-referenced-by-count":7,"title":["68Ga-PSMA PET\/CT: effect of external cooling on salivary gland uptake"],"prefix":"10.1590","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5478-5283","authenticated-orcid":false,"given":"Matheus Zanelatto","family":"Junqueira","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2373-8230","authenticated-orcid":false,"given":"Nelisa Helena","family":"Rocha","sequence":"additional","affiliation":[{"name":"Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo Octavio Frias de Oliveira,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9766-6332","authenticated-orcid":false,"given":"Marcelo Tatit","family":"Sapienza","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2021,6]]},"reference":[{"issue":"5 Suppl","key":"ref1","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.urology.2009.03.001","article-title":"Understanding the epidemiology, natural history, and key pathways involved in prostate cancer","volume":"73","author":"Crawford ED","year":"2009","journal-title":"Urology"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"djx030","DOI":"10.1093\/jnci\/djx030","article-title":"Annual report to the nation on the status of cancer, 1975-2014, featuring survival","volume":"109","author":"Jemal A","year":"2017","journal-title":"J Natl Cancer 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