{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T12:34:04Z","timestamp":1793795644978,"version":"4.6.1"},"reference-count":15,"publisher":"FapUNIFESP (SciELO)","issue":"1","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"am","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Radiol Bras"],"abstract":"<jats:p>Abstract  Objective: To evaluate acute and chronic changes seen on angiographic and histopathological studies of porcine rete mirabile, comparing those treated with the Menox liquid embolic system (LES) and those treated with the Onyx LES.  Materials and Methods: Five pigs, each weighing approximately 35 kg, were submitted to rete mirabile embolization under general anesthesia and fluoroscopic guidance, with the Menox LES or Onyx LES. Four animals were treated with the Menox LES and underwent cerebral angiography, followed by euthanasia, at 1, 30, 60, and 90 days after embolization. One animal was treated with the Onyx LES underwent the same procedures at 30 days after embolization. In a subsequent histopathological analysis, we compared the Menox LES and Onyx LES in terms of the acute and chronic changes observed.  Results: We observed no significant changes in blood pressure, heart rate, or electrocardiographic parameters that could be attributed to the super-selective infusion of dimethyl sulfoxide or the Menox embolic agent. Fluoroscopy showed adequate material opacity, appropriate progression to the center of the rete mirabile and complete unilateral embolization. Microcatheters were uneventfully detached from the embolized nidus. We observed mild to moderate intravascular and extravascular inflammatory responses, without histological evidence of necrotizing arteritis. There were no adverse neurovascular events.  Conclusion: The Menox LES appears to be safe and effective, as well as being apparently equivalent to the Onyx LES in terms of the postprocedure angiographic and histopathological findings.<\/jats:p>","DOI":"10.1590\/0100-3984.2022.0054","type":"journal-article","created":{"date-parts":[[2023,1,9]],"date-time":"2023-01-09T16:14:32Z","timestamp":1673280872000},"page":"21-26","source":"Crossref","is-referenced-by-count":4,"title":["Acute and chronic changes in porcine rete mirabile after embolization with the Menox system: angiographic and histopathological analyses"],"prefix":"10.1590","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8836-1422","authenticated-orcid":false,"given":"Ricardo Miguel Costa de","family":"Freitas","sequence":"first","affiliation":[{"name":"Universidade de S\u00e3o Paulo (FMUSP),  Brazil; Instituto do C\u00e2ncer do Estado de S\u00e3o Paulo,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4432-144X","authenticated-orcid":false,"given":"Mauricio Ricardo Moreira da","family":"Silva Filho","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (FMUSP),  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0010-8604","authenticated-orcid":false,"given":"Alessandro Rodrigo","family":"Belon","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (FMUSP),  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8036-1225","authenticated-orcid":false,"given":"Brasil Chian Ping","family":"Jeng","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (FMUSP),  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5418-3621","authenticated-orcid":false,"given":"Denilson","family":"Mayrink","sequence":"additional","affiliation":[{"name":"Diagnostika Laboratory,  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1916-7121","authenticated-orcid":false,"given":"Jos\u00e9 Guilherme Mendes Pereira","family":"Caldas","sequence":"additional","affiliation":[{"name":"Universidade de S\u00e3o Paulo (FMUSP),  Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"530","published-online":{"date-parts":[[2023,2]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/S1042-3680(18)30150-5","article-title":"Endovascular management of patients with cerebral arteriovenous malformations","volume":"11","author":"Richling B","year":"2000","journal-title":"Neurosurg Clin N 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Neuroradiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1136\/neurintsurg-2019-014963","article-title":"Initial experience with the new ethylene vinyl alcohol copolymer based liquid embolic agent Menox in the endovascular treatment of cerebral arteriovenous malformations","volume":"11","author":"Sirakov S","year":"2019","journal-title":"J Neurointerv Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1097\/00006123-199811000-00081","article-title":"Nonadhesive liquid embolic agent for cerebral arteriovenous malformations: preliminary histopathological studies in swine rete mirabile","volume":"43","author":"Murayama Y","year":"1998","journal-title":"Neurosurgery"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1177\/1971400920917130","article-title":"Liquid embolic agent Fe3O4-EVOH for endovascular arteriovenous malformation embolisation: preliminary evaluation in an in vivo swine rete mirabile model","volume":"33","author":"Li W","year":"2020","journal-title":"Neuroradiol J"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1177\/1591019918784915","article-title":"In vivo evaluation of the new PHIL low viscosity in a swine rete mirabile model","volume":"24","author":"Samaniego EA","year":"2018","journal-title":"Interv Neuroradiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"889","DOI":"10.3171\/jns.2002.97.4.0889","article-title":"A nonadhesive liquid embolic agent composed of ethylene vinyl alcohol copolymer and ethanol mixture for the treatment of cerebral arteriovenous malformations: experimental study","volume":"97","author":"Hamada JI","year":"2002","journal-title":"J Neurosurg"},{"key":"ref14","first-page":"422","article-title":"Liquid 2-poly-hydroxyethyl-methacrylate embolization of experimental arteriovenous malformations: feasibility study","volume":"23","author":"Klisch J","year":"2002","journal-title":"AJNR Am J Neuroradiol"},{"key":"ref15","first-page":"39","article-title":"Cerebral Aneurysm Multicenter European Onyx (CAMEO) trial: results of a prospective observational study in 20 European centers","volume":"25","author":"Molyneux AJ","year":"2004","journal-title":"AJNR Am J Neuroradiol"}],"container-title":["Radiologia Brasileira"],"original-title":["Altera\u00e7\u00f5es angiogr\u00e1ficas e histopatol\u00f3gicas agudas e cr\u00f4nicas da rete mirabile no modelo su\u00edno com sistema emb\u00f3lico l\u00edquido Menox"],"link":[{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_pdf&pid=S0100-39842023000100008&tlng=en","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,5,2]],"date-time":"2024-05-02T20:22:27Z","timestamp":1714681347000},"score":1,"resource":{"primary":{"URL":"http:\/\/www.scielo.br\/scielo.php?script=sci_arttext&pid=S0100-39842023000100008&tlng=en"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":15,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["S0100-39842023000100008"],"URL":"https:\/\/doi.org\/10.1590\/0100-3984.2022.0054","relation":{},"ISSN":["1678-7099"],"issn-type":[{"value":"1678-7099","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2]]}}}